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placental

Iron Homeostasis in Mother and Child during Placental Malaria Infection

January 7, 2011 - 11:47 -- Patrick Sampao
Author(s): 
Susanne Van Santen, Quirijn de Mast, Adrian J. F. Luty, Erwin T. Wiegerinck, Andre J. A. M. Van der Ven, AND Dorine W. Swinkels
Reference: 
Am J Trop Med Hyg, Jan 2011; 84: 148 - 151.

We conclude that maternal hepcidin is not significantly altered as a function of placental infection and/or anemia. Importantly, fetal hemoglobin and iron status were also unaffected, regardless of the presence of placental infection or maternal anemia.

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Placental Histopathologic Changes Associated with Subclinical Malaria Infection and Its Impact on the Fetal Environment

November 1, 2010 - 13:41 -- Patrick Sampao
Author(s): 
Falgunee K. Parekh, Billie B. Davison, Dionicia Gamboa, Jean Hernandez, and OraLee H. Branch
Reference: 
Am J Trop Med Hyg, Nov 2010; 83: 973 - 980.

This study demonstrated that subclinical malarial infection occurred frequently in pregnant women and is associated with increased presence of monocytes in the placenta.

A Novel Histological Grading Scheme for Placental Malaria Applied in Areas of High and Low Malaria Transmission

October 15, 2010 - 13:58 -- Patrick Sampao
Author(s): 
Atis Muehlenbachs,Michal Fried,Rose McGready,Whitney E. Harrington,Theonest K. Mutabingwa,François Nosten and Patrick E. Duffy
Reference: 
The Journal of Infectious Diseases 2010;202:000–000

Using frozen‐section histologic evaluation in Tanzania (high‐transmission area), we established a novel grading scheme to separately quantify inflammation and pigment deposition during placental malaria (n=102 ).

Review | Of mice and women: rodent models of placental malaria

July 22, 2010 - 09:16 -- Patrick Sampao
Author(s): 
Lars Hviid, Claudio R.F. Marinho, Trine Staalsoe, Carlos Penha-Gonçalves
Reference: 
Trends in Parasitology, Volume 26, Issue 8, August 2010, Pages 412-419

Placental IE sequestration in the intervillous space is mediated by variant surface antigens (VSAs) selectively expressed in placental malaria (PM) and specific for chondroitin sulfate A (CSA). In Plasmodium falciparum, these VSAPM appear largely synonymous with the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family variant VAR2CSA.

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Functional and immunological characterization of the var2CSA-DBL5var epsilon domain of a placental Plasmodium falciparum isolate

July 19, 2010 - 09:23 -- Patrick Sampao
Author(s): 
Stéphane ., Nicaise N., et al.
Reference: 
Molecular and Biochemical Parasitology, Volume 173, Issue 2, October 2010, Pages 115-122

We have expressed the var2CSA-DBL5var epsilon domain, derived from a placental isolate from Senegal, as soluble product in Escherichia coli and have shown using different criteria that the recombinant protein is obtained with the native conformation.

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