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Cambodia

Guest editorial: “End Malaria for Good”- a few key messages based on the Cambodian experience

June 23, 2016 - 07:27 -- Bart G.J. Knols
The editorial below was contributed by Sara E Canavati and Jack S Richards. Contact details below.
 
World Malaria Day (WMD) is an international observance established in 2007 and commemorated every year on 25 April to recognize global efforts to control malaria. The theme for 2016 was “End Malaria For Good”, which focused on malaria elimination. Following the great progress made under the Millennium Development Goals, it is important to continue building on this success as we transition into the Sustainable Development Goals [1] and the recently launched Global Technical Strategy for Malaria (GTS) [2]. The aim of the piece is to briefly reflect on WMD 2016 and consider a few key operational issues on malaria elimination that may lie ahead for the coming year.

NOT Open Access | Efficacy and Safety of Pyronaridine-Artesunate plus Single-Dose Primaquine for Treatment of Uncomplicated Plasmodium falciparum Malaria in Eastern Cambodia

March 6, 2019 - 13:21 -- NOT Open Access
Author(s): 
Rithea Leang, Melissa Mairet-Khedim, Huch Chea, Rekol Huy, Nimol Khim, Denis Mey Bouth, Maria Dorina Bustos, Pascal Ringwald and Benoit Witkowski
Reference: 
Antimicrob. Agents Chemother. February 2019 63:e02242-18

In Cambodia, multidrug-resistant Plasmodium falciparum undermines the treatment of uncomplicated malaria, and new therapeutic options are needed.

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NOT Open Access | Absence of a High Level of Duplication of the Plasmepsin II Gene in Africa

October 30, 2018 - 12:48 -- NOT Open Access
Author(s): 
Marie Gladys Robert, Francis Foguim Tsombeng, Bruno Pradines, et al.
Reference: 
Antimicrob. Agents Chemother. November 2018 62:e00374-18

Resistance to piperaquine has been associated with the amplification of the plasmepsin II gene in Cambodia.

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Diagnostic accuracy of loop-mediated isothermal amplification (LAMP) for screening malaria in peripheral and placental blood samples from pregnant women in Colombia

July 17, 2018 - 15:52 -- Open Access
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Author(s): 
Ana María Vásquez, Lina Zuluaga, Alberto Tobón, Maritza Posada, Gabriel Vélez, Iveth J. González, Ana Campillo and Xavier Ding
Reference: 
Malaria Journal 2018 17:262, 13 July 2018

LAMP is a simple, rapid and accurate molecular tool for detecting gestational and placental malaria, being able to overcome the limited sensitivity of LM and RDT.

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Comparison of glucose-6 phosphate dehydrogenase status by fluorescent spot test and rapid diagnostic test in Lao PDR and Cambodia

June 26, 2018 - 16:28 -- Open Access
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Author(s): 
Gisela Henriques, Koukeo Phommasone, Mayfong Mayxay, et al.
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Malaria Journal 2018 17:243, 22 June 2018

The interpretation of RDT results requires some training but is a good alternative to the FST.

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Genomic Analyses Reveal the Common Occurrence and Complexity of Plasmodium vivax Relapses in Cambodia

March 13, 2018 - 13:36 -- Open Access
Author(s): 
Jean Popovici, Lindsey R. Friedrich, David Serre, et al.
Reference: 
mBio vol. 9 no. 1 e01888-17, 23 January 2018

Plasmodium vivax parasites have a unique dormant stage that can cause relapses weeks or months after the initial infection.

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Community participation during two mass anti-malarial administrations in Cambodia: lessons from a joint workshop

January 29, 2018 - 15:45 -- Open Access
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Author(s): 
Thomas J. Peto, Mark Debackere, Jean-Marie Kindermans, et al.
Reference: 
Malaria Journal 2018 17:53, 27 January 2018

Two mass drug administrations (MDA) against falciparum malaria were conducted in 2015–16, one as operational research in northern Cambodia, and the other as a clinical trial in western Cambodia.

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Identification and characterization of areas of high and low risk for asymptomatic malaria infections at sub-village level in Ratanakiri, Cambodia

January 16, 2018 - 16:08 -- Open Access
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Author(s): 
Lies Durnez, Myrthe Pareyn, Vanna Mean, Saorin Kim, Nimol Khim, Didier Menard, Marc Coosemans, Tho Sochantha and Vincent Sluydts
Reference: 
Malaria Journal 2018 17:27, 15 January 2018

Clusters of malaria carriers were malaria species specific and often located remotely, outside village centres.

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Field assessment of a novel spatial repellent for malaria control: a feasibility and acceptability study in Mondulkiri, Cambodia

October 17, 2017 - 12:03 -- Open Access
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Author(s): 
Marco Liverani, Jacques Derek Charlwood, Harriet Lawford and Shunmay Yeung
Reference: 
Malaria Journal 2017 16:412, 13 October 2017

Widespread use of spatial repellents would not fill all protective gaps, but, if their entomological efficacy can be ascertained, outdoor application has the potential to enhance vector control strategies in Cambodia.

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Measuring ex vivo drug susceptibility in Plasmodium vivax isolates from Cambodia

October 3, 2017 - 17:30 -- Open Access
Author(s): 
Suwanna Chaorattanakawee, Chanthap Lon, David L. Saunders, et al.
Reference: 
Malaria Journal 2017 16:392, 30 September 2017

The findings of high P. vivax IC50 to mefloquine and piperaquine, but not chloroquine, suggest significant drug pressure from drugs used to treat multidrug resistant P. falciparum in Cambodia.

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