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Plasmodium berghei

Open Access | Suppressive effect of azithromycin on Plasmodium berghei mosquito stage development and apicoplast replication

March 14, 2010 - 10:23 -- Ingeborg van Schayk
Shoichi Shimizu, Yoshio Osada, Tamotsu Kanazawa, Yoshiya Tanaka, Meiji Arai
Malaria Journal 2010, 9:73 (10 March 2010)

AZM inhibits parasite development in the mosquito stage, probably through the same mechanism as in the liver and blood stages. Such a multi-targeting anti-malarial, along with its safety, would be ideal for mass drug administration in malaria control programmes.

Open Access | Transmission blocking activity of a standardized neem (Azadirachta indica) seed extract on the rodent malaria parasite Plasmodium berghei in its vector Anopheles stephensi

March 7, 2010 - 13:02 -- Ingeborg van Schayk
Leonardo Lucantoni, Rakiswende S Yerbanga, Giulio Lupidi, Luciano Pasqualini, Fulvio Esposito, Annette Habluetzel
Malaria Journal 2010, 9:66 (2 March 2010)

These results and evidence of anti-plasmodial activity of neem products accumulated over the last years encourage to convey neem compounds into the drug discovery & development pipeline and to evaluate their potential for the design of novel or improved transmission-blocking remedies.

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Analgesic and antimalarial activities of crude leaf extract and fractions of Acalypha wilkensiana

January 21, 2010 - 07:46 -- Kabogo Ndegwa
John A. Udobanga, Paul A. Nwafora and Jude E. Okokon
Journal of Ethnopharmacology Volume 127, Issue 2, 3 February 2010, Pages 373-378

Antiplasmodial and analgesic activities of leaf extract and fractions of Acalypha wilkensiana were evaluated to ascertain the folkloric claim of its antimalarial and analgesic activities.

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Changes in cell migration-related molecules expressed by thymic microenvironment during experimental Plasmodium berghei infection: consequences on thymocyte development

January 10, 2010 - 16:25 -- Ingeborg van Schayk
Jacy Gameiro, Patrícia R. A. Nagib, Carolina F. Andrade, Déa M. S. Villa-Verde, Suse D. Silva-Barbosa, Wilson Savino, Fábio T. M. Costa, Liana Verinaud
Immunology, Volume 129 Issue 2, Pages 248 - 256

Overall, we show that the thymic atrophy observed in P. berghei-infected mice is accompanied by thymic microenvironmental changes that comprise altered expression of thymocyte migration-related molecules of the ECM and chemokine protein families, which in turn can alter the thymocyte migration pattern.

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Plasmepsin 4-Deficient Plasmodium berghei Are Virulence Attenuated and Induce Protective Immunity against Experimental Malaria

December 30, 2009 - 08:13 -- Patrick Sampao
Roberta Spaccapelo, Chris J. Janse, Sara Caterbi, Blandine Franke-Fayard{dagger, J. Alfredo Bonilla, Luke M. Syphard, Manlio Di Cristina, Tania Dottorini, Andrea Savarino, Antonio Cassone, Francesco Bistoni, Andrew P. Waters, John B. Dame and Andrea Crisanti
American Journal of Pathology. 2010; 176:205-217

Parasite blood-stage attenuation should help identify protective immune responses against malaria, unravel parasite-derived factors involved in malarial pathologies, such as cerebral malaria, and potentially pave the way for blood-stage whole organism vaccines.

Synthesis and structure–activity relationships of cassiarin A as potential antimalarials with vasorelaxant activity.

November 18, 2009 - 12:54 -- Kabogo Ndegwa
Hiroshi Morita, Yuichiro Tomizawa, Jun Deguchi, Tokio Ishikawa, Hiroko Arai, Kazumasa Zaima, Takahiro Hosoya, Yusuke Hirasawa, Takayuki Matsumoto, Katsuo Kamata, Wiwied Ekasari, Aty Widyawaruyanti, Tutik Sri Wahyuni, Noor Cholies Zaini, Toshio Honda.
Bioorganic & Medicinal Chemistry, Volume 17, Issue 24, 15 December 2009, Pages 8234-8240, doi:10.1016/j.bmc.2009.10.013

Cassiarin A 1, a tricyclic alkaloid, isolated from the leaves of Cassia siamea (Leguminosae), shows powerful antimalarial activity against Plasmodium falciparum in vitro as well as P. berghei in vivo, which may be valuable leads for novel antimalarials.

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