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vivax malaria

Pharmacokinetics/pharmacodynamics of chloroquine and artemisinin-based combination therapy with primaquine

September 24, 2019 - 14:59 -- Open Access
Author(s): 
André Daher, Ghait Aljayyoussi, David G. Lalloo, et al.
Reference: 
Malaria Journal 2019 18:325, 23 September 2019

Activation of hypnozoites of vivax malaria causes multiple clinical relapses, which contribute to the Plasmodium vivax burden and continuing transmission. Artemisinin-based combination therapy (ACT) is effective against blood-stage P. vivax but requires co-administration with primaquine to achieve radical cure. The therapeutic efficacy of primaquine depends on the generation of a therapeutically active metabolite via cytochrome P450 2D6 (CYP2D6). Impaired CYP2D6 metabolism has been associated with primaquine treatment failure. This study investigated the association between impaired CYP2D6 genotypes, drug-exposure to the long-acting ACT component (schizonticidal drugs) and tolerance and efficacy.

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Comparison of CareStartTM HRP2/pLDH COMBO rapid malaria test with light microscopy in northwest Ethiopia

July 24, 2012 - 11:13 -- Kabogo Ndegwa
Author(s): 
Moges B, Amare B, Belyhun Y, Tekeste Z, Gizachew M, Workineh M, Gebrehiwot A, Woldeyohannes D, Mulu A, Kassu A
Reference: 
Malaria Journal 2012, 11:234 (20 July 2012)

MalariaWorldThe CareStartTM RDT test showed good sensitivity and specificity with an excellent agreement to the reference light microscopy.

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Not Open Access | Status of Plasmodium vivax malaria in the Republic of Korea, 2008–2009: decrease followed by resurgence

June 11, 2012 - 15:02 -- Patrick Sampao
Author(s): 
Joon-Sup Yeom, Gyo Jun, Jung-Yeon Kim, Won-Ja Lee, E-Hyun Shin, Kyu-Sik Chang, Ji-Hwan Bang, Sejoong Oh, Joon-Young Kang, Jae-Won Park
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 106, Issue 7, July 2012, Pages 429-436

MalariaWorldThe number of Plasmodium vivaxmalaria cases in the Republic of Korea (ROK) in 2008 was 1009, a 54.2% decrease on the previous year. It then resurged to 1317 cases in 2009 (30.5% increase on 2008).

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Adverse effects of falciparum and vivax malaria and the safety of antimalarial treatment in early pregnancy: a population-based study

April 27, 2012 - 12:37 -- Patrick Sampao
Author(s): 
R McGready, SJ Lee, FH Nosten, et al.
Reference: 
The Lancet Infectious Diseases, Volume 12, Issue 5, May 2012, Pages 388-396

MalariaWorldWe analysed all antenatal records of women in the first trimester of pregnancy attending Shoklo Malaria Research Unit antenatal clinics from May 12, 1986, to Oct 31, 2010.

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Acute pancreatitis in a patient with vivax malaria.

March 15, 2012 - 14:11 -- Patrick Sampao
Author(s): 
Sharma V, Sharma A, Aggarwal A, Bhardwaj G, Aggarwal S.
Reference: 
JOP. 2012 Mar 10;13(2):215-6.

MalariaWorldWe present the case of a 17-year-old male who presented with a history of fever, abdominal pain and hypotension and revealing acute pancreatitis associated with infection by Plasmodium vivax.

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Open Access | Primaquine in vivax malaria: an update and review on management issues

December 14, 2011 - 08:17 -- Kabogo Ndegwa
Author(s): 
Fernando D, Rodrigo C, Rajapakse S
Reference: 
Malaria Journal 2011, 10:351 (12 December 2011)

MalariaWorldPrimaquine was officially licensed as an anti-malarial drug by the FDA in 1952. It has remained the only FDA licensed drug capable of clearing the intra-hepatic schizonts and hypnozoites of Plasmodium vivax.

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Open Access | Vivax malaria in Mauritania includes infection of a Duffy-negative individual

November 8, 2011 - 09:25 -- Kabogo Ndegwa
Author(s): 
Wurtz N, Lekweiry Mint K, Bogreau H, Pradines B, Rogier C, Salem Boukhary AO, Hafid JE, Ahmedou Salem MS, Trape J, Basco LK, Briolant S
Reference: 
Malaria Journal 2011, 10:336 (3 November 2011)

MalariaWorldThis study presents the Duffy blood group polymorphisms in Nouakchott City and demonstrates that in Mauritania, P. vivax is able to infect Duffy-negative patients.

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Open Access | Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand

May 10, 2011 - 08:01 -- Kabogo Ndegwa
Author(s): 
Marcus J Rijken, Machteld E Boel, Bruce Russell, Mallika Imwong, Mara L Leimanis, Aung Pyae Phyo, Atis Muehlenbachs, Niklas Lindegardh, Rose McGready, Laurent Renia, Georges Snounou, Pratap Singhasivanon, Francois Nosten
Reference: 
Malaria Journal 2011, 10:113 (5 May 2011)

Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations.

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Confirmed Vivax Resistance to Chloroquine and Effectiveness of Artemether-Lumefantrine for the Treatment of Vivax Malaria in Ethiopia

January 10, 2011 - 07:55 -- Patrick Sampao
Author(s): 
Ambachew M. Yohannes, Awash Teklehaimanot, Yngve Bergqvist and Pascal Ringwald
Reference: 
Am J Trop Med Hyg, Jan 2011; 84: 137 - 140.

Chloroquine (CQ) is still the drug of choice for the treatment of vivax malaria in Ethiopia, whereas artemether-lumefantrine (AL) is for falciparum malaria. In this setting, clinical malaria cases are treated with AL.

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Open Access | Anopheles culicifacies breeding in brackish waters in Sri Lanka and implications for malaria control

May 5, 2010 - 08:47 -- Kabogo Ndegwa
Author(s): 
Jude PJ, Dharshini S, Vinobaba M, Surendran SN, Ramasamy R
Reference: 
Malaria Journal 2010, 9:106 (21 April 2010)

The study demonstrates the ability of An. culicifacies species E, the major vector of falciparum and vivax malaria in Sri Lanka, to oviposit and breed in brackish water. The sibling species B in the An. subpictus complex, a well-known salt water breeder and a secondary malaria vector in the country, was also detected at the same site. Since global warming and the rise in sea levels will further increase of inland brackish water bodies, the findings have significant implications for the control of malaria in Sri Lanka and elsewhere.

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