This study was conducted at the Gushegu District Hospital in Ghana from June to August 2010. Sulfadoxine-pyrimethamine (SP) was used as intermittent preventative treatment (IPT) during pregnancy.
Excessive complement activation is of importance in the pathogenesis of placental malaria by mediating inflammation, coagulation, and endothelial dysfunction.
This study points to the effectiveness of IPTp using SP as an evidence-based measure for control of malaria and malaria-related anaemia in pregnancy.
The 371G allele of RNASE3 is associated with susceptibility to CM and forms part of a risk associated haplotype GGA defined by the markers: rs2073342 (G-allele), rs2233860 (G-allele) and rs8019343 (A-allele) respectively.
This study points to several strategies that may help bridge the gap between what is known from research evidence and the knowledge and practices of healthcare providers.
The results of this study suggest that net use would increase in Ghana if coloured nets were made available in mass distributions as well as in the commercial market;
The baseline malaria epidemiology suggests a high malaria transmission in the mining area prior to the start of mining activities.
The pfATPase6 gene is highly polymorphic with D639G appearing to be fixed in Ghanaian isolates.
All participants were positive for at least one malaria protein by ELISA, with results dependent on the criteria for positivity.
The data highlight the complexity of the situation prevailing in southern Ghana and the challenges facing the malaria vector control programmes in this region.