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Cambodia

NOT Open Access | Decreasing pfmdr1 Copy Number Suggests that Plasmodium falciparum in Western Cambodia Is Regaining In Vitro Susceptibility to Mefloquine

April 14, 2015 - 17:36 -- NOT Open Access
Author(s): 
Pharath Lim, Dalin Dek, Vorleak Try, Sokunthea Sreng, Seila Suon, and Rick M. Fairhurst
Reference: 
Antimicrob. Agents Chemother. May 2015 vol. 59 no. 5 2934-2937

Dihydroartemisinin-piperaquine is the current frontline artemisinin combination therapy (ACT) for Plasmodium falciparum malaria in Cambodia but is now failing in several western provinces.

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Spatial clustering and risk factors of malaria infections in Ratanakiri Province, Cambodia

November 4, 2014 - 05:54 -- Open Access
Author(s): 
Vincent Sluydts, Somony Heng, Lies Durnez, et al.
Reference: 
Malaria Journal 2014, 13:387 (30 September 2014)

Spatial aggregation of malaria parasite carriers, and the identification of malaria species-specific risk factors provide key insights in malaria epidemiology in low transmission settings, which can guide targeted supplementary interventions.

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Spatial and temporal epidemiology of clinical malaria in Cambodia 2004-2013

October 29, 2014 - 13:33 -- Open Access
Author(s): 
Richard J Maude, Chea Nguon, Po Ly, Tol Bunkea, Pengby Ngor, Sara E Canavati de la Torre, Nicholas J White, Arjen M Dondorp, Nicholas PJ Day, Lisa J White, Char Meng Chuor
Reference: 
Malaria Journal 2014, 13:385 (30 September 2014)

The clinical burden of falciparum malaria in most areas of Cambodia has greatly decreased from 2009 to 2013, associated with roll-out of ITNs and VMWs.

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Medical Treatment: 

Novel approaches to risk stratification to support malaria elimination: an example from Cambodia

September 25, 2014 - 12:17 -- Open Access
Author(s): 
Cox J, Sovannaroth S, Dy Soley L, Ngor P, Mellor S, Roca-Feltrer A
Reference: 
Malaria Journal 2014, 13 :371 (19 September 2014)

This paper explores the utility of routine malaria surveillance data for the stratification of malaria risk in Cambodia, where the target is malaria elimination by 2025.

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NOT Open Access | Randomized, Double-Blind, Placebo-Controlled Clinical Trial of a Two-Day Regimen of Dihydroartemisinin-Piperaquine for Malaria Prevention Halted for Concern over Prolonged Corrected QT Interval

September 19, 2014 - 06:05 -- NOT Open Access
Author(s): 
Jessica Manning, Pattaraporn Vanachayangkul, David Saunders, et al.
Reference: 
Antimicrob. Agents Chemother. October 2014 vol. 58 no. 10 6056-6067

Dihydroartemisinin-piperaquine, the current first-line drug for uncomplicated malaria caused by Plasmodium falciparum and Plasmodium vivax in Cambodia, was previously shown to be of benefit as malaria chemoprophylaxis when administered as a monthly 3-day regimen.

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Evaluation of community-based systems for the surveillance of day three-positive Plasmodium falciparum cases in Western Cambodia

July 30, 2014 - 14:07 -- Open Access
Author(s): 
Cox J, Dy Soley L, Bunkea T, Sovannaroth S, Soy Ty K, Ngak S, Bjorge S, Ringwald P, Mellor S, Sintasath D, Meek S
Reference: 
Malaria Journal 2014, 13 :282 (22 July 2014)

Community-based surveillance of day-3 P. falciparum cases is feasible, but highly intensive, and as such needs strong and continuous support, particularly supervision and training.

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Not Open Access | Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies

November 20, 2013 - 17:15 -- NOT Open Access
Author(s): 
Benoit Witkowski, Chanaki Amaratunga, Didier Menard, et al.
Reference: 
The Lancet Infectious Diseases, Volume 13, Issue 12, December 2013, Pages 1043-1049
MalariaWorld

We aimed to assess whether an in-vitro ring-stage survival assay (RSA) can identify culture-adapted P falciparum isolates from patients with slow-clearing or fast-clearing infections, to investigate the stage-dependent susceptibility of parasites to dihydroartemisinin in the in-vitro RSA, and to assess whether an ex-vivo RSA can identify artemisinin-resistant P falciparum infections.

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Evaluation of parasite subpopulations and genetic diversity of the msp1, msp2 and glurp genes during and following artesunate monotherapy treatment of Plasmodium falciparum malaria in Western Cambodia

November 14, 2013 - 07:54 -- Open Access
Author(s): 
Gosi P, Lanteri CA, Bethell D, et al.
Reference: 
Malaria Journal 2013, 12 :403 (9 November 2013)
MalariaWorld

The parasites responsible for artemisinin-resistant malaria in a clinical trial in Western Cambodia comprise the dominant clones of acute malaria infections rather than minority clones emerging during treatment.

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Outdoor malaria transmission in forested villages of Cambodia

September 19, 2013 - 14:43 -- Open Access
Tags: 
Author(s): 
Durnez L, Mao S, Denis L, Roelants P, Sochantha T, Coosemans M
Reference: 
Malaria Journal 2013, 12 :329 (17 September 2013)
MalariaWorld

In Cambodia, outdoor malaria transmission in villages and forest plots is important.

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Direct comparison of the histidine-rich protein-2 enzyme-linked immunosorbent assay (HRP-2 ELISA) and malaria SYBR green I fluorescence (MSF) drug sensitivity tests in Plasmodium falciparum reference clones and fresh ex vivo field isolates from Cambodia

July 16, 2013 - 16:02 -- Open Access
Author(s): 
Chaorattanakawee S, Tyner SD, Lon C, Yingyuen K, Ruttvisutinunt W, Sundrakes S, Sai-gnam P, Johnson JD, Walsh DS, Saunders DL, Lanteri CA
Reference: 
Malaria Journal 2013, 12:239 (12 July 2013)
MalariaWorld

The objective was to determine which of these two common assays is more appropriate for studying drug susceptibility of "immediate ex vivo" (IEV) isolates, analysed without culture adaption, in a region of relatively low malaria transmission.

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