The loss of chloroquine due to selection and spread of drug resistant Plasmodium falciparum parasites has greatly impacted malaria control, especially in highly endemic areas of Africa.
Malaria Journal 2010, 9:374 (23 December 2010)
Antimicrobial Agents and Chemotherapy, September 2010, p. 3714-3716, Vol. 54, No. 9
Mutations in the Plasmodium falciparum genes pfcrt and pfmdr1 are selected by amodiaquine treatment in Africa.