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Open Access | Invited Speaker Presentation: Insights from monkey malaria that can change thinking about human infections

November 3, 2010 - 12:27 -- Patrick Sampao
Author(s): 
Janet Cox-Singh
Reference: 
Malaria Journal 2010, 9(Suppl 2):I2 (20 October 2010)

Despite prolonged and intense effort to understand and control the health impact of malaria morbidity and mortality, malaria remains third in the global ranking for severe and fatal infections.

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Brief Report: Outpatient Upper Respiratory Tract Viral Infections in Children with Malaria Symptoms in Western Kenya

November 1, 2010 - 13:48 -- Patrick Sampao
Author(s): 
John N., Jane K., et al.
Reference: 
Am J Trop Med Hyg, Nov 2010; 83: 1010 - 1013.

A cross-sectional study was performed in children 5 through 10 years of age presenting to outpatient clinics in Nyanza Province, Kenya, in which nasal swab and blood specimens were collected during the high malaria transmission season.

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Review: Efficacy and safety of chloroquine for treatment in patients with uncomplicated Plasmodium vivax infections in endemic countries

October 22, 2010 - 09:55 -- Patrick Sampao
Author(s): 
Cho Naing, Kyan Aung, Daw-Khin Win, Mak Joon Wah
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 11, November 2010, Pages 695-705

The objective of this review is to summarize the existing evidence on the relative efficacy and safety of CQ in treating patients with uncomplicated P. vivax malaria in endemic countries.

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Gametocyte sex ratio in single-clone infections of the malaria parasite Plasmodium mexicanum

October 18, 2010 - 10:04 -- Patrick Sampao
Author(s): 
A.T. Neal, J.J. Schall
Reference: 
Parasitology, Volume 137, Issue 13, November 2010, pp 1851 - 1859

We examined these issues with a study of experimental single-clone infections for the lizard malaria parasite Plasmodium mexicanum in its natural host.

2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections

October 18, 2010 - 09:25 -- Patrick Sampao
Author(s): 
Deniz T., David S., et al.
Reference: 
Bioorganic & Medicinal Chemistry, Volume 18, Issue 21, 1 November 2010, Pages 7475-7485

This is the first study to indicate therapeutic potential of HDAs against various parasitic protozoa. It also points out that the malarial liver stage growth inhibitory effect of the 2-HDA may be promoted via PfFAS-II enzymes.

Open Access | A large proportion of asymptomatic Plasmodium infections with low and sub-microscopic parasite densities in the low transmission setting of Temotu Province, Solomon Islands: challenges for malaria diagnostics in an elimination setting

September 9, 2010 - 12:43 -- Patrick Sampao
Author(s): 
Harris I, Sharrock WW, Bain LM, Gray K, Bobogare A, Boaz L, Lilley K, Krause D, Vallely A, Johnson M, Gatton ML, Shanks GD, Cheng Q
Reference: 
Malaria Journal 2010, 9:254 (7 September 2010)

During the survey, 9,491 blood samples were collected and examined by microscopy for Plasmodium species and density, with a subset also examined by polymerase chain reaction (PCR) and rapid diagnostic tests (RDTs).

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Characterization of immune responses to single or mixed infections with P. yoelii 17XL and P. chabaudi AS in different strains of mice

August 9, 2010 - 13:35 -- Patrick Sampao
Author(s): 
Guang Chen, Hui Feng, Jun Liu, Zan-mei Qi, Yi Wu, Sheng-yu Guo, Dong-mei Li, Ji-chun Wang, Ya-ming Cao
Reference: 
Parasitology International, Volume 59, Issue 3, September 2010, Pages 400-406

To understand the consequence of co-infection with P.y17XL and P.cAS, we determined the proliferation curve of parasites, pro-inflammatory/anti-inflammatory cytokine profiles, and the dynamic changes of the number of Tregs in DBA/2 and BALB/c mice with single or mixed-species infections.

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Open Access | Review: TLR9 and endogenous adjuvants of the whole blood-stage malaria vaccine

July 19, 2010 - 12:41 -- Kabogo Ndegwa
Author(s): 
C Coban, T Horii, S Akira, KJ Ishii
Reference: 
Expert Review of Vaccines July 2010, Vol. 9, No. 7, Pages 775-784

Vaccination has been a successful tool in the protection against many infectious diseases, and recent advances in biotechnology have created new techniques and strategies to produce safe and efficacious vaccines for human use.

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Comparative Diagnosis of Malaria Infections by Microscopy, Nested PCR, and LAMP in Northern Thailand

July 2, 2010 - 12:54 -- Patrick Sampao
Author(s): 
Birgit Pöschl, Jarurin Waneesorn, Oriel Thekisoe, Salakchit Chutipongvivate, AND Karanis Panagiotis
Reference: 
Am J Trop Med Hyg, Jul 2010; 83: 56 - 60.

This study further validates LAMP as an alternative molecular diagnostic tool, which can be used in the diagnosis of early infections of malaria cases and together with nPCR can also be used as supplementary methods for clinical and epidemiological use.

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