The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10309 malaria professionals are enjoying the free benefits of MalariaWorld today

Plasmodium berghei

Fungal and Parasitic Infections: Protein Kinase C Deficiency Increases Resistance of C57BL/6J Mice to Plasmodium berghei Infection-Induced Cerebral Malaria

September 24, 2010 - 12:51 -- Patrick Sampao
Author(s): 
Ariel Ohayon, Jacob Golenser, Rosa Sinay, Ami Tamir, Amnon Altman, Yaakov Pollack, and Noah Isakov
Reference: 
Infect. Immun., Oct 2010; 78: 4195 - 4205.

We tested the consequences of PKC ablation on the host response to infection by Plasmodium berghei ANKA (PbA). We found that both PKC+/+ and PKC–/– C57BL/6J mice are susceptible to infection with PbA.

Open Access | Naturally Occurring Triggers that Induce Apoptosis-Like Programmed Cell Death in Plasmodium berghei Ookinetes

September 17, 2010 - 10:06 -- Kabogo Ndegwa
Author(s): 
Medhat Ali, Ebtesam M. Al-Olayan, Steven Lewis, Holly Matthews, Hilary Hurd
Reference: 
PLoS ONE 5(9): e12634

Several protozoan parasites have been shown to undergo a form of programmed cell death that exhibits morphological features associated with metazoan apoptosis. These include the rodent malaria parasite, Plasmodium berghei.

An early commitment to expression of a particular TCRVβ chain on CD8+ T cells responding to attenuated Plasmodium berghei sporozoites is maintained following challenge with infectious sporozoites

August 30, 2010 - 06:17 -- Kabogo Ndegwa
Author(s): 
J. M. Lumsden, M. A. Cranmer, U. Krzych
Reference: 
Parasite Immunology, Volume 32, Issue 9-10, pages 644–655, September/October 2010

Protection induced by irradiated Plasmodium berghei sporozoites (Pbγ-spz) in mice is linked to CD8+ T cells specific for exo-erythrocytic-stage Ags, and intrahepatic memory CD8+ T cells are associated with protracted protection.

Medical Condition: 
Medical Treatment: 

Open Access | Immunization with Pre-Erythrocytic Antigen CelTOS from Plasmodium falciparum Elicits Cross-Species Protection against Heterologous Challenge with Plasmodium berghei

August 26, 2010 - 14:40 -- Kabogo Ndegwa
Author(s): 
Elke S Bergmann-Leitner, Ryan M. Mease, Patricia De La Vega, Tatyana Savranskaya, Mark Polhemus, Christian Ockenhouse, Evelina Angov
Reference: 
PLoS ONE 5(8): e12294

Immunization with PfCelTOS resulted in potent humoral and cellular immune responses and most importantly induced sterile protection against a heterologous challenge with P. berghei sporozoites in a proportion of both inbred and outbred mice.

Medical Treatment: 

Host Response and Inflammation: Accumulation of Plasmodium berghei-Infected Red Blood Cells in the Brain Is Crucial for the Development of Cerebral Malaria in Mice

August 18, 2010 - 15:02 -- Patrick Sampao
Author(s): 
Fernanda G. Baptista, Ana Pamplona, Ana C. Pena, Maria M. Mota, Sylviane Pied, and Ana M. Vigário
Reference: 
Infect. Immun., Sep 2010; 78: 4033 - 4039.

Importantly, these results also demonstrated that the experimental cerebral malaria model shares many features with human pathology and might be a relevant model to study its pathogenesis.

Medical Treatment: 

Essential Role for IL-27 Receptor Signaling in Prevention of Th1-Mediated Immunopathology during Malaria Infection

August 5, 2010 - 11:56 -- Kabogo Ndegwa
Author(s): 
Emily Gwyer Findlay, Rachel Greig, Jason S. Stumhofer, Julius C. R. Hafalla, J. Brian de Souza, Christiaan J. Saris, Christopher A. Hunter, Eleanor M. Riley, and Kevin N. Couper
Reference: 
The Journal of Immunology, 2010, 185, 2482 -2492

Successful resolution of malaria infection requires induction of proinflammatory immune responses that facilitate parasite clearance; however, failure to regulate this inflammation leads to immune-mediated pathology.

Medical Treatment: 

Arp1, an actin-related protein, in Plasmodium berghei

July 19, 2010 - 09:47 -- Patrick Sampao
Author(s): 
Inga Siden-Kiamos, Herwig Schüler, Dimitris Liakopoulos, Christos Louis
Reference: 
Molecular and Biochemical Parasitology, Volume 173, Issue 2, October 2010, Pages 88-96

We present a phylogenetic and three-dimensional modelling analysis as well as cell biological and genetic data that support classification of this gene as being an orthologue of the actin-related protein 1 (Arp1).

Medical Condition: 

The Kennedy phospholipid biosynthesis pathways are refractory to genetic disruption in Plasmodium berghei and therefore appear essential in blood stages

July 19, 2010 - 09:40 -- Patrick Sampao
Author(s): 
Sandrine Déchamps, Kai Wengelnik, Laurence Berry-Sterkers, Rachel Cerdan, Henri J. Vial, Laila Gannoun-Zaki
Reference: 
Molecular and Biochemical Parasitology, Volume 173, Issue 2, October 2010, Pages 69-80

Here, we have studied the essential nature of the Kennedy pathways in Plasmodium berghei, a rodent malaria parasite. Sequence analysis of the P. berghei CEPT, CCT, ECT and CK enzymes revealed the presence of all catalytic domains and essential residues and motifs necessary for enzymatic activities.

Medical Condition: 

Dimeric cyclohexane-1,3-dione oximes inhibit wheat acetyl-CoA carboxylase and show anti-malarial activity

July 16, 2010 - 08:20 -- Kabogo Ndegwa
Author(s): 
Theola Louie, C. Dean Goodman, Georgina A. Holloway, Geoffrey I. McFadden, Vanessa Mollard, Keith G. Watson
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 15, 1 August 2010, Pages 4611-4613

A series of dimeric 1,3-cyclohexanedione oxime ethers were synthesized and found to have significant antiplasmodial activity with IC50’s in the range 3–12 μM.

Medical Treatment: 

ADF2 is required for transformation of the ookinete and sporozoite in malaria parasite development

July 12, 2010 - 13:16 -- Kabogo Ndegwa
Author(s): 
Yuko Doi, Naoaki Shinzawa, Shinya Fukumoto, Hideyuki Okano, Hirotaka Kanuka
Reference: 
Biochemical and Biophysical Research Communications, Volume 397, Issue 4, 9 July 2010, Pages 668-672

Malaria parasites undergo two rounding-up transformations in their life cycle: the ookinete-to-oocyst transformation in the mosquito midgut, and the sporozoite-to-EEF (exo-erythrocytic form) differentiation in the host hepatocyte.

Pages

Subscribe to RSS - Plasmodium berghei