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Gabon

In vitro antimalarial susceptibility and molecular markers of drug resistance in Franceville, Gabon

November 19, 2012 - 05:09 -- Open Access
Author(s): 
Zatra R, Lekana-douki JB, Lekoulou F, Bisvigou U, Ngoungou EB, Ndouo FS
Reference: 
BMC Infectious Diseases 2012, 12:307 (15 November 2012)
MalariaWorld

The aims of this study were to analyze the in vitro sensitivity of P. falciparum field isolates from Franceville, Gabon, to chloroquine (CQ), mefloquine (MF), dihydroartemisinine (DHA) and monodesethylamodiaquine (MDAQ), and to investigate polymorphisms associated with drug resistance.

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Complicated malaria and other severe febrile illness in a pediatric ward in Libreville, Gabon

September 18, 2012 - 17:05 -- Patrick Sampao
Author(s): 
Bouyou-Akotet MK, Mawili-Mboumba DP, Kendjo E, Eyang Ekouma A, Abdou Raouf O, Engohan Allogho E, Kombila M
Reference: 
BMC Infectious Diseases 2012, 12:216 (13 September 2012)

MalariaWorldThe present study was designed to assess the management of febrile illness and to determine the proportion of children with febrile illness hospitalized for primary diagnosis of malaria who had confirmed complicated malaria after implementation of new malaria control strategies in Libreville, Gabon.

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Open Access | Prospective evaluation of artemether-lumefantrine for the treatment of non-falciparum and mixedspecies malaria in Gabon

April 26, 2012 - 13:05 -- Kabogo Ndegwa
Author(s): 
Mombo-Ngoma G, Kleine C, Basra A, Würbel H, Diop DA, Capan M, Adegnika AA, Kurth F, Mordmüller B, Joanny F, Kremsner PG, Ramharter M, Bélard S
Reference: 
Malaria Journal 2012, 11:120 (19 April 2012)

MalariaWorldThis first systematic assessment of artemether-lumefantrine treatment for P. malariae, P. ovale and mixed-species malaria demonstrated a high cure rate of 100% and a favourable tolerability profile, and thus lends support to the practice of treating non-falciparum or mixed-species malaria, or indeed all clinically suspected cases of malaria, with artemetherlumefantrine in Gabon.

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In vitro antiplasmodial activity and cytotoxicity of extracts and fractions of Vitex madiensis, medicinal plant of Gabon

February 23, 2012 - 10:15 -- Kabogo Ndegwa
Author(s): 
J. P. Ondo, J. B. Lekana-Douki, J. B. Bongui, E. S. Zang Edou, R. Zatra, F. S. Toure-Ndouo, A. Elomri, J. Lebibi and E. Seguin
Reference: 
Tropical Medicine & International Health, Volume 17, Issue 3, pages 316–321, March 2012

MalariaWorldVitex madiensis Oliv. (Lamiaceae) is traditionally used to treat malaria symptoms in Haut-Ogooué, Gabon.

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Open Access | Malaria transmission in Libreville: results of a one year survey

February 14, 2012 - 13:37 -- Kabogo Ndegwa
Author(s): 
Mourou J, Coffinet T, Jarjaval F, Cotteaux C, Pradines E, Lydie G, Kombila M, Pages F
Reference: 
Malaria Journal 2012, 11:40 (9 February 2012)

MalariaWorldMalaria transmission in Libreville occurred mainly during the rainy season but also during the dry season in the five districts.

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Open Access | Cost-effectiveness of intermittent preventive treatment of malaria in infants (IPTi) for averting anaemia in Gabon: a comparison between intention to treat and according to protocol analyses

October 19, 2011 - 07:31 -- Kabogo Ndegwa
Author(s): 
Sicuri E, Biao P, Hutton G, Tediosi F, Menendez C, Lell B, Kremsner P, Conteh L, Grobusch MP
Reference: 
Malaria Journal 2011, 10:305 (17 October 2011)

MalariaWorldMigration implies great challenges in the organization of health interventions that require repeat visits in Gabon.

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Open Access | A thirteen-year analysis of Plasmodium falciparum populations reveals high conservation of the mutant pfcrt haplotype despite the withdrawal of chloroquine from national treatment guidelines in Gabon

October 19, 2011 - 07:26 -- Kabogo Ndegwa
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Author(s): 
Frank M, Lehners N, Mayengue PI, Gabor J, Dal-Bianco M, Kombila DU, Mombo Ngoma G, Supan C, Lell B, Ntoumi F, Grobusch MP, Dietz K, Kremsner PG
Reference: 
Malaria Journal 2011, 10:304 (17 October 2011)

MalariaWorldFour years after the withdrawal of CQ from national treatment guidelines the prevalence of the mutant pfcrt allele remains at 97%.

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Open Access | A Randomized Controlled Phase Ib Trial of the Malaria Vaccine Candidate GMZ2 in African Children

August 4, 2011 - 09:28 -- Kabogo Ndegwa
Author(s): 
Sabine Bélard, Saadou Issifou, Benjamin Mordmüller, et al.
Reference: 
PLoS ONE 6(7): e22525

Both 30 µg as well as 100 µg intramuscular GMZ2 are immunogenic, well tolerated, and safe in young, malaria-exposed Gabonese children.

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Open Access | Assessment of LED fluorescence microscopy for the diagnosis of Plasmodium falciparum infections in Gabon

July 19, 2011 - 08:35 -- Kabogo Ndegwa
Author(s): 
Lenz D, Kremsner PG, Lell B, Biallas B, Boettcher M, Mordmuller B, Adegnika AA
Reference: 
Malaria Journal 2011, 10:194 (18 July 2011)

ledFM is a reliable, accurate, fast and inexpensive tool for daily routine malaria diagnosis and may be used as a point of care diagnostic tool.

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Open Access | High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children

May 18, 2011 - 10:13 -- Kabogo Ndegwa
Author(s): 
Ghyslain Mombo-Ngoma, Sunny Oyakhirome, Rosalynn Ord, Julian J Gabor, Katja C Greutelaers, Katharina Profanter, Benedikt Greutelaers, Florian Kurth, Bertrand Lell, Juergen FJ Kun, Saadou Issifou, Cally Roper, Peter G Kremsner, Martin P Grobusch
Reference: 
Malaria Journal 2011, 10:123 (14 May 2011)

There is a high prevalence of dhfr triple mutant with some dhps point mutations in Gabon, in line with treatment failures observed, and molecular markers of SP resistance should be closely monitored.

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