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Gabon

Open Access | Induction of Plasmodium falciparum-Specific CD4+ T Cells and Memory B Cells in Gabonese Children Vaccinated with RTS,S/AS01E and RTS,S/AS02D

April 19, 2011 - 06:50 -- Kabogo Ndegwa
Author(s): 
Selidji T. Agnandji, Rolf Fendel, Benjamin Mordmüller, et al.
Reference: 
PLoS ONE 6(4): e18559

The recombinant circumsporozoite protein (CS) based vaccine, RTS,S, confers protection against Plasmodium falciparum infection in controlled challenge trials and in field studies.

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In vitro activity of new artemisinin derivatives against Plasmodium falciparum clinical isolates from Gabon

April 12, 2011 - 07:46 -- Kabogo Ndegwa
Author(s): 
Jana Held, Shahid A. Soomro, Peter G. Kremsner, F. Herwig Jansen, Benjamin Mordmüller
Reference: 
International Journal of Antimicrobial Agents Volume 37, Issue 5, May 2011, Pages 485-488

Nowadays, artemisinins are the mainstay of malaria treatment, but initial indications of resistance against clinically used derivatives are present.

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Increased prevalence of the Plasmodium falciparum Pfmdr1 86N genotype among field isolates from Franceville, Gabon after replacement of chloroquine by artemether–lumefantrine and artesunate–mefloquine

March 1, 2011 - 08:11 -- Patrick Sampao
Author(s): 
Jean Bernard Lekana-Douki.,Sylvatrie Danne Dinzouna Boutamba., Fousseyni S. Toure-Ndouo., et al.
Reference: 
Infection, Genetics and Evolution, Volume 11, Issue 2, March 2011, Pages 512-517

These findings show a substantial benefice of artemether–lumefantrine and artesunate–mefloquine and of new control measures.

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Open Access | Prevalence of Plasmodium falciparum infection in asymptomatic rural Gabonese populations

February 10, 2011 - 11:51 -- Kabogo Ndegwa
Author(s): 
Nkoghe D, Akue J, Gonzalez J, Leroy EM
Reference: 
Malaria Journal 2011, 10:33 (9 February 2011)

Plasmodium falciparum carriage remains high among adults in rural Gabon. Control measures must be adapted to the region and ecosystem. Routine treatment of asymptomatic individuals should be considered.

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In vitro antiplasmodial activity and cytotoxicity of nine plants traditionally used in Gabon

February 2, 2011 - 12:26 -- Patrick Sampao
Author(s): 
Jean Bernard Lekana-Douki., Jean Bernard Bongui., Maryvonne Kombila., et al.
Reference: 
Journal of Ethnopharmacology, Volume 133, Issue 3, 16 February 2011, Pages 1103-1108

As part of a project to identify new compounds active on malarial parasites, we tested the in vitro antiplasmodial activity of nine plants traditionally used to treat malaria symptoms in Haut-Ogooué Province, South-East Gabon.

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Open Access | Malaria transmission and insecticide resistance of Anopheles gambiae s.l. in Libreville and Port-Gentil, Gabon

November 17, 2010 - 12:47 -- Kabogo Ndegwa
Author(s): 
Jean-Romain Mourou, Thierry Coffinet, Fanny Jarjaval, Bruno Pradines, Remi Amalvict, Christophe Rogier, Maryvonne Kombila, Frederic Pages
Reference: 
Malaria Journal 2010, 9:321 (11 November 2010)

Malaria transmission exists in both town, but with high difference in the level of risk.

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Efficacy and safety of a new pediatric artesunate-mefloquine drug formulation for the treatment of uncomplicated falciparum malaria in Gabon

April 8, 2010 - 12:50 -- Kabogo Ndegwa
Author(s): 
MK Bouyou-Akotet, M Ramharter, EB Ngoungou, MM Mamfoumbi, MP Mihindou, MA Missinou, F Kurth, S Bélard, ST Agnandji, S Issifou, JL Heidecker, S Trapp, PG Kremsner, M Kombila
Reference: 
Wiener Klinische Wochenschrift, Volume 122, Numbers 5-6 / March, 2010 Pages 173-178

Pediatric drug formulations of artemisinin combination therapies are urgently needed for improving the treatment of children suffering from uncomplicated malaria. The aim of this clinical trial was to evaluate the efficacy, safety and tolerability of a novel pediatric fixed-dose granule formulation of artesunate-mefloquine and a new co-blister tablet formulation.

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High prevalence of sulfadoxine/pyrimethamine-resistant alleles of Plasmodium falciparum isolates in pregnant women at the time of introduction of intermittent preventive treatment with sulfadoxine/pyrimethamine in Gabon

March 10, 2010 - 13:58 -- Ingeborg van Schayk
Author(s): 
Marielle Karine Bouyou-Akotet, Denise Patricia Mawili-Mboumba, Tanguy de Dieu Tchantchou, and Maryvonne Kombila
Reference: 
J. Antimicrob. Chemother. 2010 65: 438-441

These findings underline the need for a regular assessment of the relationship between the presence of resistant isolates and in vitro/in vivo IPTp/SP efficacy, and evaluation of an alternative drug.

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Burden of Malaria during Pregnancy at the Time of IPTp/SP Implementation in Gabon

February 10, 2010 - 21:12 -- Ingeborg van Schayk
Author(s): 
Marielle K. Bouyou-Akotet, Solange Nzenze-Afene, Edgard B. Ngoungou, Eric Kendjo, Mathieu Owono-Medang, Jean-Bernard Lekana-Douki, Ghislaine Obono-Obiang, Mathieu Mounanga, AND Maryvonne Kombila
Reference: 
Am J Trop Med Hyg 2010;82 202-209

The use of intermittent preventive treatment with sulfadoxine-pyrimethamine (greater than or equal to one dose) combined with bed net was associated with a reduction in infection only in multigravidae and with a reduced risk of maternal anemia.

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Parasitology: Evaluation of rapid diagnostic tests for malaria case management in Gabon

January 21, 2010 - 07:50 -- Kabogo Ndegwa
Author(s): 
Denise Patricia Mawili-Mboumba, Marielle Karine Bouyou Akoteta, Edgard Brice Ngoungoua and Maryvonne Kombila
Reference: 
Diagnostic Microbiology and Infectious Disease, Volume 66, Issue 2, February 2010, Pages 162-168

These tests should be considered as a good alternative to microscopy, allowing not only an efficient and rapid diagnosis of malaria in primary health facilities but also to aid in promoting changes for antimalarial prescription behavior.

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