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Plasmodium berghei

New imidazolidinedione derivatives as antimalarial agents

February 15, 2011 - 11:45 -- Kabogo Ndegwa
Liang Zhang, Ramadas Sathunuru, ThuLan Luong, Victor Melendez, Michael P. Kozar, Ai J. Lin
Bioorganic & Medicinal Chemistry, Volume 19, Issue 4, 15 February 2011, Pages 1541-1549

A series of new N-alky- and N-alkoxy-imidazolidinediones was prepared and assessed for prophylactic and radical curative activities in mouse and Rhesus monkey models.

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Plasmodium berghei ANKA: Erythropoietin activates neural stem cells in an experimental cerebral malaria model

January 20, 2011 - 12:08 -- Kabogo Ndegwa
Andrew Core, Casper Hempel, Jørgen A.L. Kurtzhals, Milena Penkowa
Experimental Parasitology, Volume 127, Issue 2, February 2011, Pages 500-505

Cerebral malaria (CM) causes substantial mortality and neurological sequelae in survivors, and no neuroprotective regimens are currently available for this condition.

Plasmodium berghei K173: Selection of resistance to naphthoquine in a mouse model

January 20, 2011 - 12:05 -- Kabogo Ndegwa
Hong Wang, Zhu-Chun Bei, Jing-Yan Wang, Wu-Chun Cao
Experimental Parasitology, Volume 127, Issue 2, February 2011, Pages 436-439

Naphthoquine (NQ), as a component of ARCO® which composed of NQ and artemisinin, is a new 4-aminoquinoline antimalarial synthesized by our institute.

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Open Access | CD4+ Natural Regulatory T Cells Prevent Experimental Cerebral Malaria via CTLA-4 When Expanded In Vivo

December 16, 2010 - 07:24 -- Kabogo Ndegwa
Ashraful Haque, Shannon E. Best, Fiona H. Amante, Seri Mustafah, Laure Desbarrieres, Fabian de Labastida, Tim Sparwasser, Geoffrey R. Hill, Christian R. Engwerda
PLoS Pathog 6(12): e1001221

Studies in malaria patients indicate that higher frequencies of peripheral blood CD4+ Foxp3+ CD25+ regulatory T (Treg) cells correlate with increased blood parasitemia.

Development of experimental cerebral malaria is independent of IL-23 and IL-17

December 1, 2010 - 04:44 -- Kabogo Ndegwa
Hidekazu Ishida, Chikako Matsuzaki-Moriya, Hajime Hisaeda, et al.
Biochemical and Biophysical Research Communications, Volume 402, Issue 4, 26 November 2010, Pages 790-795

Cerebral malaria (CM) is the most severe complication of Plasmodium infection. Although inappropriate immune responses to Plasmodium falciparum are reported as the major causes of CM, the precise mechanisms for development remain unclear.

Open Access | Population biology of malaria within the mosquito: density-dependent processes and potential implications for transmission-blocking interventions

November 16, 2010 - 11:53 -- Kabogo Ndegwa
Thomas S Churcher, Emma J Dawes, Robert E Sinden, George K Christophides, Jacob C Koella, Maria-Gloria Basanez
Malaria Journal 2010, 9:311 (4 November 2010)

A greater understanding of the development of the malaria parasite within the mosquito is required to fully evaluate the impact of TBIs.

Selective accumulation of a novel antimalarial rhodacyanine derivative, SSJ-127, in an organelle of Plasmodium berghei

November 3, 2010 - 09:59 -- Kabogo Ndegwa
Mayumi Ikegami-Kawai, Chika Arai, Yuko Ogawa, Ryohei Yanoshita, Masataka Ihara
Bioorganic & Medicinal Chemistry, Volume 18, Issue 22, 15 November 2010, Pages 7804-7808

SSJ-127, a novel antimalarial rhodacyanine derivative, has shown potent antimalarial activity against chloroquine-resistant Plasmodium strains in vitro and subcutaneous administration of SSJ-127 results in a complete cure of a mouse malaria model. SSJ-127 was detected by fluorescence microscopy in the mouse malaria parasites Plasmodium berghei after exposure of infected red blood cells to the compound in vitro and in vivo.

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Open Access | Identification and Characterization of a Liver Stage-Specific Promoter Region of the Malaria Parasite Plasmodium

October 30, 2010 - 12:37 -- Kabogo Ndegwa
Susanne Helm, Christine Lehmann, Andreas Nagel, Rebecca R. Stanway, Sebastian Horstmann, Manuel Llinas, Volker T. Heussler
PLoS ONE 5(10): e13653

During the blood meal of a Plasmodium-infected mosquito, 10 to 100 parasites are inoculated into the skin and a proportion of these migrate via the bloodstream to the liver where they infect hepatocytes.

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The effect of nitric oxide and hydrogen peroxide in the activation of the systemic immune response of Anopheles albimanus infected with Plasmodium berghei

October 22, 2010 - 06:24 -- Kabogo Ndegwa
Antonia Herrera-Ortiz, Jesús Martínez-Barnetche, Nienke Smit, Mario H. Rodriguez, Humberto Lanz-Mendoza
Developmental & Comparative Immunology Volume 35, Issue 1, January 2011, Pages 44-50

The expression of genes encoding the antimicrobial peptides (AMPs) attacin, cecropin and gambicin, as well as the effects of NO and H2O2 on their expression was investigated in midguts and fat bodies of Anopheles albimanus during the midgut infection with Plasmodium berghei.

Open Access | Sequestration and Tissue Accumulation of Human Malaria Parasites: Can We Learn Anything from Rodent Models of Malaria?

October 6, 2010 - 08:09 -- Kabogo Ndegwa
Blandine Franke-Fayard, Jannik Fonager, Anneke Braks, Shahid M. Khan, Chris J. Janse
PLoS Pathog 6(9): e1001032

The sequestration of Plasmodium falciparum–infected red blood cells (irbcs) in the microvasculature of organs is associated with severe disease; correspondingly, the molecular basis of irbc adherence is an active area of study.


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