These data suggest that falciparum malaria patients who develop clinical immunity (asymptomatic parasitaemia) in a low transmission setting such as the Peruvian Amazon have antibody responses to defined P. falciparum invasion ligand proteins higher than those found in symptomatic (non-immune) patients.
These data provide a better understanding of the taxonomy, population density, and seasonal and habitat distribution of potential malaria vectors within the Amazon Basin region.
Contrary to conventional low transmission models, this study provides evidence of a parasite population structure that is superficially defined by a clonal backbone.
In Peru, the P. vivax recurrent infections were common and displayed a high turnover of parasite genotypes compared to day 0.
Compared to Pf-naive controls, atypical memory B cells were increased in Peruvian adults exposed to low Pf transmission, and further increased in Malian adults exposed to intense Pf transmission.
The results give scientific validation to the traditional medical knowledge of the Amerindian and Mestizo populations from Loreto and exhibit a source of potentially active plants.
Despite being free of charge, treatment adherence to 7-day primaquine for the radical cure of Plasmodium vivax was estimated at 62.2% among patients along the Iquitos-Nauta road in the Peruvian Amazon.
Plasmodium vivax population structure was determined by multilocus genotyping with 16 microsatellites on 159 P. vivax infected blood samples (mono-infections) collected in four sites around Iquitos city.
The association between fish pond density and malaria suggests that fish ponds contribute to malaria transmission in the region. These results have important implications for the prevention and control of malaria and the development of pisciculture as an important economic activity in Amazonia and beyond.
No abstract available