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Senegal

Open Access | Changing patterns of malaria during 1996-2010 in an area of moderate transmission in Southern Senegal

July 26, 2011 - 07:22 -- Kabogo Ndegwa
Author(s): 
Brasseur P, Badiane M, Cisse M, Agnamey P, Vaillant MT, Olliaro PL
Reference: 
Malaria Journal 2011, 10:203 (25 July 2011)

This study provides direct evidence of malaria risk receding between 1996-2010 and becoming equal throughout life where transmission used to be moderate.

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Prevalence of molecular markers of Plasmodium falciparum resistance to sulfadoxine–pyrimethamine during the intermittent preventive treatment in infants coupled with the expanded program immunization in Senegal

June 23, 2011 - 06:59 -- Kabogo Ndegwa
Author(s): 
Babacar Faye, Magatte Ndiaye, Oumar Gaye, et al.
Reference: 
Parasitology Research, Volume 109, Number 1, 133-138

Several studies have shown the efficacy of the intermittent preventive treatment (IPT) using sulfadoxine–pyrimethamine (SP) coupled with the expanded program of immunization (EPI) in infants.

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Open Access | Icacina senegalensis (Icacinaceae), traditionally used for the treatment of malaria, inhibits in vitro Plasmodium falciparum growth without host cell toxicity

April 20, 2011 - 12:17 -- Kabogo Ndegwa
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Author(s): 
Serigne O Sarr, Sylvie Perrotey, Ibrahima Fall, Said Ennahar, Minjie Zhao, Yerim M Diop, Ermanno Candolfi, Eric Marchioni
Reference: 
Malaria Journal 2011, 10:85 (11 April 2011)

Anti-plasmodial activity and toxicity of I. senegalensis are reported for the first time and showed promising results in malaria field research.

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Schistosoma haematobium infection affects Plasmodium falciparum-specific IgG responses associated with protection against malaria

January 18, 2011 - 06:42 -- Kabogo Ndegwa
Author(s): 
D. Courtin, A. Djilali-Saiah, J. Milet, V. Soulard, O. Gaye, F. Migot-Nabias, R. Sauerwein, A. Garcia, A.J.F. Luty
Reference: 
Parasite Immunology, Volume 33, Issue 2, pages 124–131, February 2011

We have previously shown that antibody responses directed to Plasmodium falciparum merozoite surface protein (MSP)-1, MSP-2 and glutamate-rich protein (GLURP) are associated with anti-malarial protection in residents of the Niakhar area of Senegal.

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Open Access | Immunological consequences of intermittent preventive treatment against malaria in Senegalese preschool children

December 20, 2010 - 12:55 -- Kabogo Ndegwa
Author(s): 
Boulanger D, Sarr J, Fillol F, Sokhna C, Cisse B, Schacht A, Trape J, Riveau G, Simondon F, Greenwood B, Remoue F
Reference: 
Malaria Journal 2010, 9:363 (17 December 2010)

The intensity of the contacts with P. falciparum seems to represent the main factor influencing anti-schizont IgG responses.

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Open Access | From fever to anti-malarial: the treatment-seeking process in rural Senegal

November 24, 2010 - 10:08 -- Kabogo Ndegwa
Author(s): 
Lucy A Smith, Jane Bruce, Lamine Gueye, Anthony Helou, Rodio Diallo, Babacar Gueye, Caroline Jones, Jayne Webster
Reference: 
Malaria Journal 2010, 9:333 (22 November 2010)

Process analysis of the treatment pathway for febrile children must be stratified by sector of treatment-seeking.

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Open Access | Spatial heterogeneity and temporal evolution of malaria transmission risk in Dakar, Senegal, according to remotely sensed environmental data

September 7, 2010 - 14:15 -- Kabogo Ndegwa
Author(s): 
Machault V, Vignolles C, Pages F, Gadiaga L, Gaye A, Sokhna C, Trape J, Lacaux J, Rogier C
Reference: 
Malaria Journal 2010, 9:252 (3 September 2010)

Environmental data retrieved from high spatial resolution SPOT satellite images were associated with An. arabiensis densities in Dakar urban setting, which allowed to generate malaria transmission risk maps.

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Conference Report | MALVAC 2009: Progress and Challenges in Development of Whole Organism Malaria Vaccines for Endemic Countries, 3–4 June 2009, Dakar, Senegal

July 6, 2010 - 07:42 -- Patrick Sampao
Author(s): 
M. Pinder, V.S. Moorthy, B.D. Akanmori, B. Genton, G.V. Brown
Reference: 
Vaccine, Volume 28, Issue 30, 5 July 2010, Pages 4695-4702

A group of leading scientists, clinical trialists and stakeholders, together with representatives of regulatory authorities including some from African countries, met recently to document the issues that will require detailed consideration to assess this promising approach. Questions related to scale-up, quality, purity and consistency of a manufacturing process using mosquitoes to generate a commercial product, and demonstration of the stability of attenuated sporozoites will need further work.

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Open Access | Heritability of the Human Infectious Reservoir of Malaria Parasites

July 2, 2010 - 11:11 -- Kabogo Ndegwa
Author(s): 
Yaye Ramatoulaye Lawaly, Anavaj Sakuntabhai, Rick Paul, et al
Reference: 
PLoS ONE 5(6): e11358

The existence of a significant human genetic contribution to gametocyte prevalence in asymptomatic infections suggests that candidate gene and genome wide association approaches may be usefully applied to explore the underlying human genetics.

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Open Access | Plasmodium falciparum population dynamics in a cohort of pregnant women in Senegal

June 18, 2010 - 11:37 -- Kabogo Ndegwa
Author(s): 
Guitard J, Andersen P, Ermont C, Gnidehou S, Fievet N, Lund O, Deloron P, Tuikue Ndam N
Reference: 
Malaria Journal 2010, 9:165 (16 June 2010)

Host immunity to VAR2CSA influences the parasite dynamics during pregnancy, suggesting that the acquisition of protective immunity requires pre-exposure to a limited number of parasite variants.

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