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amodiaquine resistance

Open Access | Commentary: Protecting the malaria drug arsenal: halting the rise and spread of amodiaquine resistance by monitoring the PfCRT SVMNT type

December 29, 2010 - 11:48 -- Kabogo Ndegwa
Author(s): 
Sa JM, Twu O
Reference: 
Malaria Journal 2010, 9:374 (23 December 2010)

The loss of chloroquine due to selection and spread of drug resistant Plasmodium falciparum parasites has greatly impacted malaria control, especially in highly endemic areas of Africa.

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Amodiaquine Resistance in Plasmodium falciparum Malaria in Afghanistan Is Associated with the pfcrt SVMNT Allele at Codons 72 to 76

August 18, 2010 - 12:48 -- Kabogo Ndegwa
Author(s): 
Khalid Beshir, Colin J. Sutherland, Ioannis Merinopoulos, Naeem Durrani, Toby Leslie, Mark Rowland, and Rachel L. Hallett
Reference: 
Antimicrobial Agents and Chemotherapy, September 2010, p. 3714-3716, Vol. 54, No. 9

Mutations in the Plasmodium falciparum genes pfcrt and pfmdr1 are selected by amodiaquine treatment in Africa.

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