We monitored and analysed the changes in malaria epidemiology in a village community in Senegal, west Africa, over 22 years.
These results warrant deeper monitoring of the RDT target antigen diversity and emphasize that development of other essential genes as a target for diagnostic tools is critical.
The primary end point of the study was represented by a PCR adjusted adequate clinical and parasitological response (ACPR) at day 28.
The main objective of this work was to study the spatio-temporal host preferences and blood-feeding patterns of malaria vectors in a pastoral area of Senegal where cattle breeding is the main human activity.
The primary risk factor for malaria infection in the low transmission district of Richard Toll is travel.
The results strengthen the hypothesis that malaria transmission is maintained during the dry season in an area of low and seasonal transmission.
This study examined routine reporting data from a CCMm programme between 2008 and 2011 in Saraya, a rural district in Senegal, and assessed its impact on timely access to rapid diagnostic tests and ACT.
Although the World Health Organization recommends replacing quinine (QN) by artesunate due to its increased efficacy and the higher tolerance to the drug in both adults and children, QN remains a first-line treatment for severe malaria, especially in Africa.
Our study investigated the possible impact of SP-IPT given to infants and children on the prevalence of SP-resistant haplotypes in the Plasmodium falciparum genes Pfdhfr and Pfdhps, comparing sites with and without IPTi/c. P. falciparum positive samples (N = 352) collected from children < 5 years were analyzed to determine the prevalence of SP resistance-related haplotypes by nested PCR followed by sequence-specific oligonucleotide probe-enzyme-linked immunosorbent assay.
The sensitivity of P. falciparum to SMC drugs should be regularly monitored in areas deploying this intervention.