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antiplasmodial

Comparison of the antiplasmodial and falcipain-2 inhibitory activity of β-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids

March 26, 2010 - 16:07 -- Patrick Sampao
Author(s): 
Renate H. Hans, Jiri Gut, Philip J. Rosenthal, Kelly Chibale
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 7, 1 April 2010, Pages 2234-2237

The synthesis and biological evaluation of two novel series of natural-product-like hybrids based on the chalcone, thiolactone and isatin scaffolds is herein described.

Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: Synthesis, antiplasmodial activity, and cytotoxicity

February 13, 2010 - 09:13 -- Kabogo Ndegwa
Author(s): 
João Lavrado, Alexandra Paulo, Jiri Gut, Philip J. Rosenthal and Rui Moreira
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 18, Issue 4, 15 February 2008, Pages 1378-1381

A series of cryptolepine derivatives has been synthesized through the incorporation of short basic side-chains in the C-11 position of the 10H-indolo[3,2-b]quinoline scaffold.

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Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants

January 31, 2010 - 13:55 -- Ingeborg van Schayk
Author(s): 
H.M Malebo, W Tanja, S.A.M Swaleh, M Cal, M.O Omolo, A Hassanali, U Séquin, M Hamburger, R Brun, I.O Ndiege
Reference: 
Tanzania Journal of Health Research > Vol 11, No 4 (2009)

The antiplasmodial, anti-trypanosomal and anti-leishmanial activity of 25 plant extracts obtained from seven Tanzanian medicinal plants: Annickia (Enantia) kummeriae (Annonaceae), Artemisia annua (Asteraceae), Pseudospondias microcarpa (Anacardiaceae), Drypetes natalensis (Euphorbiaceae), Acridocarpus chloropterus (Malpighiaceae), Maytenus senegalensis (Celastraceae) and Neurautanenia mitis (Papilonaceae), were evaluated in vitro against Plasmodium falciparum K1, Trypanosoma brucei rhodesiense STIB 900 and axenic Leishmania donovani MHOM-ET-67/82.

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Synthesis and evaluation of phenylequine for antimalarial activity in vitro and in vivo

January 28, 2010 - 10:14 -- Kabogo Ndegwa
Author(s): 
Margaret A.L. Blackie, Vanessa Yardley and Kelly Chibale
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 3, 1 February 2010, Pages 1078-1080

Synthesis of the potent antiplasmodial 4-aminoquinoline, phenylequine (PQ), is reported for the first time.

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Analgesic and antimalarial activities of crude leaf extract and fractions of Acalypha wilkensiana

January 21, 2010 - 07:46 -- Kabogo Ndegwa
Author(s): 
John A. Udobanga, Paul A. Nwafora and Jude E. Okokon
Reference: 
Journal of Ethnopharmacology Volume 127, Issue 2, 3 February 2010, Pages 373-378

Antiplasmodial and analgesic activities of leaf extract and fractions of Acalypha wilkensiana were evaluated to ascertain the folkloric claim of its antimalarial and analgesic activities.

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Original quinazoline derivatives displaying antiplasmodial properties

January 14, 2010 - 18:13 -- Kabogo Ndegwa
Author(s): 
Youssef Kabria, Nadine Azasb, Aurélien Dumètreb, Sébastien Hutterb, Michèle Lagetb, Pierre Verhaeghea, Armand Gellisa and Patrice Vanellea
Reference: 
European Journal of Medicinal Chemistry Volume 45, Issue 2, February 2010, Pages 616-622

The multistep synthesis of new quinazoline-derived molecules and their in vitro antiplasmodial evaluation on the W2 chloroquino-resistant Plasmodium falciparum strain is described herein. These molecules have also been studied concerning their in vitro cytotoxicity toward two human cell lines (K652 and HepG2) in order to calculate their respective selectivity indexes (S.I.).

Antiplasmodial activity and toxicity of crude extracts from alternatives parts of plants widely used for the treatment of malaria in Burkina Faso: contribution for their preservation

January 10, 2010 - 15:06 -- Ingeborg van Schayk
Author(s): 
Adama Gansané, Souleymane Sanon, Lamoussa P. Ouattara, Abdoulaye Traoré, Sébastien Hutter, Evelyne Ollivier, Nadine Azas, Alfred S. Traore, Innocent P. Guissou, Sodiomon B. Sirima & Issa Nebié
Reference: 
Parasitology Research, Volume 106, Number 2 / January, 2010 : 335-340

In order to prevent the destruction of the ecology and to sustain the flora mainly for medicinal plants, we investigated on alternative parts taken from four plants already known to display antiplasmodial activities and largely used by traditional healers in sub-Saharan Africa.

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A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity

November 26, 2009 - 06:41 -- Patrick Sampao
Author(s): 
Stefano Guglielmo, Massimo Bertinaria, Barbara Rolando, Marco Crosetti, Roberta Fruttero, Vanessa Yardley, Simon L. Croft, Alberto Gasco
Reference: 
European Journal of Medicinal Chemistry, Volume 44, Issue 12, December 2009, Pages 5071-5079, doi:10.1016/j.ejmech.2009.09.012

The synthesis and the study of new amodiaquine derivatives bearing modified lateral basic chains as new agents with both antimalarial and antileishmanial activities are reported.

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