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Plasmodium berghei

Open Access | Improved negative selection protocol for Plasmodium berghei in the rodent malarial model

April 4, 2012 - 13:51 -- Kabogo Ndegwa
Author(s): 
Orr RY, Philip N, Waters AP
Reference: 
Malaria Journal 2012, 11:103 (31 March 2012)

MalariaWorldAn improved methodology is presented here for transgenic Plasmodium berghei lines that express the negative selectable marker yFCU (a bifunctional protein that combines yeast cytosine deaminase and uridyl phosphoribosyl transferase (UPRT)) and substitutes delivery of selection drug 5-fluorocytosine (5FC) by intraperitoneal injection for administration via the drinking water of the mice.

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Open Access | Extracellular ATP triggers proteolysis and cytosolic Ca2+ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites

March 22, 2012 - 06:58 -- Kabogo Ndegwa
Author(s): 
Nogueira da Cruz L, Juliano M, Budu A, Juliano L, Holder AA, Blackman MJ, Garcia CR
Reference: 
Malaria Journal 2012, 11:69 (15 March 2012)

MalariaWorldThe data clearly show that purinergic signalling modulates P. berghei protease(s) activity and that MSP1 is one target in this pathway.

Short technical report: A GFP-Actin reporter line to explore microfilament dynamics across the malaria parasite lifecycle

March 14, 2012 - 07:49 -- Patrick Sampao
Author(s): 
Fiona Angrisano, Michael J. Delves, Angelika Sturm, Vanessa Mollard, Geoffrey I. McFadden, Robert E. Sinden, Jake Baum
Reference: 
Molecular and Biochemical Parasitology, Volume 182, Issues 1–2, March–April 2012, Pages 93–96

MalariaWorldHowever, following treatment with the actin filament-stabilizing drug Jasplakinolide, we show evidence for concentration of F-actin dynamics in the parasite pellicle and at polar apices.

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Open Access | Roles of the Amino Terminal Region and Repeat Region of the Plasmodium berghei Circumsporozoite Protein in Parasite Infectivity

March 6, 2012 - 08:00 -- Kabogo Ndegwa
Author(s): 
Cassandra Aldrich, Alessandro Magini, Carla Emiliani, Tania Dottorini, Francesco Bistoni, Andrea Crisanti, Roberta Spaccapelo
Reference: 
PLoS ONE 7(2): e32524

MalariaWorldThe circumsporozoite protein (CSP) plays a key role in malaria sporozoite infection of both mosquito salivary glands and the vertebrate host.

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Open Access | Bacterium-like particles as multi-epitope delivery platform for Plasmodium berghei circumsporozoite protein induce complete protection against malaria in mice

February 28, 2012 - 12:37 -- Patrick Sampao
Author(s): 
Nganou-Makamdop K, van Roosmalen ML, Audouy SA, van Gemert G, Leenhouts K, Hermsen CC, Sauerwein RW
Reference: 
Malaria Journal 2012, 11:50 (20 February 2012)

MalariaWorldThe present study reports the immunogenicity and protective efficacy of bacterium-like particles (BLPs) generated from Lactococcus lactis and loaded with Plasmodium berghei circumsporozoite protein (PbCSP) peptides.

Antiplasmodial activity of Xanthium strumarium against Plasmodium berghei-infected BALB/c mice

February 23, 2012 - 15:36 -- Kabogo Ndegwa
Author(s): 
Sanjeev Chandel, Upma Bagai & Nisha Vashishat
Reference: 
Parasitology Research, Volume 110, Number 3, 1179-1183

MalariaWorldThe present work was undertaken to evaluate the antiplasmodial activity of ethanolic leaves extract of traditional medicinal plant Xanthium strumarium in Plasmodium berghei-infected BALB/c mice along with phytochemical screening and acute toxicity test to support its traditional medicinal use as a malaria remedy.

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Open Access | Efficacy of Different Nitric Oxide-Based Strategies in Preventing Experimental Cerebral Malaria by Plasmodium berghei ANKA

February 23, 2012 - 09:08 -- Kabogo Ndegwa
Author(s): 
Yuri C. Martins, Graziela M. Zanini, John A. Frangos, Leonardo J. M. Carvalho
Reference: 
PLoS ONE 7(2): e32048

MalariaWorldThese data show that sildenafil lowers the amount of NO-donor needed to prevent ECM, resulting also in lesser side effects.

Flow cytometric enumeration of Plasmodium berghei-infected red blood cells stained with SYBR Green I

February 15, 2012 - 15:08 -- Patrick Sampao
Author(s): 
Voravuth Somsak, Somdet Srichairatanakool, Yongyuth Yuthavong, Sumalee Kamchonwongpaisan, Chairat Uthaipibull
Reference: 
Acta Tropica, Volume 122, Issue 1, April 2012, Pages 113-118

MalariaWorldThis protocol was validated in an antimalarial assay and the result was comparable to that obtained from conventional microscopic counting. The SYBR Green I flow cytometric protocol is thus a rapid and precise tool for high-throughput in vivo antimalarial drug screening.

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IL-12Rβ2 Is Essential for the Development of Experimental Cerebral Malaria

February 7, 2012 - 14:02 -- Kabogo Ndegwa
Author(s): 
Mathilde Fauconnier, Jennifer Palomo, Valérie F. J. Quesniaux, et al.
Reference: 
The Journal of Immunology February 15, 2012 vol. 188 no. 4 1905-1914

MalariaWorldA Th1 response is required for the development of Plasmodium berghei ANKA (PbA)-induced experimental cerebral malaria (ECM).

The antiplasmodial activity of Anogeissus leiocarpus and its effect on oxidative stress and lipid profile in mice infected with Plasmodium bergheii

January 11, 2012 - 08:37 -- Kabogo Ndegwa
Author(s): 
Olusegun Matthew Akanbi, Akhere A. Omonkhua, Christianah M. Cyril-Olutayo & Rotimi Yemi Fasimoye
Reference: 
Parasitology Research, Volume 110, Number 1, 219-226

MalariaWorldMethanolic extracts of Anogeissus leiocarpus has been considered locally to have the same antimalarial activities as artemisinin derivatives.

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