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Pakistan

Prevalence and patterns of antifolate and chloroquine drug resistance markers in Plasmodium vivax across Pakistan

September 9, 2013 - 16:07 -- Open Access
Author(s): 
Khattak AA, Venkatesan M, Khatoon L, Ouattara A, Kenefic LJ, Nadeem MF, Nighat F, Malik SA, Plowe CV
Reference: 
Malaria Journal 2013, 12:310 (5 September 2013)
MalariaWorld

The aims of this study were to determine the prevalence of polymorphisms in the SP resistance-associated genes pvdhfr, pvdhps and chloroquine resistance-associated gene pvmdr1 in P. vivax isolates collected from across the country.

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A comprehensive survey of polymorphisms conferring anti-malarial resistance in Plasmodium falciparum across Pakistan

September 4, 2013 - 11:25 -- Open Access
Author(s): 
Khattak AA, Venkatesan M, Jacob CG, Artimovich EM, Nadeem MF, Nighat F, Hombhanje F, Mita T, Malik SA, Plowe CV
Reference: 
Malaria Journal 2013, 12:300 (29 August 2013)
MalariaWorld

These results suggest an emerging problem with multidrug resistant P. falciparum in Pakistan.

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Prevalence and distribution of human Plasmodium infection in Pakistan

August 29, 2013 - 11:46 -- Open Access
Author(s): 
Khattak AA, Venkatesan M, Nadeem MF, Satti HS, Yaqoob A, Strauss K, Khatoon L, Malik SA, Plowe CV
Reference: 
Malaria Journal 2013, 12:297 (28 August 2013)
MalariaWorld

Plasmodium infections in Pakistan are largely attributed to P. vivax but P. falciparum and mixed species infections are also prevalent.

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Prevalence of drug resistance associated mutations in Plasmodium vivax against sulphadoxine-pyrimethamine in southern Pakistan

August 12, 2013 - 09:51 -- Open Access
Author(s): 
Raza A, Ghanchi NK, Khan MS, Beg MA
Reference: 
Malaria Journal 2013, 12:261 (26 July 2013)
MalariaWorld

This is the first report from southern Pakistan on SP resistance in clinical isolates of P. vivax. Results from this study confirm that diverse drug resistant alleles are circulating within this region.

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Reducing transfusion-associated malaria in Pakistan: an algorithmic approach

July 17, 2013 - 12:49 -- Open Access
Tags: 
Author(s): 
Zain A Sobani, Sobia Nizami, Mehnaz Jabeen, Nayla Ahmed, Najia Karim Ghanchi, Mohammad Wasay, Bushra Moiz, and Mohammed Asim Beg
Reference: 
Trop Doct July 2013 vol. 43 no. 3 124-127
MalariaWorld

Blood transfusions represent a small but significant source of malaria transmission.

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Genetic diversity of Plasmodium vivax clinical isolates from southern Pakistan using pvcsp and pvmsp1 genetic markers

January 15, 2013 - 14:25 -- Open Access
Author(s): 
Raza A, Ghanchi NK, Thaver AM, Jafri S, Beg MA
Reference: 
Malaria Journal 2013, 12:16 (11 January 2013)
MalariaWorld

This is the first report from southern Pakistan on characterization of P. vivax isolates confirming that extensively diverse pvcsp and pvmsp1 variants are present within this region.

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Genetic backgrounds of the Plasmodium falciparum chloroquine resistant transporter (pfcrt) alleles in Pakistan

March 5, 2012 - 12:14 -- Patrick Sampao
Author(s): 
Wasiq Faraz Rawasia, Sankar Sridaran, Mohammad Asim Beg, et al.
Reference: 
Infection, Genetics and Evolution, Volume 12, Issue 2, March 2012, Pages 278-281

MalariaWorldThis study was undertaken to investigate the genetic background of the CQ resistant pfcrt haplotypes in Pakistan.

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Open Access | Clinical trial of extended-dose chloroquine for treatment of resistant falciparum malaria among Afghan refugees in Pakistan

June 28, 2011 - 06:43 -- Kabogo Ndegwa
Author(s): 
Howard N, Durrani N, Sanda S, Beshir K, Hallett R, Rowland M
Reference: 
Malaria Journal 2011, 10:171 (23 June 2011)

CQ is not suitable for first-line falciparum treatment in Afghan refugee communities.

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Open Access | District level external quality assurance (EQA) of malaria microscopy in Pakistan: pilot implementation and feasibility

February 23, 2011 - 09:48 -- Kabogo Ndegwa
Author(s): 
Khan M
Reference: 
Malaria Journal 2011, 10:45 (17 February 2011)

A district-based EQA, based on lot quality assurance methods was implemented, using context-specific operational guidelines, tools and training modules, and other inputs from the malaria control programme and partners.

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Open Access | Prevalence of resistance associated polymorphisms in Plasmodium falciparum field isolates from southern Pakistan

February 2, 2011 - 08:23 -- Kabogo Ndegwa
Author(s): 
Ghanchi NK, Ursing J, Beg MA, Veiga MI, Jafri S, Martensson A
Reference: 
Malaria Journal 2011, 10:18 (28 January 2011)

The results indicate high prevalence of in vivo resistance to chloroquine, whereas high grade resistance to sulphadoxine-pyrimethamine does not appear to be widespread among P. falciparum in southern Pakistan.

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