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Guest editorial: “End Malaria for Good”- a few key messages based on the Cambodian experience

June 23, 2016 - 07:27 -- Bart G.J. Knols
The editorial below was contributed by Sara E Canavati and Jack S Richards. Contact details below.
World Malaria Day (WMD) is an international observance established in 2007 and commemorated every year on 25 April to recognize global efforts to control malaria. The theme for 2016 was “End Malaria For Good”, which focused on malaria elimination. Following the great progress made under the Millennium Development Goals, it is important to continue building on this success as we transition into the Sustainable Development Goals [1] and the recently launched Global Technical Strategy for Malaria (GTS) [2]. The aim of the piece is to briefly reflect on WMD 2016 and consider a few key operational issues on malaria elimination that may lie ahead for the coming year.

Algeria and Argentina certified malaria-free by WHO

May 22, 2019 - 17:03 -- Malaria World

World Health Organization, Geneva, 22 May 2019
Algeria and Argentina have been officially recognized by WHO as malaria-free. The certification is granted when a country proves that it has interrupted indigenous transmission of the disease for at least 3 consecutive years.

Job: Postdoctoral Fellow Malaria resistance research

May 13, 2019 - 09:21 -- MalariaWorld Jobs

Organisation: Institut Pasteur de la Guyane
Department: Parasitology laboratory, WHO Collaborating Center for Surveillance of Antimalarial Drug Resistance, National Reference Center for Malaria resistance
Location: Cayenne, French Guiana
Application deadline: May 31, 2019 (position open until filled)

Nosquito Bait: A new malaria vector control solution

May 10, 2019 - 11:03 -- Malaria World

We are a group of four MSc students from the TU Delft in the Netherlands and working on a new mosquito bait to kill mosquitos and reduce the spreading- and infection of malaria. In order to further develop the prorotypes, test them in Kenya and ensure successful implementation, we set up a crowdfunding campaign.

Compendium of WHO malaria guidance – prevention, diagnosis, treatment, surveillance and elimination

May 8, 2019 - 16:36 -- Malaria World

The Compendium of WHO malaria guidance provides, for the first time, a complete list of all formal WHO policy recommendations on malaria in a single resource. The document also serves as a catalogue of all WHO publications on malaria prevention, diagnosis, treatment, surveillance and elimination.

Read the The Compendium of WHO malaria guidance

Knowledge engagement in gene drive research for malaria control

April 30, 2019 - 15:29 -- Open Access
Sarah Hartley, Delphine Thizy, Katie Ledingham, Mamadou Coulibaly, Abdoulaye Diabaté, Bakara Dicko, Samba Diop, Jonathan Kayondo, Annet Namukwaya, Barry Nourou, Léa Paré Toé
PLoS Negl Trop Dis 13(4): e0007233

Gene drive mosquitoes are a novel approach to vector control being developed to help tackle malaria. A gene drive increases the frequency of a desired gene and its phenotypic effect into a mosquito population through reproduction in relatively few generations [1]. Combining gene drive with the precision of gene editing, scientists are able to modify the Anopheles mosquito genome and push modifications through natural vector populations. 

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NOT Open Access | Mutation Profile of pfdhfr and pfdhps in Plasmodium falciparum among Returned Chinese Migrant Workers from Africa

April 30, 2019 - 15:18 -- NOT Open Access
Chao Xu, Hui Sun, Qingkuan Wei, Jin Li, Ting Xiao, Xiangli Kong, Yongbin Wang, Guihua Zhao, Longjiang Wang, Gongzhen Liu, Ge Yan, Bingcheng Huang and Kun Yin
Antimicrob. Agents Chemother. April 2019 63:e01927-18

We evaluated markers of sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum among 254 returned migrant workers in China from Africa from 2013 to 2016.

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NOT Open Access | Identification of Antimalarial Compounds That Require CLAG3 for Their Uptake by Plasmodium falciparum-Infected Erythrocytes

April 30, 2019 - 15:17 -- NOT Open Access
Sofía Mira-Martínez, Anastasia K. Pickford, Núria Rovira-Graells, Pieter Guetens, Elisabet Tintó-Font, Alfred Cortés and Anna Rosanas-Urgell
Antimicrob. Agents Chemother. April 2019 63:e00052-19

During the intraerythrocytic asexual cycle malaria parasites acquire nutrients and other solutes through a broad selectivity channel localized at the membrane of the infected erythrocyte termed the plasmodial surface anion channel (PSAC). The protein product of the Plasmodium falciparum clonally variant clag3.1 and clag3.2 genes determines PSAC activity. Switches in the expression of clag3 genes, which are regulated by epigenetic mechanisms, are associated with changes in PSAC-dependent permeability that can result in resistance to compounds toxic for the parasite, such as blasticidin S. Here, we investigated whether other antimalarial drugs require CLAG3 to reach their intracellular target and consequently are prone to parasite resistance by epigenetic mechanisms. 

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Antibodies to Peptides in Semiconserved Domains of RIFINs and STEVORs Correlate with Malaria Exposure

April 30, 2019 - 15:03 -- Open Access
Albert E. Zhou, Andrea A. Berry, Mark A. Travassos, et al.
mSphere March/April 2019 4:e00097-19

The repetitive interspersed family (RIFIN) and the subtelomeric variable open reading frame (STEVOR) family represent two of three major Plasmodium falciparum variant surface antigen families involved in malaria pathogenesis and immune evasion and are potential targets in the development of natural immunity. Protein and peptide microarrays populated with RIFINs and STEVORs associated with severe malaria vulnerability in Malian children were probed with adult and pediatric sera to identify epitopes that reflect malaria exposure.

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