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Plasmodium berghei

In vitro and in vivo antimalarial evaluation of semi-synthetic derivatives of gomphostenin

June 29, 2010 - 11:56 -- Kabogo Ndegwa
Author(s): 
Manisha Sathe, M.P. Kaushik
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 14, 15 July 2010, Pages 4233-4236

A novel series of semi-synthetic gomphostenin derivatives (1–9) were prepared utilizing C-14 hydroxyl group for the first time and studied for their antimalarial properties.

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In vivo antimalarial evaluation of Gomphostenins

June 23, 2010 - 12:20 -- Patrick Sampao
Author(s): 
M. Sathe, R. Ghorpade, A.K. Srivastava, M.P. Kaushik
Reference: 
Journal of Ethnopharmacology, Volume 130, Issue 1, 6 July 2010, Pages 171-174

The studies have indicated that clerodane class of diterpenes GN–6 and GN–10 certainly holds great promise for malaria control and will be useful in antimalarial chemotherapy.

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Open Access | Genome Wide Analysis of Inbred Mouse Lines Identifies a Locus Containing Ppar-γ as Contributing to Enhanced Malaria Survival

June 4, 2010 - 07:58 -- Kabogo Ndegwa
Author(s): 
Selina E. R. Bopp, Vandana Ramachandran, Kerstin Henson, Angelina Luzader, Merle Lindstrom, Muriel Spooner, Brian M. Steffy, Oscar Suzuki, Chris Janse, Andrew P. Waters, Yingyao Zhou, Tim Wiltshire, Elizabeth A. Winzeler
Reference: 
PLoS ONE 5(5): e10903.

The genetic background of a patient determines in part if a person develops a mild form of malaria and recovers, or develops a severe form and dies. We have used a mouse model to detect genes involved in the resistance or susceptibility to Plasmodium berghei malaria infection.

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Open Access | Comparison of Plasmodium berghei challenge models for the evaluation of pre-erythrocytic malaria vaccines and their effect on perceived vaccine efficacy

May 31, 2010 - 11:48 -- Kabogo Ndegwa
Author(s): 
Leitner WW, Bergmann-Leitner ES, Angov E
Reference: 
Malaria Journal 2010, 9:145 (27 May 2010)

The immunological mechanisms responsible for protection against malaria infection vary among Plasmodium species, host species and the developmental stage of parasite, and are poorly understood. A challenge with live parasites is the most relevant approach to testing the efficacy of experimental malaria vaccines.

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Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice

May 6, 2010 - 12:26 -- Kabogo Ndegwa
Author(s): 
Norinne Lacerda-Queiroz, David Henrique Rodrigues, Antônio Lúcio Teixeira, .et al
Reference: 
Experimental Parasitology, Volume 125, Issue 3, July 2010, Pages 271-278

Experimental cerebral malaria is a neuroinflammatory condition that results from the host immune response to the parasite.

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Assessment of in vivo antimalarial activity of rifampicin, isoniazide, and ethambutol combination therapy

May 3, 2010 - 09:42 -- Kabogo Ndegwa
Author(s): 
Nayak P. Aditya, Swati Patankar and Basavaraj Madhusudhan
Reference: 
Parasitology Research, Volume 106, Number 6 / May, 2010

The existing armament of drugs for the treatment and prevention of malaria is inadequate due to development of resistance.

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Open Access | Antiplasmodial activity of Ajuga bracteosa against Plasmodium berghei infected BALB/c mice

April 29, 2010 - 13:48 -- Kabogo Ndegwa
Author(s): 
Chandel S, Bagai U
Reference: 
Indian J Med Res. 2010 Mar;131:440-4

ELEAB inhibited parasitaemia and enhanced mean survival time in a dose- dependent manner upto 750 mg/kg/day dose in treated mice. Further studies need to be done to isolate and characterize active constituents of extract and to study their mechanism of action.

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Open Access | Functional Evaluation of Plasmodium Export Signals in Plasmodium berghei Suggests Multiple Modes of Protein Export

April 22, 2010 - 13:09 -- Kabogo Ndegwa
Author(s): 
Puran Singh Sijwali, Philip J. Rosenthal
Reference: 
PLoS ONE 5(4): e10227

Functional validation of common putative export domains of malaria parasites in P. berghei provides an alternative and simpler system to investigate export mechanisms.

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Immunity to infection: Blood-stage Plasmodium berghei infection leads to short-lived parasite-associated antigen presentation by dendritic cells

April 19, 2010 - 13:09 -- Kabogo Ndegwa
Author(s): 
RJ Lundie, LJ Young, GM Davey, JA Villadangos, FR Carbone, WR Heath, BS Crabb
Reference: 
European Journal of Immunology, Volume 9999 Issue 999A

Despite extensive evidence that Plasmodium species are capable of stimulating the immune system, the association of malaria with a higher incidence of other infectious diseases and reduced responses to vaccination against unrelated pathogens, suggests the existence of immune suppression.

Review: Fertilization is a novel attacking site for the transmission blocking of malaria parasites

March 31, 2010 - 09:39 -- Patrick Sampao
Author(s): 
Makoto Hirai, Toshiyuki Mori
Reference: 
Acta Tropica, Volume 114, Issue 3, June 2010, Pages 157-161

Although the parasite fertilization step has been considered as Achilles’ heel of parasite life cycle and thus a critical target for blocking malaria transmission in the mosquito, its molecular mechanisms are largely unknown.

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