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Cambodia

Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: retrospective and prospective investigations

January 5, 2016 - 15:13 -- Open Access
Author(s): 
Duru V, Khim N, Menard D, et al.
Reference: 
BMC Medicine 2015, 13 :305 (22 December 2015)

The prospective study assessed ex vivo PSA survival rate alongside K13 polymorphism of isolates collected from patients enrolled in an open-label study with dihydroartemisinin-piperaquine for uncomplicated P. falciparum malaria in Cambodia (registered ACTRN12615000696594).

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Assuring access to topical mosquito repellents within an intensive distribution scheme: a case study in a remote province of Cambodia

November 24, 2015 - 15:27 -- Open Access
Author(s): 
Somony Heng, Lies Durnez, Vincent Sluydts, et al.
Reference: 
Malaria Journal 2015, 14:468 (24 November 2015)

After the existing public health system was reinforced with programmatic and logistic support, an intense 2-weekly distribution scheme of a vector control tool over a 2-year period was operated successfully in the field.

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Not Open Access | Using Amplicon Deep Sequencing to Detect Genetic Signatures of Plasmodium vivax Relapse

August 26, 2015 - 16:58 -- NOT Open Access
Author(s): 
Jessica T. Lin, Nicholas J. Hathaway, Jonathan J. Juliano, et al.
Reference: 
The Journal of Infectious Diseases Volume 212, Issue 6Pp. 999-1008

We applied amplicon deep sequencing to P. vivax isolates from 78 Cambodian volunteers, nearly one-third of whom suffered recurrence at a median of 68 days. Deep sequencing at a highly variable region of the P. vivax merozoite surface protein 1 gene revealed impressive diversity—generating 67 unique haplotypes and detecting on average 3.6 cocirculating parasite clones within individuals, compared to 2.1 clones detected by a combination of 3 microsatellite markers. 

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Elimination of Plasmodium falciparum in an area of multi-drug resistance

August 17, 2015 - 08:29 -- Open Access
Author(s): 
Khin Lwin, Mallika Imwong, Preyanan Suangkanarat, Atthanee Jeeyapant, Benchawan Vihokhern, Klanarong Wongsaen, Georges Snounou, Lilly Keereecharoen, Nicholas J White, Francois Nosten
Reference: 
Malaria Journal 2015, 14:319 (16 August 2015)

Mass drug administration with dihydroartemisinin-piperaquine may be an effective strategy to eliminate P. falciparum rapidly where multi-drug resistance is present.

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Malaria and the mobile and migrant population in Cambodia: a population movement framework to inform strategies for malaria control and elimination

June 20, 2015 - 11:37 -- Open Access
Tags: 
Author(s): 
Philippe Guyant, Sara E Canavati, Nguon Chea, Po Ly, Maxine Whittaker, Arantxa Roca-Feltrer, Shunmay Yeung
Reference: 
Malaria Journal 2015, 14:252 (20 June 2015)

This paper describes the process of defining MMPs in Cambodia, identifying the different activities and related risks to appropriately target and tailor interventions to the highest risk groups.

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Use of Plasmodium falciparum culture-adapted field isolates for in vitro exflagellation-blocking assay

June 4, 2015 - 08:24 -- Open Access
Author(s): 
Louis-Jérôme Leba, Lise Musset, Jean Popovici, et al.
Reference: 
Malaria Journal 2015, 14:234 (4 June 2015)

This work shows that in vitro culture-adapted P. falciparum field isolates of different genetic background, from South America and Southeast Asia, can successfully be used for bioassays targeting the male gametocyte to gamete transition, exflagellation.

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Determinants of price setting decisions on anti-malarial drugs at retail shops in Cambodia

June 2, 2015 - 08:28 -- Open Access
Tags: 
Author(s): 
Edith Patouillard, Kara Hanson, Immo Kleinschmidt, Benjamin Palafox, Sarah Tougher, Sochea Pok, Kate O¿Connell, Catherine Goodman
Reference: 
Malaria Journal 2015, 14:224 (30 May 2015)

The results indicate that provider pricing as well as other key elements of anti-malarial supply and demand may have played an important role in the limited access to appropriate malaria treatment in Cambodia.

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Imputation-Based Population Genetics Analysis of Plasmodium falciparum Malaria Parasites

May 4, 2015 - 10:40 -- Open Access
Author(s): 
Hanif Samad, Francesc Coll, Mark D. Preston, Harold Ocholla, Rick M. Fairhurst, Taane G. Clark
Reference: 
PLoS Genet 11(4): e1005131

Whole-genome sequencing technologies are being increasingly applied to Plasmodium falciparum clinical isolates to identify genetic determinants of malaria pathogenesis.

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Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

April 27, 2015 - 13:09 -- Open Access
Author(s): 
Con Dogovski, Stanley C. Xie, Leann Tilley, et al.
Reference: 
PLoS Biol 13(4): e1002132

Successful control of falciparum malaria depends greatly on treatment with artemisinin combination therapies.

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Re-imagining malaria: heterogeneity of human and mosquito behaviour in relation to residual malaria transmission in Cambodia

April 24, 2015 - 08:58 -- Open Access
Tags: 
Author(s): 
Charlotte Gryseels, Lies Durnez, Koen Peeters Grietens, et al.
Reference: 
Malaria Journal 2015, 14:165 (24 April 2015)

The heterogeneity of human behaviour and the variation of vector densities and biting behaviours may lead to a considerable proportion of exposure occurring during times that people are assumed to be protected by the distributed LLINs.

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