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Open Access | Bacterium-like particles as multi-epitope delivery platform for Plasmodium berghei circumsporozoite protein induce complete protection against malaria in mice

February 28, 2012 - 12:37 -- Patrick Sampao
Nganou-Makamdop K, van Roosmalen ML, Audouy SA, van Gemert G, Leenhouts K, Hermsen CC, Sauerwein RW
Malaria Journal 2012, 11:50 (20 February 2012)

MalariaWorldThe present study reports the immunogenicity and protective efficacy of bacterium-like particles (BLPs) generated from Lactococcus lactis and loaded with Plasmodium berghei circumsporozoite protein (PbCSP) peptides.

The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host

February 17, 2011 - 15:01 -- Patrick Sampao
Alida Coppi., Ramya Natarajan., Photini Sinnis., et al.
The Journal of Experimental Medicine.

These data provide structure–function information relevant to malaria vaccine development.


Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and αDEC-CSP in non human primates

October 11, 2010 - 14:45 -- Patrick Sampao
Kavita T., Barbara J., et al.
Vaccine, Volume 28, Issue 45, 21 October 2010, Pages 7256-7266

Here to assess these variables, non human primates (NHP) were immunized three times with Plasmodium falciparum (Pf) circumsporozoite protein (CSP) or CSP cloned into MG38, a monoclonal antibody that targets DEC-205 (αDEC-CSP), an endocytic receptor on dendritic cells (DCs).

Medical Treatment: 

Open Access | Plasmodium vivax circumsporozoite genotypes: a limited variation or new subspecies with major biological consequences?

June 24, 2010 - 09:57 -- Kabogo Ndegwa
Souza-Neiras WC, Storti-Melo LM, Cassiano GC, Couto VS, Couto AA, Soares IS, Carvalho LH, Cunha MG, Povoa MM, Herrera S, Herrera MA, Rossit AR, Carareto CM, Machado RL
Malaria Journal 2010, 9:178 (23 June 2010)

This results target that the differences among the P. vivax CS variants are restrict to the central repeated region of the protein, mostly nucleotide variation with important serological consequences.

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