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Malawi

Open Access | Comparative population structure of Plasmodium malariae and Plasmodium falciparum under different transmission settings in Malawi

February 15, 2011 - 09:37 -- Kabogo Ndegwa
Author(s): 
Bruce MC, Macheso A, McConnachie A, Molyneux ME
Reference: 
Malaria Journal 2011, 10:38 (11 February 2011)

The extent of similarity between P. falciparum and P. malariae population structure described by the high level of multiple infection, the lack of significant population differentiation or haplotype clustering and lack of linkage disequilibrium is surprising given the differences in the biological features of these species that suggest a reduced potential for out-crossing and transmission in P. malariae.

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Population Pharmacokinetics of Sulfadoxine and Pyrimethamine in Malawian Children With Malaria

January 25, 2011 - 09:21 -- Kabogo Ndegwa
Author(s): 
D J Bell, S K Nyirongo, M Mukaka, M E Molyneux, P A Winstanley and S A Ward
Reference: 
Clinical Pharmacology & Therapeutics (2011) 89 2, 268–275

In addition to parasite resistance, inadequate levels of exposure to antimalarial drugs may contribute to treatment failure.

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Open Access | Pyrethroid resistance in southern African Anopheles funestus extends to Likoma Island in Lake Malawi

January 3, 2011 - 14:29 -- Patrick Sampao
Author(s): 
Hunt RH, Edwardes M, Coetzee M
Reference: 
Parasites & Vectors 2010, 3:122 (31 December 2010)

A mosquito survey was carried out on the island of Likoma in Lake Malawi with a view to collecting baseline data to determine the feasibility of implementing an integrated malaria vector control programme.

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Effect of Repeated Treatment of Pregnant Women with Sulfadoxine-Pyrimethamine and Azithromycin on Preterm Delivery in Malawi: A Randomized Controlled Trial

December 3, 2010 - 07:55 -- Patrick Sampao
Author(s): 
Mari Luntamo, Teija Kulmala, Bernard Mbewe, Yin Bun Cheung, Kenneth Maleta, AND Per Ashorn
Reference: 
Am J Trop Med Hyg, Dec 2010; 83: 1212 - 1220.

We enrolled 1,320 pregnant women into a randomized, controlled trial in Malawi to study whether preterm delivery and low birth weight (LBW) incidence can be reduced by intermittent preventive treatment of maternal malaria and reproductive tract infections.

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Open Access | Comparison of real-time PCR and microscopy for malaria parasite detection in Malawian pregnant women

October 11, 2010 - 08:10 -- Kabogo Ndegwa
Author(s): 
Rantala A, Taylor SM, Trottman PA, Luntamo M, Mbewe B, Maleta K, Kulmala T, Ashorn P, Meshnick SR
Reference: 
Malaria Journal 2010, 9:269 (6 October 2010)

Although microscopy remains the most appropriate method for clinical malaria diagnosis in field settings, molecular diagnostics such as real-time PCR offer a more reliable means to detect malaria parasites, particularly at low levels.

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Open Access | Comparative field performance and adherence to test results of four malaria rapid diagnostic tests among febrile patients more than five years of age in Blantyre, Malawi

July 21, 2010 - 12:24 -- Kabogo Ndegwa
Author(s): 
Chinkhumba J, Skarbinski J, Chilima B, Campbell C, Ewing V, San Joaquin M, Sande J, Ali D, Mathanga D
Reference: 
Malaria Journal 2010, 9:209 (20 July 2010)

The results of this evaluation, combined with other published data and global recommendations, have been used to select RDTs for national scale-up. In addition, the study identified some key issues that need to be further delineated: the low field specificity of RDTs, variable RDT performance by different cadres of health workers and the need for a robust quality assurance system.

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Open Access | The Platelet Count in Cerebral Malaria, Is It Useful to the Clinician?

July 2, 2010 - 10:19 -- Patrick Sampao
Author(s): 
Yamikani Chimalizeni, Kondwani Kawaza, Terrie Taylor, and Malcolm Molyneux
Reference: 
Am. J. Trop. Med. Hyg., 83(1), 2010, pp. 48-50

We studied children with cerebral malaria admitted to the pediatric research ward at Queen Elizabeth Central Hospital, Malawi. We analyzed 1,811 children with cerebral malaria and compared them with 521 children with bacterial meningitis.

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Clinical Picture: Malarial retinopathy and fluorescein angiography findings in a Malawian child with cerebral malaria

May 25, 2010 - 13:18 -- Patrick Sampao
Author(s): 
Simon J Glover, Richard J Maude, Terrie E Taylor, Malcolm E Molyneux, Nicholas AV Beare
Reference: 
The Lancet Infectious Diseases, Volume 10, Issue 6, June 2010, Page 440

No abstract available

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The effect of timing and frequency of Plasmodium falciparum infection during pregnancy on the risk of low birth weight and maternal anemia

May 11, 2010 - 13:35 -- Patrick Sampao
Author(s): 
Linda Kalilani, Innocent Mofolo, Marjorie Chaponda, Stephen J. Rogerson, Steven R. Meshnick
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 6, June 2010, Pages 416-422

Birth weight and maternal hemoglobin were measured at delivery. The association between timing and frequency of infection and LBW and maternal anemia was analyzed using a binomial regression model.

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Open Access | Comparison of anaemia and parasitaemia as indicators of malaria control in household and EPI-health facility surveys in Malawi

April 22, 2010 - 13:24 -- Kabogo Ndegwa
Author(s): 
Mathanga DP, Campbell CH, Vanden Eng J, Wolkon A, Bronzan RN, Malenga GJ, Ali D, Desai M
Reference: 
Malaria Journal 2010, 9:107 (21 April 2010)

Increasing access to effective malaria prevention was associated with a reduced burden of malaria in young Malawian children. Anaemia measured at the HF level at time of routine vaccination may be a good surrogate indicator for its measurement at the HH level in evaluating national malaria control programmes.

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