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Plasmodium berghei

Open Access | Genome Comparison of Human and Non-Human Malaria Parasites Reveals Species Subset-Specific Genes Potentially Linked to Human Disease

December 28, 2011 - 06:55 -- Kabogo Ndegwa
Author(s): 
Christian Frech, Nansheng Chen
Reference: 
PLoS Comput Biol 7(12): e1002320

MalariaWorldGenes underlying important phenotypic differences between Plasmodium species, the causative agents of malaria, are frequently found in only a subset of species and cluster at dynamically evolving subtelomeric regions of chromosomes.

Ethnobotanical study of antimalarial plants in Shinile District, Somali Region, Ethiopia, and in vivo evaluation of selected ones against Plasmodium berghei

December 14, 2011 - 13:28 -- Patrick Sampao
Author(s): 
Akalu Mesfin, Mirutse Giday, Abebe Animut, Tilahun Teklehaymanot
Reference: 
Journal of Ethnopharmacology, Volume 139, Issue 1, 6 January 2012, Pages 221-227

MalariaWorldResults of this study can be used as a basis for further phytochemical and pharmacological investigations in the effort for search of new and locally affordable antimalarial agents.

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Open Access | Evaluation of immunity against malaria using luciferase-expressing Plasmodium berghei parasites

December 14, 2011 - 08:13 -- Kabogo Ndegwa
Author(s): 
Ploemen I, Behet M, Nganou-Makamdop K, van Gemert G, Bijker E, Hermsen C, Sauerwein R
Reference: 
Malaria Journal 2011, 10:350 (9 December 2011)

MalariaWorldPbGFP-Luccon parasites are a straightforward and valuable tool for comprehension of the biological and immunological principles underlying protection against malaria.

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Hepcidin Is Regulated during Blood-Stage Malaria and Plays a Protective Role in Malaria Infection

December 8, 2011 - 07:01 -- Kabogo Ndegwa
Author(s): 
Hai-Zhen Wang, Ying-Xin He, Chun-Ju Yang, Wei Zhou, and Cheng-Gang Zou
Reference: 
The Journal of Immunology December 15, 2011 vol. 187 no. 12 6410-6416

MalariaWorldHepcidin is one of the regulators of iron metabolism. The expression of hepcidin is induced in spleens and livers of mice infected with pathogenic bacteria.

A scalable pipeline for highly effective genetic modification of a malaria parasite

November 30, 2011 - 07:14 -- Kabogo Ndegwa
Author(s): 
Claudia Pfander, Burcu Anar, Frank Schwach, Thomas D Otto, Mathieu Brochet, Katrin Volkmann, Michael A Quail, Arnab Pain, Barry Rosen, William Skarnes, Julian C Rayner and Oliver Billker
Reference: 
Nature Methods, Volume: 8, Pages: 1078–1082, Year published: (2011)

MalariaWorldIn malaria parasites, the systematic experimental validation of drug and vaccine targets by reverse genetics is constrained by the inefficiency of homologous recombination and by the difficulty of manipulating adenine and thymine (A+T)-rich DNA of most Plasmodium species in Escherichia coli.

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Open Access | In vitro culture of Plasmodium berghei-ANKA maintains infectivity of mouse erythrocytes inducing cerebral malaria

November 29, 2011 - 10:01 -- Kabogo Ndegwa
Author(s): 
Jambou R, El-Assaad F, Combes V, Grau GE
Reference: 
Malaria Journal 2011, 10:346 (25 November 2011)

MalariaWorldUsing these settings, reinvasion of normal mouse erythrocytes by the parasite was obtained in vitro over two weeks with preservation of the infectivity in vivo.

Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections

November 29, 2011 - 09:47 -- Kabogo Ndegwa
Author(s): 
Cátia Ramalhete, Filipa P. da Cruz, Dinora Lopes, Silva Mulhovo, Virgílio E. Rosário, Miguel Prudêncio, Maria-José U. Ferreira
Reference: 
Bioorganic & Medicinal Chemistry, Volume 19, Issue 24, 15 December 2011, Pages 7474-7481

MalariaWorldBioassay-guided fractionation of the methanol extract of Momordica balsamina led to the isolation of two new cucurbitane-type triterpenoids, balsaminol F (1) and balsaminoside B (2), along with the known glycosylated cucurbitacins, cucurbita-5,24-diene-3β,23(R)-diol-7-O-β-d-glucopyranoside (3) and kuguaglycoside A (4).

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Experimentally controlled downregulation of the histone chaperone FACT in Plasmodium berghei reveals that it is critical to male gamete fertility

November 17, 2011 - 13:32 -- Patrick Sampao
Author(s): 
Eliane C. Laurentino, Sonya Taylor, Andrew P. Waters, et al.
Reference: 
Cellular Microbiology, Volume 13, Issue 12, pages 1956–1974, December 2011

MalariaWorldWe identified a Plasmodium berghei protein, termed FACT-L, with homology to the SPT16 subunit of FACT. Epitope tagging of FACT-L showed nuclear localization with high expression in the nuclei of (activated) male gametocytes.

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High-throughput multi-parameter flow-cytometric analysis from micro-quantities of Plasmodium-infected blood

November 16, 2011 - 09:03 -- Patrick Sampao
Author(s): 
Simon H. Apte, Penny L. Groves, Joanne S. Roddick, Vanusa P. da Hora, Denise L. Doolan
Reference: 
International Journal for Parasitology, Volume 41, Issue 12, October 2011, Pages 1285-1294

MalariaWorldHerein, we describe the technique and demonstrate its application in vaccinology and with a range of rodent and human parasite species including Plasmodium yoelii, Plasmodium chabaudi, Plasmodium berghei and Plasmodium falciparum.

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Open Access | Disruption of plasmepsin-4 and merozoites surface protein-7 genes in Plasmodium berghei induces combined virulence-attenuated phenotype

October 31, 2011 - 14:59 -- Patrick Sampao
Author(s): 
Roberta Spaccapelo, Elena Aime, Sara Caterbi, Paola Arcidiacono, Barbara Capuccini, Manlio Di Cristina,Tania Dottorini, Mario Rende, Francesco Bistoni & Andrea Crisanti
Reference: 
Scientific Reports Volume: 1:39

MalariaWorldThese observations provide a proof-of-concept step for the development of human malaria vaccines based on genetically attenuated blood-stage parasites.

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