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Open Access | Dispatch: Wild Chimpanzees Infected with 5 Plasmodium Species

November 30, 2010 - 10:12 -- Patrick Sampao
Author(s): 
Marco Kaiser, Anna Löwa., Fabian H. Leendertz., et al
Reference: 
Emerging Infectious Diseases ,Volume 16, Number 12–December 2010

We surveyed Plasmodium spp. diversity in wild chimpanzees living in an undisturbed tropical rainforest habitat and found 5 species: P. malariae, P. vivax, P. ovale, P. reichenowi, and P. gaboni.

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Open Access | Oral Presentation: Wild chimpanzees are infected with homologous types of human malaria

November 8, 2010 - 15:02 -- Patrick Sampao
Author(s): 
Marco Kaiser, Dorothy H Bray, Zinta Zommers, Emmanuel Couacy-Hymann, Thomas R Gillespie, Heinz Ellerbrok, Fabian H Leendertz
Reference: 
Malaria Journal 2010, 9(Suppl 2):O21 (20 October 2010)

Recent studies using molecular approaches demonstrated that wild and captive gorillas and captive bonobos and chimpanzees are infected with P. falciparum and that these apes harbor parasites broadly related to P. falciparum.

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Open Access | Oral Presentation: A micro-bead device to explore Plasmodium falciparum-infected, spherocytic or aged red blood cells prone to mechanical retention by spleen endothelial slits

November 5, 2010 - 12:55 -- Patrick Sampao
Author(s): 
Guillaume Deplaine, Innocent Safeukui,Pierre A Buffet et al.
Reference: 
Malaria Journal 2010, 9(Suppl 2):O10 (20 October 2010)

We designed a micro-bead device mimicking the geometry of the human narrow and short inter-endothelial slits. Upon filtration through a mixture of 5-25 μm diameter micro-beads, Plasmodium falciparum-hosting RBC (Pf-RBC) were retained in a parasite developmental stage-dependent way, the retention rates of a subset of ring-RBC being similar in micro-beads and in isolated-perfused human spleens.

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Open Access | Rapid and Highly Sensitive Detection of Malaria-Infected Erythrocytes Using a Cell Microarray Chip

October 17, 2010 - 14:55 -- Patrick Sampao
Author(s): 
Shouki Yatsushiro, Shohei Yamamura, Yuka Yamaguchi, Yasuo Shinohara, Eiichi Tamiya, Toshihiro Horii, Yoshinobu Baba, Masatoshi Kataoka
Reference: 
PLoS ONE 5(10): e13179.

To examine the contamination by leukocytes of purified erythrocytes from human blood, 20 µl of whole blood was mixed with 10 ml of RPMI 1640, and the mixture was passed through a leukocyte isolation filter.

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Host Response and Inflammation: Accumulation of Plasmodium berghei-Infected Red Blood Cells in the Brain Is Crucial for the Development of Cerebral Malaria in Mice

August 18, 2010 - 15:02 -- Patrick Sampao
Author(s): 
Fernanda G. Baptista, Ana Pamplona, Ana C. Pena, Maria M. Mota, Sylviane Pied, and Ana M. Vigário
Reference: 
Infect. Immun., Sep 2010; 78: 4033 - 4039.

Importantly, these results also demonstrated that the experimental cerebral malaria model shares many features with human pathology and might be a relevant model to study its pathogenesis.

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Downstream effects of haemoglobinase inhibition in Plasmodium falciparum-infected erythrocytes

July 19, 2010 - 10:04 -- Patrick Sampao
Author(s): 
Julie A. Naughton, Sima Nasizadeh, Angus Bell
Reference: 
Molecular and Biochemical Parasitology, Volume 173, Issue 2, October 2010, Pages 81-87

In this study we examined the downstream effects of reduced haemoglobin digestion on osmoprotection and nutrition. We found that inhibitors of haemoglobinases (plasmepsins, falcipains and aminopeptidases) did not cause premature haemolysis.

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