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HIV

Open Access | Protective efficacy of co-trimoxazole prophylaxis against malaria in HIV exposed children in rural Uganda: a randomised clinical trial

May 5, 2011 - 07:07 -- Kabogo Ndegwa
Author(s): 
Taylor G Sandison, Jaco Homsy, Jordan W Tappero, et al.
Reference: 
BMJ 2011; 342:d1617 (Published 31 March 2011

Co-trimoxazole prophylaxis was moderately protective against malaria in HIV exposed infants when continued beyond the period of HIV exposure despite the high prevalence of Plasmodium genotypes associated with antifolate resistance.

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Open Access | Effect of HIV infection on the acute antibody response to malaria antigens in children: an observational study

March 9, 2011 - 08:17 -- Kabogo Ndegwa
Author(s): 
Muema DK, Ndungu FM, Kinyanjui SM, Berkley JA
Reference: 
Malaria Journal 2011, 10:55 (5 March 2011)

In children with severe malaria, HIV infection is associated with a lower magnitude and narrower breadth of IgG responses to merozoite antigens and stunting of age-related acquisition of the IgG antibody response to schizont extract.

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Open Access | Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance

June 24, 2010 - 09:52 -- Kabogo Ndegwa
Author(s): 
Gasasira AF, Kamya MR, Ochong EO, Vora N, Achan J, Charlebois E, Ruel T, Kateera F, Meya DN, Havlir D, Rosenthal PJ, Dorsey G
Reference: 
Malaria Journal 2010, 9:177 (23 June 2010)

Despite high prevalence of known anti-folate resistance-mediating mutations, TS prophylaxis was highly effective against malaria, but was associated with presence of dhfr 164L mutation.

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Open Access | Using an Improved Phagocytosis Assay to Evaluate the Effect of HIV on Specific Antibodies to Pregnancy-Associated Malaria

May 28, 2010 - 10:09 -- Kabogo Ndegwa
Author(s): 
Ricardo Ataíde, Wina Hasang, Danny W. Wilson, James G. Beeson, Victor Mwapasa, Malcolm E. Molyneux, Steven R. Meshnick, Stephen J. Rogerson
Reference: 
PLoS ONE 5(5): e10807.

This flow cytometry-based phagocytosis assay proved to be efficient and accurate for the measurement of Fc-receptor mediated phagocytosis-inducing antibodies in large cohorts. HIV was found to affect mainly the acquisition of antibodies to pregnancy-specific malaria in primigravidae. Further studies of the relationship between opsonising antibodies to malaria in pregnancy and HIV are indicated.

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Plasmodium falciparum Dihydrofolate Reductase and Dihyropteroate Synthase Mutations and the Use of Trimethoprim-Sulfamethoxazole Prophylaxis among Persons Infected with Human Immunodeficiency Virus

May 4, 2010 - 14:19 -- Patrick Sampao
Author(s): 
Samuel Malamba, Taylor Sandison, John Lule, Arthur Reingold, Jordan Walker, Grant Dorsey, AND Jonathan Mermin
Reference: 
Am J Trop Med Hyg, May 2010; 82: 766 - 771.

Although resistance rates of P. falciparum to antifolate drugs are high, cotrimoxazole-prophylaxis in HIV-infected persons was not associated with a higher prevalence of mutations associated with antifolate resistance. 

Malaria Parasitemia and CD4 T Cell Count, Viral Load, and Adverse HIV Outcomes Among HIV-Infected Pregnant Women in Tanzania

April 13, 2010 - 07:40 -- Patrick Sampao
Author(s): 
Molly F. Franke, Donna Spiegelman, Amara Ezeamama, Said Aboud, Gernard I. Msamanga, Saurabh Mehta, AND Wafaie W. Fawzi
Reference: 
American Journal of Tropical Medicine Hygien, Vol 82 : 4, 2010, pp. 556-562

Parasitemia level was nonlinearly associated with viral load at baseline and among measurements taken > 90 days post-baseline; women with low baseline parasitemia, versus none, had higher viral loads at both time points.

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Pharmacokinetic interactions between ritonavir and quinine in healthy volunteers following concurrent administration

February 11, 2010 - 13:39 -- Kabogo Ndegwa
Author(s): 
Julius O. Soyinka, Cyprian O. Onyeji, Sharon I. Omoruyi, Adegbenga R. Owolabi, Pullela V. Sarma, James M. Cook
Reference: 
British Journal of Clinical Pharmacology, Volume 69, Issue 3, March 2010, Pages: 262-270

Downward dosage adjustment of quinine appears necessary when concurrently administered with ritonavir.

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Open Access | Conflict-affected displaced persons need to benefit more from HIV and malaria national strategic plans and Global Fund grants

February 1, 2010 - 11:24 -- Ingeborg van Schayk
Tags: 
Author(s): 
Spiegel PB, Hering H, Paik E, Schilperoord M
Reference: 
Conflict and Health 2010, 4:2 (29 January 2010)

Access to HIV and malaria control programmes for refugees and internally displaced persons (IDPs) is not only a human rights issue but a public health priority for affected populations and host populations.

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Brief report: HIV Protease Inhibitors, Indinavir or Nelfinavir, Augment Antimalarial Action of Artemisinin in vitro

January 14, 2010 - 11:06 -- Ingeborg van Schayk
Author(s): 
Lokesh C. Mishra, Amit Bhattacharya, Manish Sharma, AND Virendra K. Bhasin
Reference: 
Am J Trop Med Hyg 2010;82 148-150

Most malaria endemic regions are co-infested with HIV infection. 

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Brief report: Utility of a Point-of-Care Malaria Rapid Diagnostic Test for Excluding Malaria as the Cause of Fever among HIV-Positive Adults in Rural Rakai, Uganda

January 14, 2010 - 11:01 -- Ingeborg van Schayk
Author(s): 
Lisa A. Mills, Joseph Kagaayi, Gertrude Nakigozi, Ronald M. Galiwango, Joseph Ouma, Joseph P. Shott, Victor Ssempijja, Ronald H. Gray, Maria J. Wawer, David Serwadda, Thomas C. Quinn, AND Steven J. Reynolds
Reference: 
Am J Trop Med Hyg 2010;82 145-147

We compared results of a malaria rapid diagnostic test (Binax Now® Malaria, Binax-M, Inverness Medical Innovations, Inc., Waltham, MA) performed at rural mobile clinics in Uganda by clinicians evaluating febrile adult HIV patients to thick smear evaluated at a central laboratory by trained microscopists.

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