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Lack of Molecular Correlates of Plasmodium vivax Ookinete Development

August 4, 2011 - 13:58 -- Patrick Sampao
Viengngeun Bounkeua, Fengwu Li, Raul Chuquiyauri, Shira R. Abeles, Colleen M. McClean, Victor Neyra, Alejandro Llanos-Cuentas, Pablo P. Yori and Joseph M. Vinetz
Am J Trop Med Hyg 2011 vol. 85 no. 2 207-213

Two methods for production of P. vivax ookinete cultures in vitro, with yields of 106 macrogametocytes, 104 zygotes, and 103 ookinetes, respectively, per 10 mL of P. vivax-infected patient blood with approximately 0.01% parasitemia, were used to study P. vivax sexual stage development.

Medical Condition: 

Adenovirus-vectored Plasmodium vivax ookinete surface protein, Pvs25, as a potential transmission-blocking vaccine

March 9, 2011 - 08:38 -- Patrick Sampao
Takeshi Miyata., Tetsuya Harakuni., Takeshi Arakawa., et al.
Vaccine, Volume 29, Issue 15, 24 March 2011, Pages 2720-2726

This study, the first preclinical evaluation of adenovirus-vectored malaria OSPs, implicates a potential inclusion of malaria transmission-blocking vaccine antigens in viral vector systems.

Medical Treatment: 

ADF2 is required for transformation of the ookinete and sporozoite in malaria parasite development

July 12, 2010 - 13:16 -- Kabogo Ndegwa
Yuko Doi, Naoaki Shinzawa, Shinya Fukumoto, Hideyuki Okano, Hirotaka Kanuka
Biochemical and Biophysical Research Communications, Volume 397, Issue 4, 9 July 2010, Pages 668-672

Malaria parasites undergo two rounding-up transformations in their life cycle: the ookinete-to-oocyst transformation in the mosquito midgut, and the sporozoite-to-EEF (exo-erythrocytic form) differentiation in the host hepatocyte.

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