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Plasmodium berghei

NOT Open Access | Mice chronically fed a high-fat diet are resistant to malaria induced by Plasmodium berghei ANKA

October 1, 2019 - 14:33 -- NOT Open Access
Author(s): 
Onésia Cristina Oliveira-Lima, Natália Lourenço Almeida, Camila Megale Almeida-Leite & Juliana Carvalho-Tavares
Reference: 
Parasitology Research, October 2019, Volume 118, Issue 10, pp 2969–2977

C57BL/6 mice infected with Plasmodium berghei ANKA (PbA) develop neurological symptoms and die 6-–7-day post-inoculation in the absence of high parasitemia.

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Transcriptome analysis of Plasmodium berghei during exo-erythrocytic development

September 30, 2019 - 13:40 -- Open Access
Author(s): 
Reto Caldelari, Sunil Dogga, Marc W. Schmid, Blandine Franke-Fayard, Chris J. Janse, Dominique Soldati-Favre and Volker Heussler
Reference: 
Malaria Journal 2019 18:330, 24 September 2019

The complex life cycle of malaria parasites requires well-orchestrated stage specific gene expression. In the vertebrate host the parasites grow and multiply by schizogony in two different environments: within erythrocytes and within hepatocytes. Whereas erythrocytic parasites are well-studied in this respect, relatively little is known about the exo-erythrocytic stages.

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Improvement of an in vitro drug selection method for generating transgenic Plasmodium berghei parasites

July 1, 2019 - 15:48 -- Open Access
Author(s): 
Akira Soga, Takahiro Shirozu, Mami Ko-ketsu and Shinya Fukumoto
Reference: 
Malaria Journal 2019 18:215, 25 June 2019

Reverse genetics approaches have become powerful tools to dissect the biology of malaria parasites. In a previous study, development of an in vitro drug selection method for generating transgenic parasite of Plasmodium berghei was reported. Using this method, two novel and independent selection markers using the P. berghei heat shock protein 70 promoter was previously established. While the approach permits the easy and flexible genetic manipulation of P. berghei, shortcomings include a low variety in promoter options to drive marker gene expression and increased complexity of the selection procedure. In this study, addressing these issues was attempted.

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In vivo compartmental kinetics of Plasmodium falciparum histidine-rich protein II in the blood of humans and in BALB/c mice infected with a transgenic Plasmodium berghei parasite expressing histidine-rich protein II

March 13, 2019 - 14:44 -- Open Access
Author(s): 
Kristin E. Poti, Amanda E. Balaban, Priya Pal, Tamaki Kobayashi, Daniel E. Goldberg, Photini Sinnis and David J. Sullivan
Reference: 
Malaria Journal 2019 18:78, 13 March 2019

The data suggest that persistence of PfHRP2 is due to slower clearance of protein from the RBC fraction of the whole blood.

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NOT Open Access | Stearylamine Liposomal Delivery of Monensin in Combination with Free Artemisinin Eliminates Blood Stages of Plasmodium falciparum in Culture and P. berghei Infection in Murine Malaria

March 5, 2016 - 23:47 -- NOT Open Access
Author(s): 
Vinoth Rajendran, Shilpa Rohra, Mohsin Raza, Gulam Mustafa Hasan, Suparna Dutt, and Prahlad C. Ghosh
Reference: 
Antimicrob. Agents Chemother. March 2016 vol. 60 no. 3 1304-1318

The global emergence of drug resistance in malaria is impeding the therapeutic efficacy of existing antimalarial drugs.

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Synergistic anti-malarial action of cryptolepine and artemisinins

February 18, 2016 - 09:47 -- Open Access
Author(s): 
Arnold D. Forkuo, Charles Ansah, Kwesi M. Boadu, Johnson N. Boampong, Elvis O. Ameyaw, Ben A. Gyan, Andrea T. Arku and Michael F. Ofori
Reference: 
Malaria Journal 2016 15:89, 16 February 2016

The combination of CPE with the artemisinin derivatives were safe in the rodent model and showed a synergistic anti-malarial activity in vivo and in vitro.

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NOT Open Access | Global transcriptional repression: An initial and essential step for Plasmodium sexual development

October 14, 2015 - 10:39 -- NOT Open Access
Author(s): 
Masao Yuda, Shiroh Iwanaga, Izumi Kaneko, and Tomomi Kato
Reference: 
PNAS October 13, 2015 vol. 112 no. 41 12824-12829

Gametocytes are nonreplicative sexual forms that mediate malaria transmission to a mosquito vector.

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Not Open Access | Reduced Plasmodium berghei sporozoite liver load associates with low protective efficacy after intradermal immunization

November 25, 2012 - 13:52 -- NOT Open Access
Author(s): 
K. NGANOU-MAKAMDOP, I. PLOEMEN, M. BEHET, G.-J. VAN GEMERT, C. HERMSEN, M. ROESTENBERG, R. W. SAUERWEIN
Reference: 
Parasite Immunology, Volume 34, Issue 12, pages 562–569, December 2012
MalariaWorld

We investigated in a murine model the protective efficacy and immune responses after ID or IV immunization of sporozoites.

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Agrochemicals against Malaria, Sleeping Sickness, Leishmaniasis and Chagas Disease

November 12, 2012 - 08:15 -- Open Access
Author(s): 
Matthias Witschel, Matthias Rottmann, Marcel Kaiser, Reto Brun
Reference: 
PLoS Negl Trop Dis 6(10): e1805
MalariaWorld

In tropical regions, protozoan parasites can cause severe diseases with malaria, leishmaniasis, sleeping sickness, and Chagas disease standing in the forefront.

Not Open Access | Development of Memory CD8+ T Cells and Their Recall Responses during Blood-Stage Infection with Plasmodium berghei ANKA

October 23, 2012 - 17:33 -- Patrick Sampao
Author(s): 
Mana Miyakoda, Daisuke Kimura, Kiri Honma, Kazumi Kimura, Masao Yuda, and Katsuyuki Yui
Reference: 
J Immunol 2012;189 4396-4404

MalariaWorldThese results suggest that memory CD8+ T cells can be established postinfection with P. berghei ANKA, but their recall responses during reinfection are more profoundly inhibited than responses of naive CD8+ T cells.

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