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Plasmodium berghei

In vivo compartmental kinetics of Plasmodium falciparum histidine-rich protein II in the blood of humans and in BALB/c mice infected with a transgenic Plasmodium berghei parasite expressing histidine-rich protein II

March 13, 2019 - 14:44 -- Open Access
Author(s): 
Kristin E. Poti, Amanda E. Balaban, Priya Pal, Tamaki Kobayashi, Daniel E. Goldberg, Photini Sinnis and David J. Sullivan
Reference: 
Malaria Journal 2019 18:78, 13 March 2019

The data suggest that persistence of PfHRP2 is due to slower clearance of protein from the RBC fraction of the whole blood.

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NOT Open Access | Stearylamine Liposomal Delivery of Monensin in Combination with Free Artemisinin Eliminates Blood Stages of Plasmodium falciparum in Culture and P. berghei Infection in Murine Malaria

March 5, 2016 - 23:47 -- NOT Open Access
Author(s): 
Vinoth Rajendran, Shilpa Rohra, Mohsin Raza, Gulam Mustafa Hasan, Suparna Dutt, and Prahlad C. Ghosh
Reference: 
Antimicrob. Agents Chemother. March 2016 vol. 60 no. 3 1304-1318

The global emergence of drug resistance in malaria is impeding the therapeutic efficacy of existing antimalarial drugs.

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Synergistic anti-malarial action of cryptolepine and artemisinins

February 18, 2016 - 09:47 -- Open Access
Author(s): 
Arnold D. Forkuo, Charles Ansah, Kwesi M. Boadu, Johnson N. Boampong, Elvis O. Ameyaw, Ben A. Gyan, Andrea T. Arku and Michael F. Ofori
Reference: 
Malaria Journal 2016 15:89, 16 February 2016

The combination of CPE with the artemisinin derivatives were safe in the rodent model and showed a synergistic anti-malarial activity in vivo and in vitro.

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NOT Open Access | Global transcriptional repression: An initial and essential step for Plasmodium sexual development

October 14, 2015 - 10:39 -- NOT Open Access
Author(s): 
Masao Yuda, Shiroh Iwanaga, Izumi Kaneko, and Tomomi Kato
Reference: 
PNAS October 13, 2015 vol. 112 no. 41 12824-12829

Gametocytes are nonreplicative sexual forms that mediate malaria transmission to a mosquito vector.

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Not Open Access | Reduced Plasmodium berghei sporozoite liver load associates with low protective efficacy after intradermal immunization

November 25, 2012 - 13:52 -- NOT Open Access
Author(s): 
K. NGANOU-MAKAMDOP, I. PLOEMEN, M. BEHET, G.-J. VAN GEMERT, C. HERMSEN, M. ROESTENBERG, R. W. SAUERWEIN
Reference: 
Parasite Immunology, Volume 34, Issue 12, pages 562–569, December 2012
MalariaWorld

We investigated in a murine model the protective efficacy and immune responses after ID or IV immunization of sporozoites.

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Agrochemicals against Malaria, Sleeping Sickness, Leishmaniasis and Chagas Disease

November 12, 2012 - 08:15 -- Open Access
Author(s): 
Matthias Witschel, Matthias Rottmann, Marcel Kaiser, Reto Brun
Reference: 
PLoS Negl Trop Dis 6(10): e1805
MalariaWorld

In tropical regions, protozoan parasites can cause severe diseases with malaria, leishmaniasis, sleeping sickness, and Chagas disease standing in the forefront.

Not Open Access | Development of Memory CD8+ T Cells and Their Recall Responses during Blood-Stage Infection with Plasmodium berghei ANKA

October 23, 2012 - 17:33 -- Patrick Sampao
Author(s): 
Mana Miyakoda, Daisuke Kimura, Kiri Honma, Kazumi Kimura, Masao Yuda, and Katsuyuki Yui
Reference: 
J Immunol 2012;189 4396-4404

MalariaWorldThese results suggest that memory CD8+ T cells can be established postinfection with P. berghei ANKA, but their recall responses during reinfection are more profoundly inhibited than responses of naive CD8+ T cells.

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Not Open Access | Conformational co-dependence between Plasmodium berghei LCCL proteins promotes complex formation and stability

October 1, 2012 - 17:26 -- Patrick Sampao
Author(s): 
Sadia Saeed, Annie Z. Tremp, Johannes T. Dessens
Reference: 
Molecular and Biochemical Parasitology, Volume 185, Issue 2, October 2012, Pages 170-173

MalariaWorld Here, we investigate this in Plasmodium berghei by crossing a PbLAP1 null mutant parasite with a parasite line expressing GFP-tagged PbLAP3 that displays strong fluorescence in gametocytes.

Not Open Access | Critical roles of the mitochondrial complex II in oocyst formation of rodent malaria parasite Plasmodium berghei

September 4, 2012 - 14:45 -- Patrick Sampao
Author(s): 
Akina Hino, Makoto Hirai, Takeshi Q. Tanaka, Yoh-ichi Watanabe, Hiroyuki Matsuoka and Kiyoshi Kita
Reference: 
J Biochem (2012) 152 (3): 259-268.

MalariaWorldThese results suggest that malaria parasite may switch the energy metabolism from glycolysis to oxidative phosphorylation to adapt to the insect vector where glucose is not readily available for ATP production.

NOT Open Access | Novel 4-Aminoquinoline Analogs Highly Active against the Blood and Sexual Stages of Plasmodium In Vivo and In Vitro

August 22, 2012 - 06:43 -- Kabogo Ndegwa
Author(s): 
Fabián E. Sáenz, Tina Mutka, Kenneth Udenze, Ayoade M. J. Oduola, and Dennis E. Kyle
Reference: 
Antimicrob. Agents Chemother. September 2012 vol. 56 no. 9 4685-4692

MalariaWorldNew drugs to treat malaria must act rapidly and be highly potent against asexual blood stages, well tolerated, and affordable to residents of regions of endemicity.

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