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Malawi

Integrated paediatric fever management and antibiotic over-treatment in Malawi health facilities: data mining a national facility census

August 8, 2016 - 10:43 -- Open Access
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Author(s): 
Emily White Johansson, Katarina Ekholm Selling, Humphreys Nsona, Bonnie Mappin, Peter W. Gething, Max Petzold, Stefan Swartling Peterson and Helena Hildenwall
Reference: 
Malaria Journal 2016 15:396, 4 August 2016

Integrated paediatric fever management was sub-optimal for completed assessments and antibiotic targeting despite common compliance to malaria treatment guidelines.

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Adherence to national guidelines for the diagnosis and management of severe malaria: a nationwide, cross-sectional survey in Malawi, 2012

July 23, 2016 - 17:06 -- Open Access
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Author(s): 
Monica P. Shah, Melissa Briggs-Hagen, Kim A. Lindblade, et al.
Reference: 
Malaria Journal 2016 15:369, 19 July 2016

A majority of patients diagnosed with severe malaria received the recommended IV therapy in accordance with national treatment guidelines.

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Delayed acquisition of Plasmodium falciparum antigen-specific CD4+ T cell responses in HIV-exposed uninfected Malawian children receiving daily cotrimoxazole prophylaxis

May 16, 2016 - 17:34 -- Open Access
Author(s): 
Herbert Longwe, Kamija S. Phiri, Nyanyiwe M. Mbeye, Thandile Gondwe, Wilson L. Mandala and Kondwani C. Jambo
Reference: 
Malaria Journal 2016 15:264

The results demonstrate that there is delayed acquisition of P. falciparum-specific IFN-γ-producing CD4+ T cells in HEU children on daily cotrimoxazole prophylaxis, which is evident at 6 and 12 months of age in comparison to HUU age-matched controls.

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Use of thin-layer chromatography to detect counterfeit sulfadoxine/pyrimethamine tablets with the wrong active ingredient in Malawi

April 15, 2016 - 15:15 -- Open Access
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Author(s): 
Felix Khuluza, Stephen Kigera, Richard W. O. Jähnke and Lutz Heide
Reference: 
Malaria Journal 2016 15:215, 14 April 2016

Due to the absence of the declared anti-malarial ingredients and due to the presence of other pharmaceutical ingredients, the identified falsified medicine represents a serious health risk for the population.

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Feasibility, acceptability and impact of integrating malaria rapid diagnostic tests and pre-referral rectal artesunate into the integrated community case management programme. A pilot study in Mchinji district, Malawi

March 22, 2016 - 17:37 -- Open Access
Author(s): 
Themba B. Phiri, Blessings N. Kaunda-Khangamwa, Andrew Bauleni, Tiyese Chimuna, David Melody, Humphreys Kalengamaliro, John H. Sande, Humphreys Kampira Nsona and Don P. Mathanga
Reference: 
Malaria Journal 2016 15:177, 21 March 2016

Integration of RDTs and pre-referral rectal at artesunate community level is both feasible and acceptable.

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Activated Neutrophils Are Associated with Pediatric Cerebral Malaria Vasculopathy in Malawian Children

March 9, 2016 - 09:16 -- Open Access
Author(s): 
Catherine Manix Feintuch, Alex Saidi, Johanna P. Daily, et al.
Reference: 
mBio vol. 7 no. 1 e01300-15

Most patients with cerebral malaria (CM) sustain cerebral microvascular sequestration of Plasmodium falciparum-infected red blood cells (iRBCs).

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The effectiveness of long-lasting, insecticide-treated nets in a setting of pyrethroid resistance: a case–control study among febrile children 6 to 59 months of age in Machinga District, Malawi

November 19, 2015 - 06:25 -- Open Access
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Author(s): 
Don Mathanga, Dyson Mwandama, Andy Bauleni, Joseph Chisaka, Monica Shah, Keren Landman, Kim Lindblade, Laura Steinhardt
Reference: 
Malaria Journal 2015, 14:457 (17 November 2015)

This study did not find a significant personal protective effect of ITNs.

Background

The escalating level of mosquito resistance to pyrethroid insecticides threatens the effectiveness of insecticide-treated nets (ITNs) for malaria control in Malawi. An evaluation of the effectiveness of ITNs for preventing malaria in children aged 6–59 months old, after 1 year of mass distribution of LLINs was conducted in Machinga District, Malawi, an area of moderate pyrethroid resistance.

Methods

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The prevalence of malaria at first antenatal visit in Blantyre, Malawi declined following a universal bed net campaign

November 4, 2015 - 11:52 -- Open Access
Author(s): 
Sarah Boudová, Titus Divala, Patricia Mawindo, Lauren Cohee, Linda Kalilani-Phiri, Phillip Thesing, Terrie Taylor, Miriam Laufer
Reference: 
Malaria Journal 2015, 14:422 (29 October 2015)

Malaria infection in pregnant women is common even after a bed net campaign in Malawi, though prevalence rates declined.

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The effect of local variation in malaria transmission on the prevalence of sulfadoxine–pyrimethamine resistant haplotypes and selective sweep characteristics in Malawi

October 12, 2015 - 16:49 -- Open Access
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Author(s): 
Elena Artimovich, Atupele Kapito-Tembo, Shannon Takala-Harrison, et al.
Reference: 
Malaria Journal 2015, 14:387 (5 October 2015)

The results do not show an effect of local variation in malaria transmission, as inferred from parasite prevalence, on SP-resistant haplotype prevalence.

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Rise of multiple insecticide resistance in Anopheles funestus in Malawi: a major concern for malaria vector control

September 21, 2015 - 17:28 -- Open Access
Author(s): 
Jacob Riveron, Martin Chiumia, Benjamin Menze, Kayla Barnes, Helen Irving, Sulaiman Ibrahim, Gareth Weedall, Themba Mzilahowa, Charles Wondji
Reference: 
Malaria Journal 2015, 14:344 (15 September 2015)

Such increased resistance levels and rise of multiple resistance highlight the need to rapidly implement resistance management strategies to preserve the effectiveness of existing insecticide-based control interventions.

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