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Tanzania

Autodissemination of pyriproxyfen suppresses stable populations of Anopheles arabiensis under semi-controlled settings

May 13, 2019 - 14:37 -- Open Access
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Author(s): 
Dickson Lwetoijera, Samson Kiware, Fredros Okumu, Gregor J. Devine and Silas Majambere
Reference: 
Malaria Journal 2019 18:166, 9 May 2019

Autodissemination of pyriproxyfen (PPF), i.e. co-opting adult female mosquitoes to transfer the insect growth regulator, pyriproxyfen (PPF) to their aquatic habitats has been demonstrated for Aedes and Anopheles mosquitoes. This approach, could potentially enable high coverage of aquatic mosquito habitats, including those hard to locate or reach via conventional larviciding. This study demonstrated impacts of autodissemination in crashing a stable and self-sustaining population of the malaria vector, Anopheles arabiensis under semi-field conditions in Tanzania.

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NOT Open Access | A population‐based study of the prevalence and risk factors of low‐grade Plasmodium falciparum malaria infection in children aged 0–15 years old in northern Tanzania

May 7, 2019 - 14:59 -- NOT Open Access
Author(s): 
S. Peprah, H. Dhudha, S. M. Mbulaiteye, et al.
Reference: 
Tropical Medicine & International Health Volume24, Issue5 May 2019 Pages 571-585

Northern Tanzania experiences significant malaria‐related morbidity and mortality, but accurate data are scarce. We update the data on patterns of low‐grade Plasmodium falciparum malaria infection among children in northern Tanzania.

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Two cases of long-lasting, sub-microscopic Plasmodium malariae infections in adults from coastal Tanzania

May 3, 2019 - 17:18 -- Open Access
Author(s): 
Tobias Schindler, Said Jongo, Claudia Daubenberger, et al.
Reference: 
Malaria Journal 2019 18:149, 29 April 2019

Background

Malaria is endemic in Tanzania with majority of clinical cases caused by Plasmodium falciparum. Additionally, Plasmodium malariae and Plasmodium ovale spp. are also present and clinical manifestations caused by these infections are not well described. Clinical episodes caused by P. malariae infections are often characterized by a relatively mild illness with a low number of parasites, which can persist for long periods. In this report, two cases of P. malariae infections that were identified during a clinical trial evaluating the P. falciparum malaria vaccine candidate, PfSPZ Vaccine are described. The two participants were followed up and monitored for clinical and laboratory parameters to assess vaccine safety providing the opportunity to study clinical manifestations of P. malariae over 4 months.

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Insecticides, bednets and medicines may slow malaria down, but real progress requires a more holistic approach

April 25, 2019 - 10:06 -- Fredros Okumu
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There is no doubt that bed nets, insecticides, medicines and diagnostics will deliver significant successes against malaria in the short-term. But as major international partners continue prioritizing the commodity-based approach, African governments should be building the necessary resilience in affected communities. Countries should ensure safe houses and physical environments so that exposure to mosquito bites is minimized, strengthen health systems to identify and treat new malaria cases, expand access to health education in schools and households, and improve household economies and food security so that competing priorities are addressed. This needs to be a long-term strategy, paid for by domestic funding, subsidies, tax rebates or other innovative financing mechanisms – for example a ten-dollar malaria levy paid by international travelers visiting endemic countries. This way, the affected countries can better avoid malaria deaths and sickness, or rebounds of transmission, which currently place such a strain on national health outcomes and development.

Comparison of malaria treatment outcome of generic and innovator’s anti-malarial drugs containing artemether–lumefantrine combination in the management of uncomplicated malaria amongst Tanzanian children

April 14, 2019 - 17:09 -- Open Access
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Author(s): 
Manase Kilonzi, Omary Minzi, Ritah Mutagonda, Philip Sasi, Appolinary Kamuhabwa and Eleni Aklillu
Reference: 
Malaria Journal 2019 18:133, 11 April 2019

 

The findings of this study indicate that both Artefan® and Coartem® are equivalent and effective in the management of uncomplicated malaria amongst children in the Coast part of Tanzania.

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In vitro and in vivo studies on anti-malarial activity of Commiphora africana and Dichrostachys cinerea used by the Maasai in Arusha region, Tanzania

April 8, 2019 - 16:15 -- Open Access
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Author(s): 
Prisca A. Kweyamba, Denis Zofou, Noella Efange, Jules-Clement N. Assob, Jovin Kitau and Mramba Nyindo
Reference: 
Malaria Journal 2019 18:119, 4 April 2019

The findings of this study provide scientific evidence supporting the traditional use of the plants in the treatment of malaria by the Maasai in Arusha region, Tanzania.

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Dynamics and monitoring of insecticide resistance in malaria vectors across mainland Tanzania from 1997 to 2017: a systematic review

March 27, 2019 - 16:04 -- Open Access
Author(s): 
Deokary Joseph Matiya, Anitha B. Philbert, Winifrida Kidima and Johnson J. Matowo
Reference: 
Malaria Journal 2019 18:102, 26 March 2019

This review has shown the dynamics and monitoring of insecticide resistance in malaria vector populations across mainland Tanzanian.

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High cure rates and tolerability of artesunate–amodiaquine and dihydroartemisinin–piperaquine for the treatment of uncomplicated falciparum malaria in Kibaha and Kigoma, Tanzania

March 27, 2019 - 15:59 -- Open Access
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Author(s): 
Celine I. Mandara, Filbert Francis, Deus S. Ishengoma, et al.
Reference: 
Malaria Journal 2019 18:99, 25 March 2019

Both artemisinin-based combinations had high cure rates with PCR corrected ACPR of 100%.

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Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated malaria and prevalence of Pfk13 and Pfmdr1 polymorphisms after a decade of using artemisinin-based combination therapy in mainland Tanzania

March 26, 2019 - 15:45 -- Open Access
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Author(s): 
Deus S. Ishengoma, Celine I. Mandara, Venkatachalam Udhayakumar, et al.
Reference: 
Malaria Journal 2019 18:88, 21 March 2019

The study indicated high efficacy of AL and the safety profile was consistent with previous reports.

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‘The mosquitoes are preparing to attack us’: knowledge and perceptions of communities in south-eastern Tanzania regarding mosquito swarms

February 28, 2019 - 15:46 -- Open Access
Author(s): 
Marceline F. Finda, Emmanuel W. Kaindoa, Anna P. Nyoni and Fredros O. Okumu
Reference: 
Malaria Journal 2019 18:56, 26 February 2019

Majority of the community members recognized presence of mosquito swarms in their communities but did not associate these swarms with mosquito mating.

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