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Not Open Access | Analysis of Erythrocyte Invasion Mechanisms of Plasmodium falciparum Clinical Isolates Across 3 Malaria-Endemic Areas in Ghana

September 22, 2015 - 15:27 -- NOT Open Access
Author(s): 
Henrietta E. Mensah-Brown, Nicholas Amoako, James Abugri, Lindsay B. Stewart, Godfred Agongo, Emmanuel K. Dickson, Michael F. Ofori, José A. Stoute, David J. Conway and Gordon A. Awandare
Reference: 
J Infect Dis. (2015) 212 (8): 1288-1297.

We hypothesized that in malaria-endemic areas, parasites vary invasion pathways under immune pressure. Therefore, invasion mechanisms of clinical isolates collected from 3 zones of Ghana with different levels of endemicity (from lowest to highest, Accra, Navrongo, and Kintampo) were compared using standardized methods.

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Effect of insecticide-treated bed net usage on under-five mortality in northern Ghana

August 12, 2015 - 08:04 -- Open Access
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Author(s): 
Clifford Afoakwah, Jacob Nunoo, Francis Andoh
Reference: 
Malaria Journal 2015, 14:309 (7 August 2015)

The study, therefore, recommends that policies targeting reduction in under-five mortality in northern Ghana should consider not mere availability of ITNs in the household, but advocate the usage of these treated nets.

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Not Open Access | Assessing the economic benefits of vaccines based on the health investment life course framework: A review of a broader approach to evaluate malaria vaccination

July 31, 2015 - 17:12 -- NOT Open Access
Author(s): 
Dagna Constenla
Reference: 
Vaccine, Volume 33, Issue 13, 24 March 2015, Pages 1527-1540

We describe a framework that measures the impact of a health policy decision on government accounts over many generations. The methodological issues emerging from this approach are illustrated with an example from a recently completed health investment life course analysis of malaria vaccination in Ghana.

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Evaluation of the Diagnostic Accuracy of CareStart G6PD Deficiency Rapid Diagnostic Test (RDT) in a Malaria Endemic Area in Ghana, Africa

April 27, 2015 - 13:11 -- Open Access
Author(s): 
Dennis Adu-Gyasi, Kwaku Poku Asante, Seth Owusu-Agyei, et al.
Reference: 
PLoS ONE 10(4): e0125796

The outcome of this study suggests that the diagnostic performance of the CareStart G6PD deficiency RDT kit was high and it is acceptable at determining the G6PD deficiency status in a high malaria endemic area in Ghana.

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Polymorphisms in the Haem Oxygenase-1 promoter are not associated with severity of Plasmodium falciparum malaria in Ghanaian children

April 15, 2015 - 05:30 -- Open Access
Author(s): 
Hansson HH, Maretty L, Hempel C, et al.
Reference: 
Malaria Journal 2015, 14 :153 (11 April 2015)

These results contribute to the understanding of the role of HMOX1/HO-1.

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Outdoor-sleeping and other night-time activities in northern Ghana: implications for residual transmission and malaria prevention

February 25, 2015 - 15:06 -- Open Access
Author(s): 
April Monroe, Obed Asamoah, Yukyan Lam, Hannah Koenker, Paul Psychas, Matthew Lynch, Emily Ricotta, Sureyya Hornston, Amanda Berman, Steven A Harvey
Reference: 
Malaria Journal 2015, 14:33 (28 January 2015)

Study team members completed observations of 182 individuals across 24 households, 12 households per site. Between the two sites, they interviewed 14 health workers, six community health volunteers and 28 community residents.

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Measuring naturally acquired ex vivo IFN-γ responses to Plasmodium falciparum cell-traversal protein for ookinetes and sporozoites (CelTOS) in Ghanaian adults

February 3, 2015 - 16:10 -- Open Access
Author(s): 
Dorothy Anum, Kwadwo A Kusi, Martha Sedegah, et al.
Reference: 
Malaria Journal 2015, 14:20 (21 January 2015)

These results suggest natural malaria transmission induces CelTOS-specific ex vivo IFN-γ in Ghanaian adults and that the frequency of these responses was similar to those of other previously characterized malaria antigens.

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The outcome of a test-treat package versus routine outpatient care for Ghanaian children with fever: a pragmatic randomized control trial

December 10, 2014 - 16:28 -- Open Access
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Author(s): 
Emmanuel Ameyaw, Samuel B Nguah, Daniel Ansong, Iain Page, Martine Guillerm, Imelda Bates
Reference: 
Malaria Journal 2014, 13:461 (26 November 2014)

Test-treat package improves the effectiveness of outpatient diagnosis and treatment of children with fever and reduces inappropriate prescribing of anti-malarials and antibiotics.

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Geographically weighted regression of land cover determinants of Plasmodium falciparum transmission in the Ashanti Region of Ghana

October 10, 2014 - 17:44 -- Open Access
Author(s): 
Lutz Ehlkes, Anne Caroline Krefis, Jürgen May, et al.
Reference: 
International Journal of Health Geographics 2014, 13:35

We conclude that the spatially varying effects of LULC on P. falciparum parasitaemia may in fact be associated with co-factors not captured by remote sensing, and suggest that future studies assess small-scale spatial variation of vegetation to circumvent generalised assumptions on ecological associations that may in fact be artificial.

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Management of febrile children under five years in hospitals and health centres of rural Ghana

July 22, 2014 - 08:55 -- Open Access
Author(s): 
Webster J, Baiden F, Bawah J, Bruce J, Tivura M, Delmini R, Amenga-Etego S, Chandramohan D, Owusu-Agyei S
Reference: 
Malaria Journal 2014, 13 :261 (9 July 2014)

Interventions to improve adherence to negative parasitological tests are needed, together with guidance on dispensing of antibiotics, but improving the education of carers on how to administer ACT will lead to the greatest immediate increase in the effectiveness of case management.

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