Travel was the main factor influencing the incidence of malaria illness among residents of urban Blantyre compared with peri-urban areas.
SP resistance selection pressures have been retained in the Malawian population, with known resistance dhfr mutations at fixation, complemented by a novel gch1 promoter duplication.
Pyrethroid resistance was detected in An. funestus and An. arabiensis populations across Malawi and has worsened over the last 5 years.
Antibodies to placental-binding infected erythrocytes may be associated with higher haemoglobin levels in pregnancy, whereas antibodies to other malaria antigens may instead be markers of malaria exposure.
School-age children frequently carry gametocytes in communities of southern Malawi and represent an under-recognized reservoir of infection
This study illustrates the complex interplay between geographic access and gender dynamics in shaping decisions on whether and when formal treatment is sought for febrile children in Chikwawa District.
Overall, the study identified facilitating factors to malaria research utilization for policy development in Malawi.
Integrated paediatric fever management was sub-optimal for completed assessments and antibiotic targeting despite common compliance to malaria treatment guidelines.
A majority of patients diagnosed with severe malaria received the recommended IV therapy in accordance with national treatment guidelines.
The results demonstrate that there is delayed acquisition of P. falciparum-specific IFN-γ-producing CD4+ T cells in HEU children on daily cotrimoxazole prophylaxis, which is evident at 6 and 12 months of age in comparison to HUU age-matched controls.