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Plasmodium berghei

Induction of pro-inflammatory mediators in Plasmodium berghei infected BALB/c mice breaks blood-brain-barrier and leads to cerebral malaria in an IL-12 dependent manner

August 1, 2011 - 14:54 -- Patrick Sampao
Author(s): 
Kim E. Schmidt, Beatrix Schumak, Sabine Specht, Bettina Dubben, Andreas Limmer, Achim Hoerauf
Reference: 
Microbes and Infection, Volume 13, Issue 10, September 2011, Pages 828-836

We show that ECM- resistant BALB/c mice were driven into interferon gamma- and IL-12-dependent ECM and subsequent death if they received CpG-oligonucleotides after Plasmodium berghei ANKA (PbA) infection.

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Open Access | Global proteomic analysis of plasma from mice infected with Plasmodium berghei ANKA using two dimensional gel electrophoresis and matrix assisted laser desorption ionization-time of flight mass spectrometry

July 28, 2011 - 08:30 -- Kabogo Ndegwa
Author(s): 
Gitau EN, Kokwaro GO, Newton CR, Ward SA
Reference: 
Malaria Journal 2011, 10:205 (26 July 2011)

Malaria-infection in mice results in a wide perturbation of the host serum proteome involving a range of proteins and functions.

Open Access | Short Report: Improvement of the observational method for Plasmodium berghei oocysts in the midgut of mosquitoes

June 29, 2011 - 13:21 -- Patrick Sampao
Author(s): 
Miho Usui, Shinya Fukumoto, Noboru Inoue and Shin-ichiro Kawazu
Reference: 
Parasites & Vectors 2011, 4:11, 27 June 2011

To evaluate the accuracy in the oocyst counting with the improved technique, mosquitoes were infected with the green fluorescent protein (GFP)-expressing parasite.

Short Communication: Characterization of Plasmodium berghei glutathione synthetase

June 27, 2011 - 12:48 -- Patrick Sampao
Author(s): 
S.K. Sharma, H.S. Banyal
Reference: 
Parasitology International, Volume 60, Issue 3, September 2011, Pages 321-323

Plasmodium berghei contained 0.454 ± 0.031 U/mg of glutathione synthetyase (GS). GS was purified using solid ammonium sulfate and Sephadex G-200 from P. berghei infected mouse erythrocytes.

Plasmodium berghei proteome changes in response to SSJ-183 treatment

June 23, 2011 - 07:25 -- Kabogo Ndegwa
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Author(s): 
Jun Lu, Chika Arai, Abu Bakar Md, Masataka Ihara
Reference: 
Bioorganic & Medicinal Chemistry, Volume 19, Issue 13, 1 July 2011, Pages 4144-4147

The benzo[a]phenoxazine derivative, SSJ-183 has shown excellent anti-malarial efficacy and safety.

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Open Access | Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice

June 10, 2011 - 12:30 -- Patrick Sampao
Author(s): 
Graziela M Zanini, Pedro Cabrales, Wisam Barkho, John A Frangos and Leonardo J M Carvalho
Reference: 
Journal of Neuroinflammation 2011, 8:66

These results indicate that the protective effect of exogenous NO on murine CM is associated with decreased brain vascular expression of inflammatory markers resulting in attenuated endothelial junction damage and facilitating blood flow.

Open Access | Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model

May 11, 2011 - 12:26 -- Patrick Sampao
Author(s): 
Wachiraporn Tipsuwan, Somdet Srichairatanakool, Sumalee Kamchonwongpaisan, Yongyuth Yuthavong, Chairat Uthaipibull
Reference: 
Malaria Journal 2011, 10:119 (10 May 2011)

This study demonstrated the power of the transgenic P. berghei system to predict drug-resistant Pfdhfr mutations in an in vivo parasite/host setting.

Plasmodium–Host Interactions Directly Influence the Threshold of Memory CD8 T Cells Required for Protective Immunity

May 5, 2011 - 06:34 -- Kabogo Ndegwa
Author(s): 
Nathan W. Schmidt, Noah S. Butler and John T. Harty
Reference: 
The Journal of Immunology May 15, 2011 vol. 186 no. 10 5873-5884

Plasmodium infections are responsible for millions of cases of malaria and ∼1 million deaths annually.

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High Parasite Burdens Cause Liver Damage in Mice following Plasmodium berghei ANKA Infection Independently of CD8+ T Cell-Mediated Immune Pathology

April 23, 2011 - 09:00 -- Patrick Sampao
Author(s): 
Ashraful Haque, Shannon E. Best, Christian R. Engwerda, et al.
Reference: 
Infect. Immun., May 2011; 79: 1882 - 1888.

These data indicate that CD8+ T cell-mediated immune pathology occurs in the brain but not the liver, while parasite-dependent pathology occurs in both organs during P. berghei ANKA infection.

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Gene profiling analysis reveals the contribution of CD24 and P2Y6R to the susceptibility of young rats to Plasmodium berghei infection

April 19, 2011 - 14:58 -- Patrick Sampao
Author(s): 
Christine Pierrot, Aurore Acroute dit Vampouille, Audrey Vandomme, Sophia Lafitte, Raymond J. Pierce, David Hot,Jamal Khalife
Reference: 
Cellular Microbiology, Volume 13, Issue 5, pages 752–763, May 2011

In conclusion, this study contributes to the discovery of novel biomarkers in young susceptible rats and suggests that the decrease in their expression could be among the reasons for the development of severe pathology in malaria.

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