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Defining the Role of Mutations in Plasmodium vivax Dihydrofolate Reductase-Thymidylate Synthase Gene Using an Episomal Plasmodium falciparum Transfection System

August 18, 2010 - 13:05 -- Kabogo Ndegwa
Alyson M. Auliff, John H. Adams, Michael T. O'Neil, and Qin Cheng
Antimicrobial Agents and Chemotherapy, September 2010, p. 3927-3932, Vol. 54, No. 9

Plasmodium vivax resistance to antifolates is prevalent throughout Australasia and is caused by point mutations within the parasite dihydrofolate reductase (DHFR)-thymidylate synthase. Several unique mutations have been reported in P. vivax DHFR, and their roles in resistance to classic and novel antifolates are not entirely clear due, in part, to the inability to culture P. vivax in vitro.

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Prevalence of 5′ insertion mutants and analysis of single nucleotide polymorphism in the erythrocyte binding-like 1 (ebl-1) gene in Kenyan Plasmodium falciparum field isolates

June 30, 2010 - 15:11 -- Patrick Sampao
Elijah K. Githui, David S. Peterson, Rashid A. Aman, Abdirahman I. Abdi
Infection, Genetics and Evolution, Volume 10, Issue 6, August 2010, Pages 833-838

This study is now extended to include field isolates collected from sites within Kenya. DNA isolated from blood samples of infected patients was utilized to amplify the region I sequence of ebl-1 gene in order to investigate polymorphism in the region immediately adjacent to the 5′ cysteine-rich domains, and to determine the prevalence of an insertion mutant that effectively knocks out the gene.

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