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erythrocytes

Not Open Access | Purinoceptor signaling in malaria-infected erythrocytes

July 13, 2012 - 08:08 -- Patrick Sampao
Author(s): 
Stephan M. Huber
Reference: 
Microbes and Infection, Volume 14, Issue 10, August 2012, Pages 779-786

MalariaWorldThis review summarizes the pivotal function of purinergic signaling in erythrocyte control of vascular tone, in hemolytic septicemia, and in malaria.

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Open Access | Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes

June 8, 2011 - 15:06 -- Patrick Sampao
Author(s): 
Audrey Sicard, Jean-Philippe Semblat, Christian Doerig, et al
Reference: 
Cellular Microbiology, Volume 13, Issue 6, pages 836–845, June 2011

Here, we report that a protein kinase-mediated signalling pathway involving host RBC PAK1 and MEK1, which do not have orthologues in the Plasmodium kinome, is selectively stimulated in Plasmodium falciparum-infected (versus uninfected) RBCs, as determined by the use of phospho-specific antibodies directed against the activated forms of these enzymes.

Open Access | Rapid and Highly Sensitive Detection of Malaria-Infected Erythrocytes Using a Cell Microarray Chip

October 17, 2010 - 14:55 -- Patrick Sampao
Author(s): 
Shouki Yatsushiro, Shohei Yamamura, Yuka Yamaguchi, Yasuo Shinohara, Eiichi Tamiya, Toshihiro Horii, Yoshinobu Baba, Masatoshi Kataoka
Reference: 
PLoS ONE 5(10): e13179.

To examine the contamination by leukocytes of purified erythrocytes from human blood, 20 µl of whole blood was mixed with 10 ml of RPMI 1640, and the mixture was passed through a leukocyte isolation filter.

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Open Access | Surface Co-Expression of Two Different PfEMP1 Antigens on Single Plasmodium falciparum-Infected Erythrocytes Facilitates Binding to ICAM1 and PECAM1

September 9, 2010 - 12:07 -- Patrick Sampao
Author(s): 
Louise J., Dominique C., et al.
Reference: 
PLoS Pathogens Volume 6 Issue 9 September 02, 2010

These new results on PfEMP1 antigen expression indicate that a re-evaluation of the molecular mechanisms involved in P. falciparum adhesion and of the accepted paradigm of absolutely mutually exclusive var gene transcription is required.

Downstream effects of haemoglobinase inhibition in Plasmodium falciparum-infected erythrocytes

July 19, 2010 - 10:04 -- Patrick Sampao
Author(s): 
Julie A. Naughton, Sima Nasizadeh, Angus Bell
Reference: 
Molecular and Biochemical Parasitology, Volume 173, Issue 2, October 2010, Pages 81-87

In this study we examined the downstream effects of reduced haemoglobin digestion on osmoprotection and nutrition. We found that inhibitors of haemoglobinases (plasmepsins, falcipains and aminopeptidases) did not cause premature haemolysis.

On the Cytoadhesion of Plasmodium vivax-Infected Erythrocytes

July 16, 2010 - 14:17 -- Kabogo Ndegwa
Author(s): 
BO Carvalho, SC Lopes, FT Costa, et al.
Reference: 
The Journal of Infectious Diseases 2010;202: 638–647

These observations prompt a modification of the current paradigms of the pathogenesis of malaria and clear the way to investigate the pathophysiology of P. vivax infections.

Cellular Immunology and Immune Regulation: Cross-Talk between T Cells and NK Cells Generates Rapid Effector Responses to Plasmodium falciparum-Infected Erythrocytes

May 31, 2010 - 12:22 -- Kabogo Ndegwa
Author(s): 
Amir Horowitz, Kirsty C. Newman, J. Henry Evans, Daniel S. Korbel, Daniel M. Davis, and Eleanor M. Riley
Reference: 
J. Immunol., Jun 2010; 184: 6043 – 6052

Rapid cell-mediated immune responses, characterized by production of proinflammatory cytokines, such as IFN-{gamma}, can inhibit intraerythrocytic replication of malaria parasites and thereby prevent onset of clinical malaria.

Cellular Immunilogy and Immune Regulation: Cross-Talk between T Cells and NK Cells Generates Rapid Effector Responses to Plasmodium falciparum-Infected Erythrocytes

May 19, 2010 - 09:17 -- Kabogo Ndegwa
Author(s): 
Amir Horowitz, Kirsty C. Newman, J. Henry Evans, Daniel S. Korbel, Daniel M. Davis, and Eleanor M. Riley
Reference: 
The Journal of Immunology, 2010, 184, 6043 -6052

Rapid cell-mediated immune responses, characterized by production of proinflammatory cytokines, such as IFN-{gamma}, can inhibit intraerythrocytic replication of malaria parasites and thereby prevent onset of clinical malaria.

Open Access | Parameterization of high magnetic field gradient fractionation columns for applications with Plasmodium falciparum infected human erythrocytes

May 5, 2010 - 13:02 -- Patrick Sampao
Author(s): 
Karl S, Davis TM, St. Pierre TG
Reference: 
Malaria Journal 2010, 9:116 (3 May 2010)

A detailed quantitative analysis of a batchwise magnetic fractionation process for malaria infected erythrocytes using high gradient magnetic fractionation columns was performed. The models applied in this study allow the prediction of capture efficiency if the initial infected cell concentration and the flow rate are known.

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Immunization with VAR2CSA-DBL5 Recombinant Protein Elicits Broadly Cross-Reactive Antibodies to Placental Plasmodium falciparum-Infected Erythrocytes

April 19, 2010 - 14:31 -- Patrick Sampao
Author(s): 
Marion A., Megan M., et al
Reference: 
Infection and Immunity Vol. 78, No. 5, p. 2248-2256, May 2010

These findings demonstrate that the major PfEMP1 variant expressed by placental isolates exposes strain-transcendent epitopes that can be targeted by vaccination and may have application for pregnancy malaria vaccine development.

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