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Open Access | Invited Speaker Presentation: Retinopathy and microcirculation in adult severe malaria

November 3, 2010 - 13:15 -- Patrick Sampao
Author(s): 
Richard James Maude, Abdullah Abu Sayeed, Arjen M Dondorp et al.
Reference: 
Malaria Journal 2010, 9(Suppl 2):I7 (20 October 2010)

A specific retinopathy has been described in African children with cerebral malaria, but in adults this has not been extensively studied.

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Open Access | Inhibition of Plasmodium falciparum Field Isolates-Mediated Endothelial Cell Apoptosis by Fasudil: Therapeutic Implications for Severe Malaria

October 18, 2010 - 09:12 -- Patrick Sampao
Author(s): 
Estelle S., Ulrick B., et al.
Reference: 
PLoS ONE 5(10): e13221.

We therefore assessed herein whether Fasudil would have a similar efficiency on P. falciparum taken directly from malaria patients using contact and non-contact experiments. Seven (23.3%) of 30 PRBC preparations from different patients were apoptogenic, four (13.3%) acting by cytoadherence and three (10%) via soluble factors.

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Open Access | Severe Imported Falciparum Malaria: A Cohort Study in 400 Critically Ill Adults

October 18, 2010 - 08:52 -- Patrick Sampao
Author(s): 
Fabrice B., Florence T., et al.
Reference: 
PLoS ONE 5(10): e13236.

Data from 400 adults admitted to the intensive care unit were analysed, representing the largest series of severe imported malaria to date. Median age was 45 years; 60% of patients were white, 96% acquired the disease in sub-Saharan Africa, and 65% had not taken antimalarial chemoprophylaxis.

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