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Malawi

Signatures of divergent anti-malarial treatment responses in peripheral blood from adults and young children in Malawi

June 24, 2019 - 15:58 -- Open Access
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Author(s): 
Paul L. Maurizio, Hubaida Fuseini, Gerald Tegha, Mina Hosseinipour and Kristina De Paris
Reference: 
Malaria Journal 2019 18:205, 24 June 2019

Heterogeneity in the immune response to parasite infection is mediated in part by differences in host genetics, gender, and age group. In infants and young children, ongoing immunological maturation often results in increased susceptibility to infection and variable responses to drug treatment, increasing the risk of complications. Even though significant age-associated effects on host cytokine responses to Plasmodium falciparum infection have been identified, age-associated effects on uncomplicated malaria infection and anti-malarial treatment remain poorly understood.

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Intermittent screening and treatment with dihydroartemisinin-piperaquine and intermittent preventive therapy with sulfadoxine-pyrimethamine have similar effects on malaria antibody in pregnant Malawian women

June 7, 2019 - 16:56 -- Open Access
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Author(s): 
Andrew Teo, Louise M. Randall, Stephen J. Rogerson, et al.
Reference: 
Scientific Reports 9, Article number: 7878 (2019)

In a randomised trial comparing intermittent screening and treatment (IST) with dihydroartemisinin-piperaquine (DP) and intermittent preventive therapy against malaria in pregnancy (IPT) with sulfadoxine-pyrimethamine (SP) in Malawi, the impacts of IST-DP and IPT-SP on the development and maintenance of malaria antibody immunity were compared.

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Assessment of the Suna trap for sampling mosquitoes indoors and outdoors

February 28, 2019 - 15:31 -- Open Access
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Author(s): 
Monicah M. Mburu, Kennedy Zembere, Alexandra Hiscox, Jomo Banda, Kamija S. Phiri, Henk van den Berg, Themba Mzilahowa, Willem Takken and Robert S. McCann
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Malaria Journal 2019 18:51, 22 February 2019

The efficiency of the Suna trap in sampling mosquitoes was equivalent to that of the HLC.

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The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children

January 22, 2019 - 14:51 -- Open Access
Author(s): 
Priyanka Barua, James G. Beeson, Kenneth Maleta, Per Ashorn and Stephen J. Rogerson
Reference: 
Malaria Journal 2019 18:11, 18 January 2019

Antibodies to merozoite and IE surface antigens increased following infection in early childhood, but neither age at first infection nor number of malaria episodes substantially affected antibody acquisition.

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The effect of mobile phone text message reminders on health workers’ adherence to case management guidelines for malaria and other diseases in Malawi: lessons from qualitative data from a cluster-randomized trial

January 2, 2019 - 15:31 -- Open Access
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Author(s): 
Blessings N. Kaunda-Khangamwa, Laura C. Steinhardt, Alexander K. Rowe, Austin Gumbo, Dubulao Moyo, Humphreys Nsona, Peter Troell, Dejan Zurovac and Don Mathanga
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Malaria Journal 2018 17:481, 19 December 2018

Text-message reminders to HWs can provide a platform to improve understanding of treatment guidelines and case management decision-making skills, but might not improve actual adherence to guidelines.

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Prevalence of inherited blood disorders and associations with malaria and anemia in Malawian children

November 21, 2018 - 15:24 -- Open Access
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Author(s): 
Patrick T. McGann, Anne M. Williams, Parminder S. Suchdev, et al.
Reference: 
Blood Advances 2018 2:3035-3044

In sub-Saharan Africa, inherited causes of anemia are common, but data are limited regarding the geographical prevalence and coinheritance of these conditions and their overall contributions to childhood anemia.

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Factors associated with insecticide-treated net usage among women of childbearing age in Malawi: a multilevel analysis

October 23, 2018 - 14:41 -- Open Access
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Author(s): 
Owen Nkoka, Ting-Wu Chuang, Kun-Yang Chuang and Yi-Hua Chen
Reference: 
Malaria Journal 2018 17:372, 19 October 2018

The findings confirmed the importance of assessing various factors affecting ITN usage among groups of WOCBA.

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Pharmacokinetics and Safety Profile of Artesunate-Amodiaquine Coadministered with Antiretroviral Therapy in Malaria-Uninfected HIV-Positive Malawian Adults

July 3, 2018 - 16:23 -- Open Access
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Author(s): 
Clifford G. Banda, Fraction Dzinjalamala, Mavuto Mukaka, Jane Mallewa, Victor Maiden, Dianne J. Terlouw, David G. Lalloo, Saye H. Khoo and Victor Mwapasa
Reference: 
Antimicrob. Agents Chemother. July 2018 vol. 62 no. 7 e00412-18

There are limited data on the pharmacokinetic and safety profiles of artesunate-amodiaquine in human immnunodeficiency virus-infected (HIV+) individuals receiving antiretroviral therapy.

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Household-level and surrounding peri-domestic environmental characteristics associated with malaria vectors Anopheles arabiensis and Anopheles funestus along an urban–rural continuum in Blantyre, Malawi

June 13, 2018 - 08:27 -- Open Access
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Author(s): 
Nicole F. Dear, Chifundo Kadangwe, Themba Mzilahowa, Andy Bauleni, Don P. Mathanga, Chifundo Duster, Edward D. Walker and Mark L. Wilson
Reference: 
Malaria Journal 2018 17:229, 8 June 2018

This study revealed how small-scale agriculture along a rural-to-urban transition was associated with An. arabiensis and An. funestus indoor abundances, and that indoor Anopheles density can be high within Blantyre city limits, particularly where agriculture is present

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Association between timing and number of antenatal care visits on uptake of intermittent preventive treatment for malaria during pregnancy among Malawian women

May 29, 2018 - 14:40 -- Open Access
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Author(s): 
Owen Nkoka, Ting-Wu Chuang and Yi-Hua Chen
Reference: 
Malaria Journal 2018 17:211, 25 May 2018

ANC attendance is vital in IPTp uptake.

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