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Plasmodium berghei

Not Open Access | Conformational co-dependence between Plasmodium berghei LCCL proteins promotes complex formation and stability

October 1, 2012 - 17:26 -- Patrick Sampao
Author(s): 
Sadia Saeed, Annie Z. Tremp, Johannes T. Dessens
Reference: 
Molecular and Biochemical Parasitology, Volume 185, Issue 2, October 2012, Pages 170-173

MalariaWorld Here, we investigate this in Plasmodium berghei by crossing a PbLAP1 null mutant parasite with a parasite line expressing GFP-tagged PbLAP3 that displays strong fluorescence in gametocytes.

Not Open Access | Critical roles of the mitochondrial complex II in oocyst formation of rodent malaria parasite Plasmodium berghei

September 4, 2012 - 14:45 -- Patrick Sampao
Author(s): 
Akina Hino, Makoto Hirai, Takeshi Q. Tanaka, Yoh-ichi Watanabe, Hiroyuki Matsuoka and Kiyoshi Kita
Reference: 
J Biochem (2012) 152 (3): 259-268.

MalariaWorldThese results suggest that malaria parasite may switch the energy metabolism from glycolysis to oxidative phosphorylation to adapt to the insect vector where glucose is not readily available for ATP production.

NOT Open Access | Novel 4-Aminoquinoline Analogs Highly Active against the Blood and Sexual Stages of Plasmodium In Vivo and In Vitro

August 22, 2012 - 06:43 -- Kabogo Ndegwa
Author(s): 
Fabián E. Sáenz, Tina Mutka, Kenneth Udenze, Ayoade M. J. Oduola, and Dennis E. Kyle
Reference: 
Antimicrob. Agents Chemother. September 2012 vol. 56 no. 9 4685-4692

MalariaWorldNew drugs to treat malaria must act rapidly and be highly potent against asexual blood stages, well tolerated, and affordable to residents of regions of endemicity.

Proteomic analysis of Plasmodium in the mosquito: progress and pitfalls

August 15, 2012 - 09:31 -- Kabogo Ndegwa
Author(s): 
M. N. Wass, R. Stanway, A. M. Blagborough, K. Lal, J. H. Prieto, D. Raine, M. J. E. Sternberg, A. M. Talman, F. Tomley, J. Yates, R. E. Sinden
Reference: 
Parasitology, Volume 139, Special Issue 09, August 2012, pp 1131-1145

MalariaWorldHere we discuss proteomic analyses of whole cell preparations of the mosquito stages of malaria parasite development (i.e. gametocytes, microgamete, ookinete, oocyst and sporozoite) of Plasmodium berghei.

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NOT Open Access | Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy

August 15, 2012 - 09:17 -- Kabogo Ndegwa
Author(s): 
Makoah N. Aminake, Aman Mahajan, Kelly Chibale, et al.
Reference: 
Bioorganic & Medicinal Chemistry, Volume 20, Issue 17, 1 September 2012, Pages 5277–5289

MalariaWorldMalaria and HIV are among the most important global health problems of our time and together are responsible for approximately 3 million deaths annually.

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NOT Open Access | Expansion of experimental genetics approaches for Plasmodium berghei with versatile transfection vectors

July 23, 2012 - 14:00 -- Patrick Sampao
Author(s): 
Taco W.A. Kooij, Manuel M. Rauch, Kai Matuschewski
Reference: 
Molecular and Biochemical Parasitology, Volume 185, Issue 1, September 2012, Pages 19-26

MalariaWorldWe show that stable integration into a transgene expression site, an intergenic locus at a synteny breakpoint on P. berghei chromosome 6, is phenotypically silent and generated a bright green fluorescent parasite line for imaging applications.

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Distinct placental malaria pathology caused by different Plasmodium berghei lines that fail to induce cerebral malaria in the C57Bl/6 mouse

July 20, 2012 - 12:52 -- Kabogo Ndegwa
Author(s): 
Rodrigues-Duarte L, Vieira de Moraes L, Barboza R, Marinho CR, Franke-Fayard B, Janse CJ, Penha-Goncalves C
Reference: 
Malaria Journal 2012, 11:231 (16 July 2012)

MalariaWorldInfection of pregnant C57BL/6 females with K173, NK65 and ANKADeltapm4 P. berghei parasites provide experimental systems to identify host molecular components involved in PM pathogenesis mechanisms.

NOT Open Access | Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice

June 20, 2012 - 13:21 -- Kabogo Ndegwa
Author(s): 
N.P. Aditya, Geetanjali Chimote, Karthigayan Gunalan, Rinti Banerjee, Swati Patankar, Basavaraj Madhusudhan
Reference: 
Experimental Parasitology, Volume 131, Issue 3, July 2012, Pages 292–299

MalariaWorldCurcuminoids are poorly water-soluble compounds with promising antimalarial activity.

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New Agilent platform DNA microarrays for transcriptome analysis of Plasmodium falciparum and Plasmodium berghei for the malaria research community

June 13, 2012 - 15:09 -- Patrick Sampao
Author(s): 
Kafsack BF, Painter HJ, Llinás M
Reference: 
Malaria Journal 2012, 11:187 (8 June 2012)

MalariaWorldWith the aim of alleviating some of these factors next-generation DNA microarrays for genome-wide transcriptome analysis for both Plasmodium falciparum and Plasmodium berghei using the Agilent 8x15K platform were designed.

NOT Open Access | Improved Plasmodium berghei lines for conditional mutagenesis

May 23, 2012 - 10:03 -- Patrick Sampao
Author(s): 
Dhruv Panchal, Kavitha Govindasamy, Arti Rana, Purnima Bhanot
Reference: 
Molecular and Biochemical Parasitology, Volume 184, Issue 1, July 2012, Pages 52-54

MalariaWorldWe describe improved lines of P. berghei with stably integrated DNA recombinase that allow efficient, stage-specific excision of target genes in the widely used ANKA strain.

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