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Thailand

Effect of artesunate and mefloquine in combination on the Fridericia corrected QT intervals in Plasmodium falciparum infected adults from Thailand

March 17, 2011 - 08:49 -- Kabogo Ndegwa
Author(s): 
S. Krudsood, S. Looareesuwan, P. Wilairatama, W. Leowattana, N. Tangpukdee, K. Chalermrut, S. Ramanathan, V. Navaratnam, P. Olliaro, M. Vaillant, J. R. Kiechel and W. R. J. Taylor
Reference: 
Tropical Medicine & International Health, Volume 16, Issue 4, pages 458–465, April 2011

In this small group of patients, slowing heart rates due to malaria resolution best explained the observed increases in the QTcF intervals.

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Open Access | Short-Lived IFN-γ Effector Responses, but Long-Lived IL-10 Memory Responses, to Malaria in an Area of Low Malaria Endemicity

February 15, 2011 - 08:58 -- Kabogo Ndegwa
Author(s): 
Jiraprapa Wipasa, Lucy Okell, Supachai Sakkhachornphop, Chaisuree Suphavilai, Kriangkrai Chawansuntati, Witaya Liewsaree, Julius C. R. Hafalla, Eleanor M. Riley
Reference: 
PLoS Pathog 7(2): e1001281

Immunity to malaria is widely believed to wane in the absence of reinfection, but direct evidence for the presence or absence of durable immunological memory to malaria is limited.

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Tracking Origins and Spread of Sulfadoxine-Resistant Plasmodium falciparum dhps Alleles in Thailand

December 28, 2010 - 10:02 -- Kabogo Ndegwa
Author(s): 
Md Tauqeer Alam, Sumiti Vinayak, Kanungnit Congpuong, Chansuda Wongsrichanalai, Wichai Satimai, Laurence Slutsker, Ananias A. Escalante, John W. Barnwell, and Venkatachalam Udhayakumar
Reference: 
Antimicrobial Agents and Chemotherapy, January 2011, p. 155-164, Vol. 55, No. 1

The emergence and spread of drug-resistant Plasmodium falciparum have been a major impediment for the control of malaria worldwide.

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Mitochondrial DNA variation in the malaria vector Anopheles minimus across China, Thailand and Vietnam: evolutionary hypothesis, population structure and population history

December 16, 2010 - 08:57 -- Patrick Sampao
Author(s): 
B Chen, P M Pedro, R E Harbach, P Somboon, C Walton and R K Butlin
Reference: 
Heredity , (2 June 2010)

We compare alternative hypotheses concerning the origin of this pattern. The observed data deviate from the expectations based on a single-panmictic population with or without growth, or a stable but spatially structured population.

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Comparative Diagnosis of Malaria Infections by Microscopy, Nested PCR, and LAMP in Northern Thailand

July 2, 2010 - 12:54 -- Patrick Sampao
Author(s): 
Birgit Pöschl, Jarurin Waneesorn, Oriel Thekisoe, Salakchit Chutipongvivate, AND Karanis Panagiotis
Reference: 
Am J Trop Med Hyg, Jul 2010; 83: 56 - 60.

This study further validates LAMP as an alternative molecular diagnostic tool, which can be used in the diagnosis of early infections of malaria cases and together with nPCR can also be used as supplementary methods for clinical and epidemiological use.

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Open Access | Heritability of the Human Infectious Reservoir of Malaria Parasites

July 2, 2010 - 11:11 -- Kabogo Ndegwa
Author(s): 
Yaye Ramatoulaye Lawaly, Anavaj Sakuntabhai, Rick Paul, et al
Reference: 
PLoS ONE 5(6): e11358

The existence of a significant human genetic contribution to gametocyte prevalence in asymptomatic infections suggests that candidate gene and genome wide association approaches may be usefully applied to explore the underlying human genetics.

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CLOSED: EID 2010 - Thailand Conference on Emerging Infectious and Neglected Diseases

May 23, 2010 - 05:52 -- MalariaWorld Events

On behalf of the conference organizing committee, it is our great pleasure to welcome you to the Thailand Conference on Emerging Infectious and Neglected Diseases, organized by the National Science and Technology Development Agency (NSTDA) and many allied organizations in Thailand.

Mechanisms of Resistance: Increased Tolerance to Artemisinin in Plasmodium falciparum Is Mediated by a Quiescence Mechanism

April 20, 2010 - 09:07 -- Kabogo Ndegwa
Author(s): 
Benoit Witkowski, Joel Lelièvre, María José López Barragán, Victor Laurent, Xin-zhuan Su, Antoine Berry, and Françoise Benoit-Vical
Reference: 
Antimicrobial Agents and Chemotherapy, May 2010, p. 1872-1877, Vol. 54, No. 5

Artemisinin (ART)-based combination therapies (ACTs) are the first-line drugs—and often the last treatments—that can effectively cure Plasmodium falciparum infections. Unfortunately, the decreased clinical efficacy of artesunate, one of the major ART derivatives, was recently reported along the Thailand-Cambodia border.

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Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults

April 15, 2010 - 15:07 -- Patrick Sampao
Author(s): 
Chintana P., Collins O., et al.
Reference: 
Immunogenetics, Online first

Since the role of genetic variation in conditioning severe malaria in Thai adults is largely unexplored, the functional association between IL12B polymorphisms [i.e. IL12Bpro (rs17860508) and IL12B 3′ UTR T/G (rs3212227)], severe malaria and cytokine production was examined in patients with Plasmodium falciparum infections (n = 355) recruited from malaria endemic areas along the Thai–Myanmar border in northwest Thailand.

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Brief report: Emergence of New Alleles of the MSP-3{alpha} Gene in Plasmodium vivax Isolates from Korea

April 13, 2010 - 08:51 -- Patrick Sampao
Author(s): 
Deok Hwa N., Jun Seo O., et al.
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 522-524

Two new variants with similar size to SKOR-67 were first observed in 2002 and in 2006–2007 accounted for nearly 50% (25/51) of the sampled isolates.

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