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Guest editorial: “End Malaria for Good”- a few key messages based on the Cambodian experience

June 23, 2016 - 07:27 -- Bart G.J. Knols
The editorial below was contributed by Sara E Canavati and Jack S Richards. Contact details below.
 
World Malaria Day (WMD) is an international observance established in 2007 and commemorated every year on 25 April to recognize global efforts to control malaria. The theme for 2016 was “End Malaria For Good”, which focused on malaria elimination. Following the great progress made under the Millennium Development Goals, it is important to continue building on this success as we transition into the Sustainable Development Goals [1] and the recently launched Global Technical Strategy for Malaria (GTS) [2]. The aim of the piece is to briefly reflect on WMD 2016 and consider a few key operational issues on malaria elimination that may lie ahead for the coming year.

Multiplex malaria antigen detection by bead-based assay and molecular confirmation by PCR shows no evidence of Pfhrp2 and Pfhrp3 deletion in Haiti

December 3, 2019 - 15:31 -- Open Access
Author(s): 
Camelia Herman, Curtis S. Huber, Sophie Jones, Laura Steinhardt, Mateusz M. Plucinski, Jean F. Lemoine, Michelle Chang, John W. Barnwell, Venkatachalam Udhayakumar and Eric Rogier
Reference: 
Malaria Journal 2019 18:380, 27 November 2019

The Plasmodium falciparum parasite is the only human malaria that produces the histidine-rich protein 2 and 3 (HRP2/3) antigens. Currently, HRP2/3 are widely used in malaria rapid diagnostic tests (RDTs), but several global reports have recently emerged showing genetic deletion of one or both of these antigens in parasites. Deletion of these antigens could pose a major concern for P. falciparum diagnosis in Haiti which currently uses RDTs based solely on the detection of the HRP2/3 antigens.

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Ultrasensitive and label-free biosensor for the detection of Plasmodium falciparum histidine-rich protein II in saliva

November 27, 2019 - 16:18 -- Open Access
Author(s): 
Soraya GV, Abeyrathne CD, Buffet C, Huynh DH, Uddin SM, Chan J, Skafidas E, Kwan P, Rogerson SJ
Reference: 
Sci Rep. 2019 Nov 25;9(1):17495

Malaria elimination is a global public health priority. To fulfil the demands of elimination diagnostics, we have developed an interdigitated electrode sensor platform targeting the Plasmodium falciparum Histidine Rich Protein 2 (PfHRP2) protein in saliva samples. A protocol for frequency-specific PfHRP2 detection in phosphate buffered saline was developed, yielding a sensitivity of 2.5 pg/mL based on change in impedance magnitude of the sensor.

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NOT Open Access | Sniffing animals as a diagnostic tool in infectious diseases

November 19, 2019 - 06:31 -- NOT Open Access
Author(s): 
Cambau E, Poljak M.
Reference: 
Clin Microbiol Infect. 2019 Nov 14

Scents and odours characterise some microbes when grown in the laboratory, and experienced clinicians can diagnose patients with some infectious diseases based on their smell. Animal sniffing is an innate behaviour, and animals’ olfactory acuity is used for detecting people, weapons, bombs, narcotics and food.

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NOT Open Access | Estimation of Malaria-Attributable Fever in Malaria Test-Positive Febrile Outpatients in Three Provinces of Mozambique, 2018

November 12, 2019 - 16:13 -- NOT Open Access
Author(s): 
Plucinski MM, Candrinho B, Dimene M, Smith T, Thwing J, Colborn J, Rogier E, Zulliger R.
Reference: 
Am J Trop Med Hyg. 2019 Nov 4

Like most malaria-endemic countries, Mozambique relies on tabulation of confirmed malaria test–positive febrile patients to track incidence of malaria. However, this approach is potentially biased by incidental malaria parasitemia in patients with fever of another etiology.

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Modelled and observed mean and seasonal relationships between climate, population density and malaria indicators in Cameroon

November 11, 2019 - 16:24 -- Open Access
Author(s): 
Amelie D. Mbouna, Adrian M. Tompkins, Andre Lenouo, Ernest O. Asare, Edmund I. Yamba and Clement Tchawoua
Reference: 
Malaria Journal 2019 18:359, 10 November 2019

A major health burden in Cameroon is malaria, a disease that is sensitive to climate, environment and socio-economic conditions, but whose precise relationship with these drivers is still uncertain. An improved understanding of the relationship between the disease and its drivers, and the ability to represent these relationships in dynamic disease models, would allow such models to contribute to health mitigation and adaptation planning. 

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Determinants of malaria treatment delay in northwestern zone of Tigray region, Northern Ethiopia, 2018

November 11, 2019 - 16:20 -- Open Access
Author(s): 
Afewerki Tesfahunegn, Dawit Zenebe and Alefech Addisu
Reference: 
Malaria Journal 2019 18:358, 9 November 2019

Globally malaria affects 212 million people and causes 438,000 deaths each year. Ensuring early and timely treatment of malaria is important for preventing and controlling of life-threatening complications and further transmission. 

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Utilization of key preventive measures for pregnancy complications and malaria among women in Jimma Zone, Ethiopia

November 8, 2019 - 16:57 -- Open Access
Author(s): 
Mariame Ouedraogo, Jaameeta Kurji, Lakew Abebe, Ronald Labonté, Sudhakar Morankar, Kunuz Haji Bedru, Gebeyehu Bulcha, Muluemebet Abera, Beth K. Potter, Marie-Hélène Roy-Gagnon & Manisha A. Kulkarni
Reference: 
BMC Public Health volume 19, Article number: 1443 (2019)

In Ethiopia, malaria infections and other complications during pregnancy contribute to the high burden of maternal morbidity and mortality. Preventive measures are available, however little is known about the factors influencing the uptake of maternal health services and interventions by pregnant women in Ethiopia.

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Occurrence and seasonal variation of human Plasmodium infection in Punjab Province, Pakistan

November 8, 2019 - 16:47 -- Open Access
Author(s): 
Naveeda Akhtar Qureshi, Huma Fatima, Muhammad Afzal, Aamir Ali Khattak & Muhammad Ali Nawaz
Reference: 
BMC Infectious Diseases 19, Article number: 935 (2019)

Malaria is the fifth leading cause of death worldwide. Pakistan is considered as a moderate malaria-endemic country but still, 177 million individuals are at risk of malaria. Roughly 60% of Pakistan’s population, live in malaria-endemic regions. The present study is based upon the survey of various health care centers in 10 major cities of Northern and Southern Punjab to find out the malarial infection patterns in 2015. The diagnosis, seasonal variations, age and gender-wise distribution of Plasmodium spp. circulating in the study area were also included in the objectives.

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