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parasitaemia

Open Access | Population Genetic Analysis of Plasmodium falciparum Parasites Using a Customized Illumina GoldenGate Genotyping Assay

June 9, 2011 - 07:45 -- Kabogo Ndegwa
Author(s): 
Susana Campino, Sarah Auburn, Dominic P. Kwiatkowski, et al.
Reference: 
PLoS ONE 6(6): e20251

The diversity in the Plasmodium falciparum genome can be used to explore parasite population dynamics, with practical applications to malaria control.

Severe malaria--clinical case

May 23, 2011 - 14:14 -- Patrick Sampao
Author(s): 
Pires A, Capela C, Gouveia P, Mariz J, Gomes G, Oliveira J.
Reference: 
Rev Port Pneumol. 2011 Jan;17(1):41-3.

We report a clinical case of severe malaria, where the rate of initial parasitaemia by Plasmodium falciparum was 43 %. Multiple organ dysfunction, including ARDS, forced admission in a close surveillance unit, with survival of the same.

Parasitology: Validation of PCR for detection and characterization of parasitaemia in massive splenomegaly attributed clinically to malaria infection

May 17, 2011 - 15:19 -- Patrick Sampao
Author(s): 
Salwa M.E. A-Elgayoum, El-Amin El-Rayah, Hayder A. Giha
Reference: 
Diagnostic Microbiology and Infectious Disease, Volume 70, Issue 2, June 2011, Pages 207-212

In this study, 101 patients with massive splenomegaly (MS) and 41 with moderate splenomegaly (MoS) from Kassala, Eastern Sudan, were included.

Open Access | Antibody levels to multiple malaria vaccine candidate antigens in relation to clinical malaria episodes in children in the Kasena-Nankana district of Northern Ghana

May 5, 2011 - 07:16 -- Kabogo Ndegwa
Author(s): 
Daniel Dodoo, Frank Atuguba, Samuel Bosomprah, Nana Akosua Ansah, Patrick Ansah, Helena Lamptey, Beverly Egyir, Abraham R Oduro, Ben Gyan, Abraham Hodgson, Kwadwo A Koram
Reference: 
Malaria Journal 2011, 10:108 (1 May 2011)

The data from this study support the view that a multivalent vaccine involving different antigens is most likely to be more effective than a monovalent one.

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Open Access | Parasitostatic effect of maslinic acid. II. Survival increase and immune protection in lethal Plasmodium yoelii-infected mice

April 28, 2011 - 06:53 -- Kabogo Ndegwa
Author(s): 
Carlos Moneriz, Patricia Marin-Garcia, Jose M Bautista, Amalia Diez, Antonio Puyet
Reference: 
Malaria Journal 2011, 10:103 (25 April 2011)

The survival increase observed in MA-treated mice can be explained considering that the parasitostatic effect exerted by this compound during the first days of infection increases the chances to develop effective innate and/or acquired immune responses.

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Open Access | ABO blood group and the risk of placental malaria in sub-Saharan Africa

April 27, 2011 - 12:02 -- Kabogo Ndegwa
Author(s): 
Ayola A Adegnika, Adrian JF Luty, Martin P Grobusch, Michael Ramharter, Maria Yazdanbakhsh, Peter G Kremsner, Norbert G Schwarz
Reference: 
Malaria Journal 2011, 10:101 (22 April 2011)

Studies conducted in The Gambia and Malawi suggest that blood group O confers a higher risk of active placental infection in primiparae, but a significantly lower risk in multiparae.

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Open Access | Comparison of the in vitro invasive capabilities of Plasmodium falciparum schizonts isolated by Percoll gradient or using magnetic based separation

April 23, 2011 - 08:14 -- Kabogo Ndegwa
Author(s): 
Carmenza Spadafora, Lucia Gerena, Karen M Kopydlowski
Reference: 
Malaria Journal 2011, 10:96 (18 April 2011)

In this comparison, magnetic bead column separation of 7G8 schizonts resulted in higher viability and efficiency of invasion than utilizing Percoll gradient centrifugation.

Open Access | Activation of the hypnozoite: a part of Plasmodium vivax life cycle and survival

April 23, 2011 - 07:33 -- Kabogo Ndegwa
Author(s): 
Lena Hulden, Larry Hulden
Reference: 
Malaria Journal 2011, 10:90 (16 April 2011)

Artificial triggering of hypnozoites would make the medication more effective and resistance against a protein that the parasite itself uses during its life cycle would not develop.

Open Access | A real-time, quantitative PCR method using hydrolysis probes for the monitoring of Plasmodium falciparum load in experimentally infected human volunteers

March 2, 2011 - 09:25 -- Kabogo Ndegwa
Author(s): 
Rockett RJ, Tozer SJ, Peatey C, Bialasiewicz S, Whiley DM, Nissen MD, Trenholme K, Mc Carthy JS, Sloots TP
Reference: 
Malaria Journal 2011, 10:48 (28 February 2011)

These results show that the hydrolysis probe rt-qPCR assay is superior to the SYBR Green rt-qPCR for the quantification of P. falciparum in human blood samples.

Open Access | Two Strategies for the Delivery of IPTc in an Area of Seasonal Malaria Transmission in The Gambia: A Randomised Controlled Trial

March 1, 2011 - 07:36 -- Kabogo Ndegwa
Author(s): 
Kalifa A. Bojang, Francis Akor, Lesong Conteh, Emily Webb, Ousman Bittaye, David J. Conway, Momodou Jasseh, Virginia Wiseman, Paul J. Milligan, Brian Greenwood
Reference: 
PLoS Med 8(2): e1000409

In this setting in The Gambia, delivery of IPTc to children 6 years of age and under by VHWs is more effective and less costly than delivery through RCH trekking clinics.

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