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Thailand

A Comparison of Two Short-Course Primaquine Regimens for the Treatment and Radical Cure of Plasmodium vivax Malaria in Thailand

April 13, 2010 - 08:40 -- Patrick Sampao
Author(s): 
Sasithon Pukrittayakamee, Mallika Imwong, Kesinee Chotivanich, Pratap Singhasivanon, Nicholas P. J. Day, AND Nicholas J. White
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 542-547

These data suggest that the dose-response relationships for primaquine's asexual stage and hypnozoitocidal activities in-vivo are different.

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Reviews: Artemisinin resistance: current status and scenarios for containment

March 18, 2010 - 13:31 -- Patrick Sampao
Author(s): 
Arjen M. Dondorp, Shunmay Yeung, Lisa White, Chea Nguon, Nicholas P.J. Day, Duong Socheat, Lorenz von Seidlein
Reference: 
Nature Reviews Microbiology 8 March 2010

Artemisinin combination therapies are the first-line treatments for uncomplicated Plasmodium falciparum malaria in most malaria-endemic countries. Recently, partial artemisinin-resistant P. falciparum malaria has emerged on the Cambodia–Thailand border.

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Open Access | Long-Lived Antibody and B Cell Memory Responses to the Human Malaria Parasites, Plasmodium falciparum and Plasmodium vivax

February 27, 2010 - 09:29 -- Ingeborg van Schayk
Author(s): 
Jiraprapa Wipasa, Chaisuree Suphavilai, Lucy C. Okell, Jackie Cook, Patrick H. Corran, Kanitta Thaikla, Witaya Liewsaree, Eleanor M. Riley, Julius Clemence R. Hafalla
Reference: 
PLoS Pathog 6(2): e1000770

In this study, we analysed the longevity of both antibody and B cell memory responses to malaria antigens among individuals who were living in an area of extremely low malaria transmission in northern Thailand, and who were known either to be malaria naïve or to have had a documented clinical attack of P. falciparum and/or P. vivax in the past 6 years.

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Open Access | Compliance with a three-day course of artesunate-mefloquine combination and baseline anti-malarial treatment in an area of Thailand with highly multidrug resistant falciparum malaria

February 10, 2010 - 10:33 -- Ingeborg van Schayk
Author(s): 
Kanungnit Congpuong, Pongwit Bualombai, Vick Banmairuroi, Kesara Na-Bangchang
Reference: 
Malaria Journal 2010, 9:43 (4 February 2010)

The authors discuss the compliance associated with a three-day AS-MQ regimen following a recent change in the treatment guidelines for uncomplicated falciparum malaria in Thailand. The patient data are supported by whole blood/plasma drug levels. In malaria treatment compliance remains a major factor determining effectiveness.

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Open Access | The interaction of seasonal forcing and immunity and the resonance dynamics of malaria

January 10, 2010 - 15:04 -- Ingeborg van Schayk
Author(s): 
Dylan Z. Childs and Michael Boots
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J R Soc Interface. 2010; 7:309-319.

We discuss the implications of our results for understanding prevalence patterns in long-term malaria datasets from Kenya that show multi-annual cycles and one from Thailand that does not and discuss the possible implications of treatment.

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Nucleotide sequence polymorphism at the apical membrane antigen-1 locus reveals population history of Plasmodium vivax in Thailand

November 26, 2009 - 06:55 -- Patrick Sampao
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Author(s): 
Chaturong Putaporntip, Somchai Jongwutiwes, Priscila Grynberg, Liwang Cui, Austin L. Hughes.
Reference: 
Infection, Genetics and Evolution, Volume 9, Issue 6, December 2009, Pages 1295-1300, doi:10.1016/j.meegid.2009.07.005.

Apical membrane antigen-1 is a candidate for inclusion in a vaccine for the human malaria parasite Plasmodium vivax.

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Short communication: IFNGR1 polymorphisms in Thai malaria patients

November 26, 2009 - 06:50 -- Patrick Sampao
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Author(s): 
Izumi Naka, Jintana Patarapotikul, Hathairad Hananantachai, Katsushi Tokunaga, Naoyuki Tsuchiya, Jun Ohashi
Reference: 
Infection, Genetics and Evolution, Volume 9, Issue 6, December 2009, Pages 1406-1409, doi:10.1016/j.meegid.2009.08.004

Interferon-γ (IFN-γ) has been suggested to play an important role in the pathogenesis of malaria.

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Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria

October 25, 2009 - 13:57 -- Bart G.J. Knols
Tags: 
Author(s): 
Izumi Naka et al.
Reference: 
Malaria Journal 2009, 8:232 (19 October 2009)

A haplotype block in which a primary polymorphism associated with severe malaria is likely to be encoded was identified in Thai malaria patients.

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