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Gabon

Description of Plasmodium falciparum infections in central Gabon demonstrating high parasite densities among symptomatic adolescents and adults

November 30, 2019 - 12:24 -- Open Access
Author(s): 
Zoleko Manego R, Koehne E, Mombo-Ngoma G, et al.
Reference: 
Malar J. 2019 Nov 21;18(1):371

Malaria remains a public health issue, particularly in sub-Saharan Africa with special features of seriousness in young children and pregnant women. Adolescents and adults are reported to have acquired a semi-immune status and, therefore, present with low parasitaemia. Children are understood to present with a much higher parasitaemia and severe malaria. It is a concern that effective malaria control programmes targeting young children may lead to a delay in the acquisition of acquired immunity and, therefore, causing a shift in the epidemiology of malaria. Prevalence and parasitaemia were explored in adolescents and adults with Plasmodium falciparum infections compared to young children in the area of Lambaréné, Gabon as an indicator for semi-immunity. 

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NOT Open Access | High Circulation of Malaria and Low Prevalence of Bacteremia in Febrile and Afebrile Children in Northeastern Gabon

November 27, 2019 - 16:05 -- NOT Open Access
Author(s): 
Boumbanda Koyo CS, Oyegue-Liabagui SL, Mediannikov O, Cortaredona S, Kouna LC, Raoult D, Lekana-Douki JB, Fenollar F.
Reference: 
Am J Trop Med Hyg. 2019 Nov 25.

The epidemiology of febrile illness etiologies is under-explored in resource-poor settings. Establishing a local repertory of microorganisms circulating in blood of febrile and afebrile people is important for physicians. Blood was collected from 428 febrile and 88 afebrile children in Makokou (Gabon) and analyzed using polymerase chain reaction. Plasmodium spp. were the pathogens, which were most detected in febrile children (69.6%; 298/428) and in afebrile children (31.8%; 28/88) (P < 0.0001). Plasmodium falciparum was the most prevalent species in both febrile and afebrile children (66.8% and 27.3%, respectively).

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Monitoring the threatened utility of malaria rapid diagnostic tests by novel high-throughput detection of Plasmodium falciparum hrp2 and hrp3 deletions: A cross-sectional, diagnostic accuracy study

November 26, 2019 - 20:43 -- Open Access
Author(s): 
Kreidenweiss A, Trauner F, Sandri TL, et al.
Reference: 
EBioMedicine. 2019 Nov 21. pii: S2352-3964(19)30723-6.

Plasmodium falciparum deficient for hrp2 and hrp3 genes are a threat to malaria management and elimination, since they escape widely used HRP2-based rapid diagnostic tests and treatment. Hrp2/hrp3 deletions are increasingly reported from all malaria endemic regions but are currently only identified by laborious methodologies.

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Description of Plasmodium falciparum infections in central Gabon demonstrating high parasite densities among symptomatic adolescents and adults

November 26, 2019 - 14:40 -- Open Access
Author(s): 
Rella Zoleko Manego, Erik Koehne, Andrea Kreidenweiss, Brice Nzigou Mombo, Bayode Romeo Adegbite, Lia Betty Dimessa Mbadinga, Malik Akinosho, Julian Matthewman, Ayola Akim Adegnika, Michael Ramharter and Ghyslain Mombo-Ngoma
Reference: 
Malaria Journal 2019 18:371, 21 November 2019

Malaria remains a public health issue, particularly in sub-Saharan Africa with special features of seriousness in young children and pregnant women. Adolescents and adults are reported to have acquired a semi-immune status and, therefore, present with low parasitaemia. Children are understood to present with a much higher parasitaemia and severe malaria. It is a concern that effective malaria control programmes targeting young children may lead to a delay in the acquisition of acquired immunity and, therefore, causing a shift in the epidemiology of malaria. Prevalence and parasitaemia were explored in adolescents and adults with Plasmodium falciparum infections compared to young children in the area of Lambaréné, Gabon as an indicator for semi-immunity.

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Histone deacetylase inhibitors with high in vitro activities against Plasmodium falciparum isolates collected from Gabonese children and adults

November 26, 2019 - 13:39 -- Open Access
Author(s): 
Koehne E, Kreidenweiss A, Zoleko Manego R, McCall M, Mombo-Ngoma G, Mackwitz MKW, Hansen FK, Held J.
Reference: 
Scientific Reports volume 9, Article number: 17336 (2019)

Histone deacetylase (HDAC) enzymes are targets for the development of antimalarial drugs with a different mode of action to established antimalarials. Broad-spectrum HDAC-inhibitors show high potency against Plasmodium falciparum, but displayed some toxicity towards human cells. Inhibitors of human HDAC6 are new drug candidates with supposed reduced toxicity to human cells and favorable activities against laboratory P. falciparum strains.

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DNA recovery from archived RDTs for genetic characterization of Plasmodium falciparum in a routine setting in Lambaréné, Gabon

October 7, 2019 - 15:28 -- Open Access
Author(s): 
The Trong Nguyen, Brice Nzigou Mombo, Ghyslain Mombo-Ngoma, et al.
Reference: 
Malaria Journal 2019 18:336, 2 October 2019

Rapid diagnostic tests (RDTs) have been described as a source of genetic material to analyse malaria parasites in proof-of-concept studies. The increasing use of RDTs (e.g., in focal or mass screening and treatment campaigns) makes this approach particularly attractive for large-scale investigations of parasite populations. In this study, the complexity of Plasmodium falciparum infections, parasite load and chloroquine resistance transporter gene mutations were investigated in DNA samples extracted from positive RDTs, obtained in a routine setting and archived at ambient temperature.

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NOT Open Access | Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon

February 6, 2019 - 15:24 -- NOT Open Access
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Author(s): 
Michael Ramharter, Matthias Schwab, Thorsten Lehr, et al.
Reference: 
Antimicrob. Agents Chemother. January 2019 63:e01113-18

Mefloquine was evaluated as an alternative for intermittent preventive treatment of malaria in pregnancy (IPTp) due to increasing resistance against the first-line drug sulfadoxine-pyrimethamine (SP).

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Genetic diversity of Plasmodium falciparum isolates from Baka Pygmies and their Bantu neighbours in the north of Gabon

October 13, 2015 - 11:03 -- Open Access
Author(s): 
Bertrand Mvé-Ondo, Dieudonné Nkoghe, Benjamin Ollomo, et al.
Reference: 
Malaria Journal 2015, 14:395 (9 October 2015)

The prevalence and genetic diversity of P. falciparum observed in Baka demonstrates a significant transmission of the parasite in this population, and some exchanges of parasites with Bantu neighbours.

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Co-infection of human parvovirus B19 with Plasmodium falciparum contributes to malaria disease severity in Gabonese patients

August 27, 2013 - 18:49 -- Open Access
Author(s): 
Nguyen L Toan, Bui T Sy, Le H Song, Hoang V Luong, Nguyen T Binh, Vu Q Binh, Reinhard Kandolf, Thirumalaisamy P Velavan, Peter G Kremsner and C-Thomas Bock
Reference: 
BMC Infectious Diseases 2013, 13:375
MalariaWorld

Our findings reveal that B19V-infection is frequent in Gabonese children with P. falciparum malaria and signifies a possible contribution of B19V on the clinical course of malaria in a genotype-dependent manner.

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Increase in malaria prevalence and age of at risk population in different areas of Gabon

January 8, 2013 - 09:04 -- Open Access
Author(s): 
Mawili-Mboumba DP, Akotet MK, Kendjo E, Nzamba J, Medang MO, Mbina JM, Kombila M
Reference: 
Malaria Journal 2013, 12:3 (2 January 2013)
MalariaWorld

This study shows an increased risk of malaria infection in different areas of Gabon with over-five year-old children tending to become the most at-risk population, suggesting a changing epidemiology.

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