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Gabon

DNA recovery from archived RDTs for genetic characterization of Plasmodium falciparum in a routine setting in Lambaréné, Gabon

October 7, 2019 - 15:28 -- Open Access
Author(s): 
The Trong Nguyen, Brice Nzigou Mombo, Ghyslain Mombo-Ngoma, et al.
Reference: 
Malaria Journal 2019 18:336, 2 October 2019

Rapid diagnostic tests (RDTs) have been described as a source of genetic material to analyse malaria parasites in proof-of-concept studies. The increasing use of RDTs (e.g., in focal or mass screening and treatment campaigns) makes this approach particularly attractive for large-scale investigations of parasite populations. In this study, the complexity of Plasmodium falciparum infections, parasite load and chloroquine resistance transporter gene mutations were investigated in DNA samples extracted from positive RDTs, obtained in a routine setting and archived at ambient temperature.

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NOT Open Access | Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon

February 6, 2019 - 15:24 -- NOT Open Access
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Author(s): 
Michael Ramharter, Matthias Schwab, Thorsten Lehr, et al.
Reference: 
Antimicrob. Agents Chemother. January 2019 63:e01113-18

Mefloquine was evaluated as an alternative for intermittent preventive treatment of malaria in pregnancy (IPTp) due to increasing resistance against the first-line drug sulfadoxine-pyrimethamine (SP).

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Genetic diversity of Plasmodium falciparum isolates from Baka Pygmies and their Bantu neighbours in the north of Gabon

October 13, 2015 - 11:03 -- Open Access
Author(s): 
Bertrand Mvé-Ondo, Dieudonné Nkoghe, Benjamin Ollomo, et al.
Reference: 
Malaria Journal 2015, 14:395 (9 October 2015)

The prevalence and genetic diversity of P. falciparum observed in Baka demonstrates a significant transmission of the parasite in this population, and some exchanges of parasites with Bantu neighbours.

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Co-infection of human parvovirus B19 with Plasmodium falciparum contributes to malaria disease severity in Gabonese patients

August 27, 2013 - 18:49 -- Open Access
Author(s): 
Nguyen L Toan, Bui T Sy, Le H Song, Hoang V Luong, Nguyen T Binh, Vu Q Binh, Reinhard Kandolf, Thirumalaisamy P Velavan, Peter G Kremsner and C-Thomas Bock
Reference: 
BMC Infectious Diseases 2013, 13:375
MalariaWorld

Our findings reveal that B19V-infection is frequent in Gabonese children with P. falciparum malaria and signifies a possible contribution of B19V on the clinical course of malaria in a genotype-dependent manner.

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Increase in malaria prevalence and age of at risk population in different areas of Gabon

January 8, 2013 - 09:04 -- Open Access
Author(s): 
Mawili-Mboumba DP, Akotet MK, Kendjo E, Nzamba J, Medang MO, Mbina JM, Kombila M
Reference: 
Malaria Journal 2013, 12:3 (2 January 2013)
MalariaWorld

This study shows an increased risk of malaria infection in different areas of Gabon with over-five year-old children tending to become the most at-risk population, suggesting a changing epidemiology.

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In vitro antimalarial susceptibility and molecular markers of drug resistance in Franceville, Gabon

November 19, 2012 - 05:09 -- Open Access
Author(s): 
Zatra R, Lekana-douki JB, Lekoulou F, Bisvigou U, Ngoungou EB, Ndouo FS
Reference: 
BMC Infectious Diseases 2012, 12:307 (15 November 2012)
MalariaWorld

The aims of this study were to analyze the in vitro sensitivity of P. falciparum field isolates from Franceville, Gabon, to chloroquine (CQ), mefloquine (MF), dihydroartemisinine (DHA) and monodesethylamodiaquine (MDAQ), and to investigate polymorphisms associated with drug resistance.

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Complicated malaria and other severe febrile illness in a pediatric ward in Libreville, Gabon

September 18, 2012 - 17:05 -- Patrick Sampao
Author(s): 
Bouyou-Akotet MK, Mawili-Mboumba DP, Kendjo E, Eyang Ekouma A, Abdou Raouf O, Engohan Allogho E, Kombila M
Reference: 
BMC Infectious Diseases 2012, 12:216 (13 September 2012)

MalariaWorldThe present study was designed to assess the management of febrile illness and to determine the proportion of children with febrile illness hospitalized for primary diagnosis of malaria who had confirmed complicated malaria after implementation of new malaria control strategies in Libreville, Gabon.

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Open Access | Prospective evaluation of artemether-lumefantrine for the treatment of non-falciparum and mixedspecies malaria in Gabon

April 26, 2012 - 13:05 -- Kabogo Ndegwa
Author(s): 
Mombo-Ngoma G, Kleine C, Basra A, Würbel H, Diop DA, Capan M, Adegnika AA, Kurth F, Mordmüller B, Joanny F, Kremsner PG, Ramharter M, Bélard S
Reference: 
Malaria Journal 2012, 11:120 (19 April 2012)

MalariaWorldThis first systematic assessment of artemether-lumefantrine treatment for P. malariae, P. ovale and mixed-species malaria demonstrated a high cure rate of 100% and a favourable tolerability profile, and thus lends support to the practice of treating non-falciparum or mixed-species malaria, or indeed all clinically suspected cases of malaria, with artemetherlumefantrine in Gabon.

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In vitro antiplasmodial activity and cytotoxicity of extracts and fractions of Vitex madiensis, medicinal plant of Gabon

February 23, 2012 - 10:15 -- Kabogo Ndegwa
Author(s): 
J. P. Ondo, J. B. Lekana-Douki, J. B. Bongui, E. S. Zang Edou, R. Zatra, F. S. Toure-Ndouo, A. Elomri, J. Lebibi and E. Seguin
Reference: 
Tropical Medicine & International Health, Volume 17, Issue 3, pages 316–321, March 2012

MalariaWorldVitex madiensis Oliv. (Lamiaceae) is traditionally used to treat malaria symptoms in Haut-Ogooué, Gabon.

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Open Access | Malaria transmission in Libreville: results of a one year survey

February 14, 2012 - 13:37 -- Kabogo Ndegwa
Author(s): 
Mourou J, Coffinet T, Jarjaval F, Cotteaux C, Pradines E, Lydie G, Kombila M, Pages F
Reference: 
Malaria Journal 2012, 11:40 (9 February 2012)

MalariaWorldMalaria transmission in Libreville occurred mainly during the rainy season but also during the dry season in the five districts.

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