The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10109 malaria professionals are enjoying the free benefits of MalariaWorld today

antiplasmodial

Not Open Access | Antiplasmodial anthraquinones and hemisynthetic derivatives from the leaves of Tectona grandis (Verbenaceae)

February 23, 2014 - 11:14 -- NOT Open Access
Author(s): 
Theodora K. Kopa, Alembert T. Tchinda, Michel F. Tala, Denis Zofou, Ransom Jumbam, Hippolyte K. Wabo, Vincent P.K. Titanji, Michel Frédérich, Ning-Hua Tan, Pierre Tane
Reference: 
Phytochemistry Letters, Volume 8, May 2014, Pages 41-45

The ethyl acetate-soluble portion, some of the isolated compounds and hemisynthetic derivatives were evaluated for their antiplasmodial activity against the multidrug-resistant Dd2 strain of Plasmodium falciparum

Antiplasmodial activity of novel keto-enamine chalcone-chloroquine based hybrid pharmacophores

April 19, 2012 - 07:57 -- Kabogo Ndegwa
Author(s): 
Koneni V. Sashidhara, Manoj Kumar, Ram K. Modukuri, Rajeev Kumar Srivastava, Awakash Soni, Kumkum Srivastava, Shiv Vardan Singh, J.K. Saxena, Harsh M. Gauniyal, Sunil K. Puri
Reference: 
Bioorganic & Medicinal Chemistry, Volume 20, Issue 9, 1 May 2012, Pages 2971–2981

MalariaWorldA series of novel keto-enamine chalcone-chloroquine based hybrids were synthesized following new methodology developed in our laboratory.

Medical Treatment: 

Global challenges of changing epidemiological patterns of malaria

March 6, 2012 - 07:26 -- Kabogo Ndegwa
Author(s): 
Walther H. Wernsdorfer
Reference: 
Acta Tropica, Volume 121, Issue 3, March 2012, Pages 158–165

MalariaWorldIn the absence of secular climatic changes, the global challenges of changing epidemiological patterns of malaria have to be induced by man, i.e. by a disturbance of the equilibrium between man, vector and the parasite in an environment conducive to the natural transmission of the pathogen.

Medical Condition: 

Synthesis of 2-(aminomethyl)aziridines and their microwave-assisted ring opening to 1,2,3-triaminopropanes as novel antimalarial pharmacophores

January 25, 2011 - 08:31 -- Kabogo Ndegwa
Author(s): 
Matthias, D’hooghe | Sara, Kenis | Karel, Vervisch | Carmen, Lategan | Peter J., Smith | Kelly, Chibale | Norbert, De Kimpe
Reference: 
European Journal of Medicinal Chemistry, Volume 46, Issue 2, February 2011, Pages 579-587

A variety of 2-(aminomethyl)aziridines was prepared and converted into the corresponding 1,2,3-triaminopropanes through a novel, microwave-assisted and regioselective ring opening by diethylamine in acetonitrile.

Medical Condition: 
Medical Treatment: 

Dialkylaminoalkyl derivatives of bicyclic compounds with antiplasmodial activity

September 6, 2010 - 09:14 -- Patrick Sampao
Author(s): 
Johanna Faist, Werner Seebacher, Marcel Kaiser, Reto Brun, Robert Saf, Robert Weis
Reference: 
Bioorganic & Medicinal Chemistry, Volume 18, Issue 18, 15 September 2010, Pages 6796-6804

Dialkylaminoalkyl derivatives of 2-azabicyclo[3.2.2]nonanes and of bicyclo[2.2.2]octanes were prepared and their activities determined in vitro against the multiresistant K1 strain of Plasmodium falciparum.

Medical Condition: 

Short Communication: Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain

May 17, 2010 - 09:38 -- Kabogo Ndegwa
Author(s): 
Roberta Ettari, Maria Zappalà, Nicola Micale, Tanja Schirmeister, Christoph Gelhaus, Matthias Leippe, Astrid Evers, Silvana Grasso
Reference: 
European Journal of Medicinal Chemistry, Volume 45, Issue 7, July 2010, Pages 3228-3233

This paper describes the synthesis of novel peptidomimetics bearing a protected aspartyl aldeyde warhead leading to the thioacylals 2a,b and the acylals 3a,b.

Medical Condition: 
Medical Treatment: 

Design and preparation of aza-analogues of benzo[c]phenanthridine framework with cytotoxic and antiplasmodial activities

May 17, 2010 - 09:34 -- Kabogo Ndegwa
Author(s): 
Ange-Désiré Yapi, Nicolas Desbois, Jean-Michel Chezal, Olivier Chavignon, Jean-Claude Teulade, Alexis Valentin, Yves Blache
Reference: 
European Journal of Medicinal Chemistry, Volume 45, Issue 7, July 2010, Pages 2854-2859

Benzo[c]phenanthridine alkaloids represent interesting lead for the discovery of new potential antiplasmodial and/or anticancer drugs. In this field, a novel library of aza-analogs of benzo[c]phenanthroline framework derivatives was designed and prepared.

Medical Condition: 
Medical Treatment: 

Open Access | Antiplasmodial activity of Ajuga bracteosa against Plasmodium berghei infected BALB/c mice

April 29, 2010 - 13:48 -- Kabogo Ndegwa
Author(s): 
Chandel S, Bagai U
Reference: 
Indian J Med Res. 2010 Mar;131:440-4

ELEAB inhibited parasitaemia and enhanced mean survival time in a dose- dependent manner upto 750 mg/kg/day dose in treated mice. Further studies need to be done to isolate and characterize active constituents of extract and to study their mechanism of action.

Technology: 

Antiplasmodial, Antitrypanosomal, and Cytotoxic Activities of Prenylated Flavonoids Isolated from the Stem Bark of Artocarpus styracifolius

April 13, 2010 - 14:24 -- Kabogo Ndegwa
Author(s): 
M Bourjot, C Apel, MT Martin, P Grellier, VH Nguyen, F Guéritte, M Litaudon
Reference: 
Planta Med 2010

In continuation of our efforts to find new antimalarial drugs, a systematic in vitro evaluation using a chloroquine resistant strain of Plasmodium falciparum (FcB1) was undertaken on extracts prepared from various parts of Vietnamese plants. 

Medical Treatment: 

Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha

March 31, 2010 - 12:26 -- Patrick Sampao
Author(s): 
Phurpa Wangchuk, John B. Bremner, Samten, Roonglawan Rattanajak, Sumalee Kamchonwongpaisan
Reference: 
Phytotherapy Research, Volume 24, Issue 4, Date: April 2010, Pages: 481-485

The results thus support, at a molecular level, the clinical use of this plant in the Bhutanese traditional medicine and identified cheilanthifoline as a potential new antimalarial drug lead.

Country: 
Medical Condition: 

Pages

Subscribe to RSS - antiplasmodial