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India

The burden of submicroscopic and asymptomatic malaria in India revealed from epidemiology studies at three varied transmission sites in India

December 2, 2019 - 17:58 -- Open Access
Author(s): 
van Eijk AM, Sutton PL, Alex Eapen, et al.
Reference: 
Sci Rep. 2019 Nov 19;9(1):17095

Malaria in India, while decreasing, remains a serious public health problem, and the contribution of submicroscopic and asymptomatic infections to its persistence is poorly understood. We conducted community surveys and clinic studies at three sites in India differing in their eco-epidemiologies: Chennai (Tamil Nadu), Nadiad (Gujarat), and Rourkela (Odisha), during 2012-2015. A total of 6,645 subject blood samples were collected for Plasmodium diagnosis by microscopy and PCR, and an extensive clinical questionnaire completed.  

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The burden of submicroscopic and asymptomatic malaria in India revealed from epidemiology studies at three varied transmission sites in India

November 19, 2019 - 14:53 -- Open Access
Author(s): 
Anna Maria van Eijk, Patrick L. Sutton, Alex Eapen, et al.
Reference: 
Scientific Reports volume 9, Article number: 17095 (2019)

Exploratory spatial analysis identified a number of potential malaria hotspots at all three sites. There is a considerable burden of submicroscopic and asymptomatic malaria in malarious regions in India, which may act as a reservoir with implications for malaria elimination strategies.

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Duffy antigen receptor for chemokines gene polymorphisms and malaria in Mangaluru, India

September 30, 2019 - 13:35 -- Open Access
Author(s): 
Prabhanjan P. Gai, Welmoed van Loon, Frank P. Mockenhaupt, et al.
Reference: 
Malaria Journal 2019 18:328, 24 September 2019

Duffy blood group antigens serve as receptors for Plasmodium vivax invasion into erythrocytes, and they are determined by polymorphisms of the Duffy antigen receptor for chemokines (DARC), also known as Fy glycoprotein (FY). Duffy negativity, i.e., absence of the antigens, protects against P. vivax infection and is rare among non-African populations. However, data on DARC polymorphisms and their impact on Plasmodium infection in India are scarce.

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Evaluation of MAGNet, a long-lasting insecticidal mosquito net against Anopheles fluviatilis in experimental huts in India

March 12, 2019 - 15:26 -- Open Access
Author(s): 
Gunasekaran Kasinathan, Sudhansu Sekhar Sahu, Vijayakumar Tharmalingam, Subramanian Swaminathan, Manju Rahi and Jambulingam Purushothaman
Reference: 
Malaria Journal 2019 18:59, 6 March 2019

MAGNet LN showed extended wash resistance retaining its bio-efficacy up to 25 washes and met the WHOPES requirement of passing Phase II evaluation.

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Reinvestigating the status of malaria parasite (Plasmodium sp.) in Indian non-human primates

December 12, 2018 - 16:13 -- Open Access
Author(s): 
Jyotsana Dixit, Arun Zachariah, Sajesh P. K., Bathrachalam Chandramohan, Vinoth Shanmuganatham, K. Praveen Karanth
Reference: 
PLoS Negl Trop Dis 12(12): e0006801

Many human parasites and pathogens have closely related counterparts among non-human primates.

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Characterization and monitoring of deltamethrin-resistance in Anopheles culicifacies in the presence of a long-lasting insecticide-treated net intervention

November 15, 2018 - 14:55 -- Open Access
Author(s): 
Madhavinadha Prasad Kona, Raghavendra Kamaraju, Veena Pandey, et al.
Reference: 
Malaria Journal 2018 17:414

This field study, in a tribal district of India, after distribution of deltamethrin-impregnated LLINs showed decrease in deltamethrin susceptibility in An. culicifacies, a major vector of malaria in this study area and in India. Results indicated development of resistance as imminent with the increase in insecticide selection pressure. 

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Malaria in Meghalaya: a systematic literature review and analysis of data from the National Vector-Borne Disease Control Programme

November 7, 2018 - 15:06 -- Open Access
Author(s): 
Anne Kessler, Anna Maria van Eijk, Limalemla Jamir, Catherine Walton, Jane M. Carlton and Sandra Albert
Reference: 
Malaria Journal 2018 17:411, 6 November 2018

Like malaria in mainland India, malaria in Meghalaya is complex, with both Plasmodium falciparum and Plasmodium vivax parasites in circulation, multiple Anopheles vector species, and reports of both unusual and severe malaria syndromes across all age groups.

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NOT Open Access | Bio-efficacy of LifeNet, a deltamethrin incorporated long-lasting insecticidal net, as assessed in experimental huts against Anopheles fluviatilis, a major malaria vector in east-central India

September 5, 2018 - 15:20 -- NOT Open Access
Author(s): 
Kasinathan Gunasekaran, Sudhansu Sekhar Sahu, Tharmalingam Vijayakumar, Swaminathan Subramanian, Purushothaman Jambulingam
Reference: 
Acta Tropica Volume 187, November 2018, Pages 151-157

LifeNet, a deltamethrin incorporated long-lasting insecticidal (polypropylene) net (LLIN), was qualified by the World Health Organization Pesticide Evaluation Scheme (WHOPES) for Phase-II trial in India.

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A pilot randomized controlled trial to compare the effectiveness of two 14-day primaquine regimens for the radical cure of vivax malaria in South India

September 4, 2018 - 16:07 -- Open Access
Author(s): 
Kavitha Saravu, Chaitanya Tellapragada, Krishnamurthy Bhat, et al.
Reference: 
Malaria Journal 2018 17:321, 3 September 2018

This small pilot trial supports the effectiveness of the currently recommended lower dose (0.25 mg/kg/day) 14 day PQ regimen for the radical cure of vivax malaria in South India.

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