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Tanzania

The impact on malaria of biannual treatment with azithromycin in children age less than 5 years: a prospective study

August 27, 2019 - 22:00 -- Open Access
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Author(s): 
Evan M. Bloch, Beatriz Munoz, Zakayo Mrango, Jerusha Weaver, Leonard E. G. Mboera, Tom M. Lietman, David J. Sullivan Jr. and Sheila K. West
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Malaria Journal 2019 18:284, 23 August 2019

The MORDOR study, a cluster randomized clinical trial, showed that single-dose azithromycin (20 mg/kg) administered biannually for 2 years to preschool children reduced mortality; a study was conducted to determine its effect on clinical symptomatic episodes of malaria as a potential mechanism for mortality benefit.

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Assessment of the impact of availability and readiness of malaria services on uptake of intermittent preventive treatment in pregnancy (IPTp) provided during ANC visits in Tanzania

July 12, 2019 - 16:27 -- Open Access
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Author(s): 
Shraddha Bajaria, Charles Festo, Sigilbert Mrema, Josephine Shabani, Ellen Hertzmark and Ramadhani Abdul
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Malaria Journal 2019 18:229, 9 July 2019

Intermittent preventive treatment during pregnancy (IPTp) is a highly-recommended intervention to prevent maternal and neonatal complications associated with malaria infection. Despite fairly high antenatal care (ANC) coverage in Tanzania, low IPTp uptake rates represent a gap in efforts to decrease complications attributed to malaria in pregnancy. The objective of this study was to examine if availability, readiness and managing authority are associated with uptake of IPTp during ANC.

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Spatio-temporal prevalence of malaria and anaemia in relation to agro-ecosystems in Mvomero district, Tanzania

July 12, 2019 - 16:25 -- Open Access
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Author(s): 
Susan F. Rumisha, Elizabeth H. Shayo and Leonard E. G. Mboera
Reference: 
Malaria Journal 2019 18:228, 9 July 2019

Agro-ecological systems have been associated with increased malaria intensity. This study determined association between different agro-ecological systems, prevalence of malaria parasitaemia and anaemia in Mvomero district, Tanzania.

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Malaria mosquito control in rice paddy farms using biolarvicide mixed with fertilizer in Tanzania: semi-field experiments

July 8, 2019 - 17:07 -- Open Access
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Author(s): 
Humphrey D. Mazigo, Leonard E. G. Mboera, Susan F. Rumisha and Eliningaya J. Kweka
Reference: 
Malaria Journal 2019 18:226, 8 July 2019

The wide distribution of malaria mosquito breeding sites within tropical environments limits the mosquito larval source management efforts to control malaria. Rice farming contributes substantially in supporting malaria mosquito productivity in tropical countries. To overcome this challenge, this study was carried out to determine the effect of applying a mixture of biolarvicide and fertilizer on mosquito larvae density in rice farms under semi-field conditions in Tanzania.

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Linking human behaviours and malaria vector biting risk in south-eastern Tanzania

June 11, 2019 - 15:07 -- Open Access
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Author(s): 
Marceline F. Finda, Irene R. Moshi, Fredros O. Okumu, et al.
Reference: 
PLoS ONE 14(6): e0217414

To accelerate malaria elimination in areas where core interventions such as insecticide-treated nets (ITNs) are already widely used, it is crucial to consider additional factors associated with persistent transmission.

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Autodissemination of pyriproxyfen suppresses stable populations of Anopheles arabiensis under semi-controlled settings

May 13, 2019 - 14:37 -- Open Access
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Author(s): 
Dickson Lwetoijera, Samson Kiware, Fredros Okumu, Gregor J. Devine and Silas Majambere
Reference: 
Malaria Journal 2019 18:166, 9 May 2019

Autodissemination of pyriproxyfen (PPF), i.e. co-opting adult female mosquitoes to transfer the insect growth regulator, pyriproxyfen (PPF) to their aquatic habitats has been demonstrated for Aedes and Anopheles mosquitoes. This approach, could potentially enable high coverage of aquatic mosquito habitats, including those hard to locate or reach via conventional larviciding. This study demonstrated impacts of autodissemination in crashing a stable and self-sustaining population of the malaria vector, Anopheles arabiensis under semi-field conditions in Tanzania.

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NOT Open Access | A population‐based study of the prevalence and risk factors of low‐grade Plasmodium falciparum malaria infection in children aged 0–15 years old in northern Tanzania

May 7, 2019 - 14:59 -- NOT Open Access
Author(s): 
S. Peprah, H. Dhudha, S. M. Mbulaiteye, et al.
Reference: 
Tropical Medicine & International Health Volume24, Issue5 May 2019 Pages 571-585

Northern Tanzania experiences significant malaria‐related morbidity and mortality, but accurate data are scarce. We update the data on patterns of low‐grade Plasmodium falciparum malaria infection among children in northern Tanzania.

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Two cases of long-lasting, sub-microscopic Plasmodium malariae infections in adults from coastal Tanzania

May 3, 2019 - 17:18 -- Open Access
Author(s): 
Tobias Schindler, Said Jongo, Claudia Daubenberger, et al.
Reference: 
Malaria Journal 2019 18:149, 29 April 2019

Background

Malaria is endemic in Tanzania with majority of clinical cases caused by Plasmodium falciparum. Additionally, Plasmodium malariae and Plasmodium ovale spp. are also present and clinical manifestations caused by these infections are not well described. Clinical episodes caused by P. malariae infections are often characterized by a relatively mild illness with a low number of parasites, which can persist for long periods. In this report, two cases of P. malariae infections that were identified during a clinical trial evaluating the P. falciparum malaria vaccine candidate, PfSPZ Vaccine are described. The two participants were followed up and monitored for clinical and laboratory parameters to assess vaccine safety providing the opportunity to study clinical manifestations of P. malariae over 4 months.

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Insecticides, bednets and medicines may slow malaria down, but real progress requires a more holistic approach

April 25, 2019 - 10:06 -- Fredros Okumu
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IN 30 SECONDS: There is no doubt that bed nets, insecticides, medicines and diagnostics will deliver significant successes against malaria in the short-term. But as major international partners continue prioritizing the commodity-based approach, African governments should be building the necessary resilience in affected communities. Countries should ensure safe houses and physical environments so that exposure to mosquito bites is minimized, strengthen health systems to identify and treat new malaria cases, expand access to health education in schools and households, and improve household economies and food security so that competing priorities are addressed. This needs to be a long-term strategy, paid for by domestic funding, subsidies, tax rebates or other innovative financing mechanisms – for example a ten-dollar malaria levy paid by international travelers visiting endemic countries. This way, the affected countries can better avoid malaria deaths and sickness, or rebounds of transmission, which currently place such a strain on national health outcomes and development.

Comparison of malaria treatment outcome of generic and innovator’s anti-malarial drugs containing artemether–lumefantrine combination in the management of uncomplicated malaria amongst Tanzanian children

April 14, 2019 - 17:09 -- Open Access
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Author(s): 
Manase Kilonzi, Omary Minzi, Ritah Mutagonda, Philip Sasi, Appolinary Kamuhabwa and Eleni Aklillu
Reference: 
Malaria Journal 2019 18:133, 11 April 2019

 

The findings of this study indicate that both Artefan® and Coartem® are equivalent and effective in the management of uncomplicated malaria amongst children in the Coast part of Tanzania.

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