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Senegal

Open Access | Use of HRP-2-based rapid diagnostic test for Plasmodium falciparum malaria: assessing accuracy and cost-effectiveness in the villages of Dielmo and Ndiop, Senegal

June 7, 2010 - 11:51 -- Kabogo Ndegwa
Author(s): 
Ly A, Tall A, Perry R, Baril L, Badiane A, Faye J, Rogier C, Toure A, Sokhna C, Trape J, Michel R
Reference: 
Malaria Journal 2010, 9:153 (4 June 2010)

A rational use of ACT requires laboratory testing of all patients presenting with presumed malaria. Use of RDTs inevitably has incremental costs, but the strategy associating RDT use for all clinically suspected malaria and prescribing ACT only to patients tested positive is cost-effective in areas where microscopy is unavailable.

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Population structure of newly established Anopheles funestus populations in the Senegal River basin using paracentric chromosomal inversions

May 25, 2010 - 09:00 -- Kabogo Ndegwa
Author(s): 
Ibrahima Dia, Badara Samb, Lassana Konate, Didier Fontenille
Reference: 
Acta Tropica, Volume 115, Issues 1-2, July-August 2010, Pages 90-94

Anopheles funestus is one of the major vectors of malaria in sub-saharan Africa. Because of several cycles of recurrent drought events that have occurred in the sahelian zone, this species had disappeared from this area since the 1970s following a disappearance of its specific breeding sites.

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Clinical Microbiology: Efficacy and tolerability of artesunate-amodiaquine (Camoquin plus®) versus artemether-lumefantrine (Coartem®) against uncomplicated Plasmodium falciparum malaria: multisite trial in Senegal and Ivory Coast

April 13, 2010 - 09:48 -- Kabogo Ndegwa
Author(s): 
Babacar Faye, André Touré Offianan, Jean Louis Ndiaye, Roger Clement Tine, Walatchin Touré, Kali Djoman, Khadime Sylla, Paulette Suzanne Ndiaye, Louis Penali, Oumar Gaye
Reference: 
Tropical Medicine & International Health, Volume 15, Issue 5, May 2010, Pages: 608-613

This study demonstrates the efficacy and tolerability of AS + AQ for uncomplicated Plasmodium falciparum malaria treatment in African patients over the age of 7 years.

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Open Access | Quinine-Resistant Malaria in Traveler Returning from Senegal, 2007

March 24, 2010 - 11:05 -- Ingeborg van Schayk
Author(s): 
B. Pradines et al.
Reference: 
EID, Volume 16, Number 3–March 2010

We describe clinical and parasitologic features of in vivo and in vitro Plasmodium falciparum resistance to quinine in a nonimmune traveler who returned to France from Senegal in 2007 with severe imported malaria. 

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Open Access | Clinical Therapeutics: Amodiaquine Dosage and Tolerability for Intermittent Preventive Treatment To Prevent Malaria in Children

February 25, 2010 - 13:49 -- Kabogo Ndegwa
Author(s): 
M. Cairns, B. Cisse, C. Sokhna, C. Cames, K. Simondon, E. H. Ba, J.-F. Trape, O. Gaye, B. M. Greenwood, and P. J. M. Milligan
Reference: 
Antimicrobial Agents and Chemotherapy, March 2010, Pages 1265-1274, Volume 54, No. 3

We determined the association between amodiaquine dosage by body weight and mild adverse events (AEs) and investigated whether alternative age-based regimens could improve dosing accuracy and tolerability, using data from two trials of IPTc in Senegal, one in which AQ dose was determined by age and the other in which it was determined by weight category.

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Brief report: A Non-Radioactive DAPI-based High-Throughput In Vitro Assay to Assess Plasmodium falciparum Responsiveness to Antimalarials—Increased Sensitivity of P. falciparum to Chloroquine in Senegal

February 11, 2010 - 12:56 -- Ingeborg van Schayk
Author(s): 
Daouda Ndiaye, Vishal Patel, Allison Demas, Michele LeRoux, Omar Ndir, Souleymane Mboup, Jon Clardy, Viswanathan Lakshmanan, Johanna P. Daily, AND Dyann F. Wirth
Reference: 
Am J Trop Med Hyg 2010;82 228-230

Therefore, the implementation of non-radioactive, robust, high-throughput antimalarial sensitivity assays is critical for defining region-specific prophylaxis and treatment guidelines.

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Community and International Nutrition: Active Malaria Morbidity Management Has Limited Impact on Height Status of Preschool Senegalese Children

January 31, 2010 - 13:27 -- Ingeborg van Schayk
Author(s): 
Florie Fillol, Amandine Cournil, Cécile Cames, Cheikh Sokhna and Kirsten Bork Simondon
Reference: 
J. Nutr. (January 20, 2010). doi:10.3945/jn.109.114223

These findings suggest that improved health services provided by the trial may also have benefited children not included living in study villages.

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A Randomized Trial of Artesunate Mefloquine versus Artemether Lumefantrine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in Senegalese Children

January 14, 2010 - 10:55 -- Ingeborg van Schayk
Author(s): 
Babacar Faye, Jean Louis Ndiaye, Roger Tine, Khadim Sylla, Ali Gueye, Aminata Colle Lô, AND Oumar Gaye
Reference: 
Am J Trop Med Hyg 2010;82 140-144

An open randomized clinical trial study was carried out to compare efficacy and tolerability of artesunate mefloquine 25 mg/kg body weight (Artequin paediatric) versus artemether lumefantrine (Coartem) in the treatment of uncomplicated Plasmodium falciparum malaria in children.

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Open Access | Evolution of malaria mortality and morbidity after the emergence of chloroquine resistance in Niakhar, Senegal

December 8, 2009 - 11:39 -- Ingeborg van Schayk
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Author(s): 
Aline Munier, Aldiouma Diallo, Adama Marra, Michel Cot, Pascal Arduin, Ousmane Ndiaye, Balla Mbacké Mboup, Barnabé Gning, Jean-Philippe Chippaux
Reference: 
Malaria Journal 2009, 8:270 (27 November 2009)

The study aimed to assess the impact of chemoresistance on mortality attributable to malaria in a rural area of Senegal.

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Self-reported data: a major tool to assess compliance with anti-malarial combination therapy among children in Senegal

November 26, 2009 - 11:48 -- Ingeborg van Schayk
Author(s): 
Aurelia Souares, Patricia Moulin, Sophie Sarrassat, Marie-Paule Carlotti, Richard Lalou, Jean-Yves Le Hesran
Reference: 
Malaria Journal 2009, 8:257 (17 November 2009)

Different techniques used to measure compliance were compared among children treated by the anti-malarial amodiaquine/sulphadoxine-pyrimethamine (AQ/SP) combination therapy, in use in Senegal between 2004 and 2006.

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