AL, ASAQ, and DP continue to be efficacious against P. falciparum malaria in these provinces of Angola.
The results reveal important differences between provinces.
pfdhfr and pfdhps gene mutations in isolates from Lubango are suggestive of a low-grade SP resistance and IPT for pregnant women and infant based on SP treatment could be effective.
The results suggest that the high prevalence of mutant pfcrt CVIET haplotype is in agreement with low clinical efficacy of chloroquine observed in earlier studies and that the double pfdhfr mutant AICNI and single pfdhps mutant SGKAA are currently the predominant haplotypes associated with antifolate resistance in Benguela province.
A reduction in the number of malaria cases and the number of admissions due to malaria has been observed at the Hospital Nossa Senhora da Paz, during the last five years, and incidence along the study period showed a seasonal distribution.
The development of resistance to antimalarials is a major challenge for global malaria control. Artemisinin-based combination therapies, the newest class of antimalarials, are used worldwide but there have been reports of artemisinin resistance in Southeast Asia.
This study was implemented in laboratories from three hospitals in different provinces of Angola: Bengo, Benguela and Luanda. In each laboratory samples were collected before and after the training course (slide with thin and thick blood smears, a dried blood spot and a form).
DROUGHT AND MALARIA IN ANGOLA
Drought in southern Angola 2000 to 2006
When I was asked by the US Agency for International Development to go to Angola in 2005 to start the Presidential Malaria Initiative (PMI), I was told to begin spraying interiors of homes in the southern provinces of Huila and Kunene as soon as possible. I think they picked me because Portuguese is one of my favorite languages, and I had worked on malaria control in Sudan for 5 years, besides being with CDC in Puerto Rico when the island was finally declared malaria-free.
When Martinho Somandjinga, Manuel Lluberas, Joaquim Canelas and I started the US PMI in Angola in 2005, the excitement and pride of our accomplishments carried us along for the first couple of years. Sure we spent over two million dollars in one small province each year, but it seemed worth it.
Both microscopy and RDTs performed suboptimally when compared to PCR. False negativity could be associated with the low parasite density profile of the samples