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Plasmodium berghei

Short Technical Report: Small-scale in vitro culture and purification of Plasmodium berghei for transfection experiment

April 11, 2011 - 15:03 -- Patrick Sampao
Author(s): 
Voravuth Somsak, Somdet Srichairatanakool, Sumalee Kamchonwongpaisan, Yongyuth Yuthavong, Chairat Uthaipibull
Reference: 
Molecular and Biochemical Parasitology, Volume 177, Issue 2, June 2011, Pages 156-159

This small-scale protocol provides significant advantages, namely reduction of parasite sample, laboratory consumables and mice for transfection experiments.

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Open Access | Plasmodium Cysteine Repeat Modular Proteins 3 and 4 are essential for malaria parasite transmission from the mosquito to the host

April 5, 2011 - 08:12 -- Kabogo Ndegwa
Author(s): 
Douradinha B, Augustijn KD, Moore SG, Ramesar J, Mota MM, Waters AP, Janse CJ, Thompson J
Reference: 
Malaria Journal 2011, 10:71 (31 March 2011)

PCRMP3 and 4 play multiple roles during the Plasmodium life cycle; they are essential for the establishment of sporozoite infection in the mosquito salivary gland, and subsequently for development in hepatocytes.

Open Access | Plasmodium berghei ANKA infection increases Foxp3, IL-10 and IL-2 in CXCL-10 deficient C57BL/6 mice

March 29, 2011 - 08:00 -- Kabogo Ndegwa
Author(s): 
Sarfo BY, Wilson NO, Bond VC, Stiles JK
Reference: 
Malaria Journal 2011, 10:69 (28 March 2011)

The results indicate that in the absence of CXCL-10, the resulting up-regulation of Foxp3, IL-10 and IL-2 may be involved in attenuating the severity of fatal murine CM in CXCL-10-/- mice.

Amodiaquine analogues containing NO-donor substructures: Synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria

March 28, 2011 - 12:26 -- Kabogo Ndegwa
Author(s): 
Massimo Bertinaria, Stefano Guglielmo, Barbara Rolando, Marta Giorgis, Cristina Aragno, Roberta Fruttero, Alberto Gasco, Silvia Parapini, Donatella Taramelli, Yuri C. Martins, Leonardo J.M. Carvalho
Reference: 
European Journal of Medicinal Chemistry, Volume 46, Issue 5, May 2011, Pages 1757-1767

The synthesis and physico-chemical properties of novel compounds obtained by conjugation of amodiaquine with moieties containing either furoxan or nitrooxy NO-donor substructures are described.

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Beta Interferon Suppresses the Development of Experimental Cerebral Malaria

March 22, 2011 - 13:57 -- Patrick Sampao
Author(s): 
Craig N. Morrell, Kalyan Srivastava, AnneMarie Swaim, M. Teresa Lee, Jun Chen, Chandrashakaharam Nagineni, John J. Hooks, and Barbara Detrick
Reference: 
Infect. Immun., Apr 2011; 79: 1750 - 1758.

In this article, we report that IFN-β treatment leads to reduction of CXCL9 and ICAM-1 in the brain, reduction of T-cell CXCR3 expression, and downregulation of serum tumor necrosis factor alpha (TNF).

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Open Access | Development of the piggyBac transposable system for Plasmodium berghei and its application for random mutagenesis in malaria parasites

March 22, 2011 - 13:10 -- Patrick Sampao
Author(s): 
Jannik Fonager, Blandine MD Franke-Fayard , John H. Adams, Jai Ramesar, Onny Klop, Shahid M. Khan, Chris J. Janse and Andrew P. Waters
Reference: 
BMC Genomics 2011, 12:155

This study reports the development and application of the piggyBac transposition system for the rodent malaria parasite P. berghei and the evaluation of its potential as a tool in forward genetic studies. P. berghei is the most frequently used malaria parasite model in gene function analysis since phenotype screens throughout the complete Plasmodium life cycle are possible both in vitro and in vivo.

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Cutting Edge: Attrition of Plasmodium-Specific Memory CD8 T Cells Results in Decreased Protection That Is Rescued by Booster Immunization

March 22, 2011 - 11:32 -- Kabogo Ndegwa
Author(s): 
Nathan W. Schmidt and John T. Harty
Reference: 
The Journal of Immunology April 1, 2011 vol. 186 no. 7 3836-3840

Sterile protection against infection with Plasmodium sporozoites requires high numbers of memory CD8 T cells.

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Histopathological studies in two strains of semi-immune mice infected with Plasmodium berghei ANKA after chronic exposure

March 22, 2011 - 10:08 -- Kabogo Ndegwa
Author(s): 
Gideon Kofi Helegbe, Tetsuo Yanagi, Masachika Senba, Nguyen Tien Huy, Mohammed Nasir Shuaibu, Akiko Yamazaki, Mihoko Kikuchi, Michio Yasunami & Kenji Hirayama
Reference: 
Parasitology Research, Volume 108, Number 4, 807-814

To mimic a human malaria infection in the endemic condition, two strains of mice (Balb/c and CBA) were infected and treated several times to generate so-called semi-immune status.

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Synthesis and biological evaluation of benzimidazole-5-carbohydrazide derivatives as antimalarial, cytotoxic and antitubercular agents

March 15, 2011 - 07:38 -- Kabogo Ndegwa
Author(s): 
José Camacho, Arthur Barazarte, Neira Gamboa, Juan Rodrigues, Rosario Rojas, Abraham Vaisberg, Robert Gilman, Jaime Charris
Reference: 
Bioorganic & Medicinal Chemistry, Volume 19, Issue 6, 15 March 2011, Pages 2023-2029

A series of N′-substituted-2-(5-nitrofuran or 5-nitrothiophen-2-yl)-3H-benzo[d]imidazole-5-carbohydrazide derivatives were synthesized and investigated for their abilities to inhibit β-hematin formation, hemoglobin hydrolysis and in vivo for their antimalarial efficacy in rodent Plasmodium berghei.

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Open Access | Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria

March 2, 2011 - 11:15 -- Kabogo Ndegwa
Author(s): 
Bernardo S. Franklin, Sally T. Ishizaka, Ricardo T. Gazzinelli, et al.
Reference: 
PNAS March 1, 2011 vol. 108 no. 9 3689-3694

Excessive release of proinflammatory cytokines by innate immune cells is an important component of the pathogenic basis of malaria.

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