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Malawi

Clinical malaria and the potential risk of anaemia among preschool-aged children: a population-based study of the 2015-2016 Malawi micronutrient survey

November 28, 2019 - 06:41 -- Open Access
Author(s): 
Ntenda PAM, Chilumpha S, Mwenyenkulu ET, Kazambwe JF, El-Meidany W.
Reference: 
Infectious Diseases of Poverty volume 8, Article number: 95 (2019)

Anaemia and malaria are common and life-threatening diseases among preschool-aged children in many tropical and subtropical areas, and Malawi is no exception. Accordingly, this study aimed to examine the association of referral clinical malaria with anemia (hemoglobin [Hb] < 110 g/L) in preschool-aged children in Malawi.

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Early malaria infection, dysregulation of angiogenesis, metabolism and inflammation across pregnancy, and risk of preterm birth in Malawi: A cohort study

October 14, 2019 - 15:22 -- Open Access
Author(s): 
Robyn E. Elphinstone, Andrea M. Weckman, Kevin C. Kain, et al.
Reference: 
PLoS Med 16(10): e1002914

Malaria in pregnancy is associated with adverse birth outcomes. However, the underlying mechanisms remain poorly understood. Tight regulation of angiogenic, metabolic, and inflammatory pathways are essential for healthy pregnancies. We hypothesized that malaria disrupts these pathways leading to preterm birth (PTB).

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Net age, but not integrity, may be associated with decreased protection against Plasmodium falciparum infection in southern Malawi

September 30, 2019 - 13:38 -- Open Access
Author(s): 
Liana R. Andronescu, Andrea G. Buchwald, Miriam K. Laufer, et al.
Reference: 
Malaria Journal 2019 18:329, 24 September 2019

Distribution campaigns for insecticide-treated nets (ITN) have increased the use of ITNs in Malawi, but malaria prevalence remains high even among those using the nets. Previous studies have addressed ITN ownership, insecticide resistance, and frequency of ITN use as possible contributing factors to the high prevalence of malaria infection despite high ITN coverage, but have rarely considered whether the condition of the ITN, or how many people use it, impacts efficacy. This study assessed how ITN integrity, ITN age, and the number of persons sharing a net might mitigate or reduce protective efficacy among self-identified ITN users in Malawi.

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Poverty and food security: drivers of insecticide-treated mosquito net misuse in Malawi

September 23, 2019 - 14:45 -- Open Access
Author(s): 
Sara Berthe, Steven A. Harvey, Matthew Lynch, Hannah Koenker, Vincent Jumbe, Blessings Kaunda-Khangamwa and Don P. Mathanga
Reference: 
Malaria Journal 2019 18:320, 18 September 2019

Over the past decade, food insecurity, connected to erratic rains and reduced agricultural outputs, has plagued Malawi. Many households are turning to fishing to seek additional sources of income and food. There is anecdotal evidence that insecticide-treated net (ITN) recipients in Malawi are using their nets for purposes other than sleeping, such as for fishing, protecting crops, and displaying merchandise, among others. The objective of this qualitative study was to explore the factors leading residents of waterside communities in Malawi to use ITNs for fishing.

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Signatures of divergent anti-malarial treatment responses in peripheral blood from adults and young children in Malawi

June 24, 2019 - 15:58 -- Open Access
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Author(s): 
Paul L. Maurizio, Hubaida Fuseini, Gerald Tegha, Mina Hosseinipour and Kristina De Paris
Reference: 
Malaria Journal 2019 18:205, 24 June 2019

Heterogeneity in the immune response to parasite infection is mediated in part by differences in host genetics, gender, and age group. In infants and young children, ongoing immunological maturation often results in increased susceptibility to infection and variable responses to drug treatment, increasing the risk of complications. Even though significant age-associated effects on host cytokine responses to Plasmodium falciparum infection have been identified, age-associated effects on uncomplicated malaria infection and anti-malarial treatment remain poorly understood.

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Intermittent screening and treatment with dihydroartemisinin-piperaquine and intermittent preventive therapy with sulfadoxine-pyrimethamine have similar effects on malaria antibody in pregnant Malawian women

June 7, 2019 - 16:56 -- Open Access
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Author(s): 
Andrew Teo, Louise M. Randall, Stephen J. Rogerson, et al.
Reference: 
Scientific Reports 9, Article number: 7878 (2019)

In a randomised trial comparing intermittent screening and treatment (IST) with dihydroartemisinin-piperaquine (DP) and intermittent preventive therapy against malaria in pregnancy (IPT) with sulfadoxine-pyrimethamine (SP) in Malawi, the impacts of IST-DP and IPT-SP on the development and maintenance of malaria antibody immunity were compared.

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Assessment of the Suna trap for sampling mosquitoes indoors and outdoors

February 28, 2019 - 15:31 -- Open Access
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Author(s): 
Monicah M. Mburu, Kennedy Zembere, Alexandra Hiscox, Jomo Banda, Kamija S. Phiri, Henk van den Berg, Themba Mzilahowa, Willem Takken and Robert S. McCann
Reference: 
Malaria Journal 2019 18:51, 22 February 2019

The efficiency of the Suna trap in sampling mosquitoes was equivalent to that of the HLC.

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The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children

January 22, 2019 - 14:51 -- Open Access
Author(s): 
Priyanka Barua, James G. Beeson, Kenneth Maleta, Per Ashorn and Stephen J. Rogerson
Reference: 
Malaria Journal 2019 18:11, 18 January 2019

Antibodies to merozoite and IE surface antigens increased following infection in early childhood, but neither age at first infection nor number of malaria episodes substantially affected antibody acquisition.

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The effect of mobile phone text message reminders on health workers’ adherence to case management guidelines for malaria and other diseases in Malawi: lessons from qualitative data from a cluster-randomized trial

January 2, 2019 - 15:31 -- Open Access
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Author(s): 
Blessings N. Kaunda-Khangamwa, Laura C. Steinhardt, Alexander K. Rowe, Austin Gumbo, Dubulao Moyo, Humphreys Nsona, Peter Troell, Dejan Zurovac and Don Mathanga
Reference: 
Malaria Journal 2018 17:481, 19 December 2018

Text-message reminders to HWs can provide a platform to improve understanding of treatment guidelines and case management decision-making skills, but might not improve actual adherence to guidelines.

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Prevalence of inherited blood disorders and associations with malaria and anemia in Malawian children

November 21, 2018 - 15:24 -- Open Access
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Author(s): 
Patrick T. McGann, Anne M. Williams, Parminder S. Suchdev, et al.
Reference: 
Blood Advances 2018 2:3035-3044

In sub-Saharan Africa, inherited causes of anemia are common, but data are limited regarding the geographical prevalence and coinheritance of these conditions and their overall contributions to childhood anemia.

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