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World Health Organization, Geneva, 22 May 2019
Algeria and Argentina have been officially recognized by WHO as malaria-free. The certification is granted when a country proves that it has interrupted indigenous transmission of the disease for at least 3 consecutive years.
We are a group of four MSc students from the TU Delft in the Netherlands and working on a new mosquito bait to kill mosquitos and reduce the spreading- and infection of malaria. In order to further develop the prorotypes, test them in Kenya and ensure successful implementation, we set up a crowdfunding campaign.
The Compendium of WHO malaria guidance provides, for the first time, a complete list of all formal WHO policy recommendations on malaria in a single resource. The document also serves as a catalogue of all WHO publications on malaria prevention, diagnosis, treatment, surveillance and elimination.
Gene drive mosquitoes are a novel approach to vector control being developed to help tackle malaria. A gene drive increases the frequency of a desired gene and its phenotypic effect into a mosquito population through reproduction in relatively few generations . Combining gene drive with the precision of gene editing, scientists are able to modify the Anopheles mosquito genome and push modifications through natural vector populations.
We evaluated markers of sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum among 254 returned migrant workers in China from Africa from 2013 to 2016.
During the intraerythrocytic asexual cycle malaria parasites acquire nutrients and other solutes through a broad selectivity channel localized at the membrane of the infected erythrocyte termed the plasmodial surface anion channel (PSAC). The protein product of the Plasmodium falciparum clonally variant clag3.1 and clag3.2 genes determines PSAC activity. Switches in the expression of clag3 genes, which are regulated by epigenetic mechanisms, are associated with changes in PSAC-dependent permeability that can result in resistance to compounds toxic for the parasite, such as blasticidin S. Here, we investigated whether other antimalarial drugs require CLAG3 to reach their intracellular target and consequently are prone to parasite resistance by epigenetic mechanisms.
The repetitive interspersed family (RIFIN) and the subtelomeric variable open reading frame (STEVOR) family represent two of three major Plasmodium falciparum variant surface antigen families involved in malaria pathogenesis and immune evasion and are potential targets in the development of natural immunity. Protein and peptide microarrays populated with RIFINs and STEVORs associated with severe malaria vulnerability in Malian children were probed with adult and pediatric sera to identify epitopes that reflect malaria exposure.