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Review: Global Phenotypic Screening for Antimalarials

February 21, 2012 - 13:39 -- Patrick Sampao
Author(s): 
W. Armand Guiguemde, Anang A. Shelat, Jose F. Garcia-Bustos, Thierry T. Diagana, Francisco-Javier Gamo, R. Kiplin Guy
Reference: 
Chemistry & Biology, Volume 19, Issue 1, 27 January 2012, Pages 116–129

MalariaWorldIn this review, we describe the characterization of these compounds, explore currently ongoing strategies to develop lead molecules, and endorse the concept of a “malaria box” of publicly accessible active compounds.

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Open Access | Modelling the global constraints of temperature on transmission of Plasmodium falciparum and P. vivax

June 1, 2011 - 07:10 -- Patrick Sampao
Author(s): 
Gething PW, Van Boeckel TP, Smith DL, Guerra CA, Patil AP, Snow RW, Hay SI
Reference: 
Parasites & Vectors 2011, 4:92 (26 May 2011)

We defined a dynamic biological model that incorporated the principal mechanisms of temperature dependency in the malaria transmission cycle and used it with fine spatial and temporal resolution temperature data to evaluate time-series of temperature suitability for transmission of Plasmodium falciparum and P. vivax throughout an average year, quantified using an index proportional to the basic reproductive number.

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