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Kenya

No Evidence of Plasmodium falciparum k13 Artemisinin Resistance-Conferring Mutations over a 24-Year Analysis in Coastal Kenya but a Near Complete Reversion to Chloroquine-Sensitive Parasites

December 3, 2019 - 15:39 -- Open Access
Author(s): 
Kevin Wamae, Dorcas Okanda, Leonard Ndwiga, Victor Osoti, Kelvin M. Kimenyi, Abdirahman I. Abdi, Philip Bejon, Colin Sutherland and Lynette Isabella Ochola-Oyier
Reference: 
AntimicrobialAgents and Chemotherap December 2019 Volume 63 Issue 12 e01067-19

Antimalarial drug resistance is a substantial impediment to malaria control. The spread of resistance has been described using genetic markers, which are important epidemiological tools. We carried out a temporal analysis of changes in allele frequencies of 12 drug resistance markers over 2 decades of changing antimalarial drug policy in Kenya. We did not detect any of the validated kelch 13 (k13) artemisinin resistance markers; nonetheless, a single k13 allele, K189T, was maintained at a stable high frequency (>10%) over time.

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Integrated Cross-Sectional Multiplex Serosurveillance of IgG Antibody Responses to Parasitic Diseases and Vaccines in Coastal Kenya

November 27, 2019 - 16:14 -- Open Access
Author(s): 
Njenga SM, Kanyi HM, Arnold BF, Matendechero SH, Onsongo JK, Won KY, Priest JW.
Reference: 
Am. J. Trop. Med. Hyg., 00(0), 2019, pp. 1–13

Accurate and cost-effective identification of areas where co-endemic infections occur would enable public health managers to identify opportunities for implementation of integrated control programs. Dried blood spots collected during cross-sectional lymphatic filariasis surveys in coastal Kenya were used for exploratory integrated detection of IgG antibodies against antigens from several parasitic infections (Wuchereria bancrofti, Schistosoma mansoni, Plasmodium spp., Ascaris lumbricoides, and Strongyloides stercoralis) as well as for detection of responses to immunizing agents used against vaccine-preventable diseases (VPDs) (measles, diphtheria, and tetanus) using a multiplex bead assay (MBA) platform.

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NOT Open Access | Prevalence of mutations in Plasmodium falciparum genes associated with resistance to different antimalarial drugs in Nyando, Kisumu County in Kenya

November 26, 2019 - 13:55 -- NOT Open Access
Author(s): 
Musyoka KB, Kiiru JN, Aluvaala E, Omondi P, Chege WK, Judah T, Kiboi D, Nganga JK, Kimani FT.
Reference: 
Infection, Genetics and Evolution, 19 November 2019, 104121

Resistance to the mainstay antimalarial drugs is a major concern in the control of malaria. Delayed Plasmodium falciparum parasite clearance has been associated with Single Nucleotide Polymorphisms (SNPs) in the kelch propeller region (K13). However, SNPs in the Pf-adaptor protein complex 2 mu subunit (Pfap2-mu), Pfcrt and Pfmdr1 are possible markers associated with multi-drug resistance. Here, we explored the prevalence of SNPs in the K13, Pfap2-mu, Pfcrt, and Pfmdr1 in 94 dried blood spot field isolates collected from children aged below 12 years infected with P. falciparum during a cross-sectional study.

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Not Open Access | Cyclooxygenase-2 haplotypes influence the longitudinal risk of malaria and severe malarial anemia in Kenyan children from a holoendemic transmission region

November 19, 2019 - 15:08 -- NOT Open Access
Author(s): 
Samuel B. Anyona, Nicolas W. Hengartner, Douglas J. Perkins, et al.
Reference: 
Journal of Human Genetics (2019)

The investigation was carried out in children (n = 1081, age; 2–70 months) residing in a holoendemic Plasmodium falciparum transmission region of western Kenya. At enrollment, genotypes/haplotypes (controlling for anemia-promoting covariates) did not reveal any strong effects on susceptibility to either malaria or SMA. 

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Controlled Human Malaria Infection in Semi-Immune Kenyan Adults (CHMI-SIKA): a study protocol to investigate in vivo Plasmodium falciparum malaria parasite growth in the context of pre-existing immunity

November 19, 2019 - 14:50 -- Open Access
Author(s): 
Melissa C. Kapulu , Patricia Njuguna, Mainga M. Hamaluba
Reference: 
Wellcome Open Research 2019, 3:155

We aim to recruit up to 200 healthy adult volunteers from areas of differing malaria transmission in Kenya, and after confirming their health status through clinical examination and routine haematology and biochemistry, we will comprehensively characterize immunity to malaria using >100 blood-stage antigens. 

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HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya

September 10, 2019 - 15:15 -- Open Access
Author(s): 
Eliud O. Odhiambo, Dibyadyuti Datta, Bernard Guyah, George Ayodo, Bartholomew N. Ondigo, Benard O. Abong’o, Chandy C. John and Anne E. P. Frosch
Reference: 
Malaria Journal 2019 18:297, 30 August 2019

HIV infection is associated with more frequent and severe episodes of malaria and may be the result of altered malaria-specific B cell responses. However, it is poorly understood how HIV and the associated lymphopenia and immune activation affect malaria-specific antibody responses.

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Using sibship reconstructions to understand the relationship between larval habitat productivity and oviposition behaviour in Kenyan Anopheles arabiensis

August 27, 2019 - 22:06 -- Open Access
Author(s): 
Joel O. Odero, Ulrike Fillinger, Emily J. Rippon, Daniel K. Masiga and David Weetman
Reference: 
Malaria Journal 2019 18:286, 23 August 2019

Strategies for combatting residual malaria by targeting vectors outdoors are gaining importance as the limitations of primary indoor interventions are reached. Strategies to target ovipositing females or her offspring are broadly applicable because all mosquitoes require aquatic habitats for immature development irrespective of their biting or resting preferences. Oviposition site selection by gravid females is frequently studied by counting early instar larvae in habitats; an approach which is valid only if the number of larvae correlates with the number of females laying eggs. This hypothesis was tested against the alternative, that a higher abundance of larvae results from improved survival of a similar or fewer number of families.

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Bed net care practices and associated factors in western Kenya

August 19, 2019 - 17:33 -- Open Access
Author(s): 
Ellen M. Santos, Jenna E. Coalson, Elizabeth T. Jacobs, Yann C. Klimentidis, Stephen Munga, Maurice Agawo, Elizabeth Anderson, Nancy Stroupe and Kacey C. Ernst
Reference: 
Malaria Journal 2019 18:274, 14 August 2019

Insecticide-treated nets (ITNs) and long-lasting insecticidal nets (LLINs) are effective for malaria prevention and are designed to provide nearly 5 years of mosquito protection. However, many ITNs and LLINs become damaged and ineffective for mosquito bite prevention within 1 to 2 years in field conditions. Non-adherence to recommended bed net care and repair practices may partially explain this shortened net longevity.

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Community-based intermittent mass testing and treatment for malaria in an area of high transmission intensity, western Kenya: development of study site infrastructure and lessons learned

July 30, 2019 - 08:25 -- Open Access
Tags: 
Author(s): 
Norbert Awino Odero, Aaron M. Samuels, Meghna Desai, et al.
Reference: 
Malaria Journal 2019 18:255, 29 July 2019

Malaria transmission is high in western Kenya and the asymptomatic infected population plays a significant role in driving the transmission. Mathematical modelling and simulation programs suggest that interventions targeting asymptomatic infections through mass testing and treatment (MTaT) or mass drug administration (MDA) have the potential to reduce malaria transmission when combined with existing interventions.

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Diagnostic dose determination and efficacy of chlorfenapyr and clothianidin insecticides against Anopheles malaria vector populations of western Kenya

July 21, 2019 - 21:46 -- Open Access
Author(s): 
Silas Agumba, John E. Gimnig, Lilian Ogonda, Maurice Ombok, Jackline Kosgei, Stephen Munga, Benard Guyah, Seline Omondi and Eric Ochomo
Reference: 
Malaria Journal 2019 18:243, 17 July 2019

Malaria vector control is dependent on chemical insecticides applied to walls by indoor residual spraying or on long-lasting insecticidal nets. The emergence and spread of insecticide resistance in major malaria vectors may compromise malaria control and elimination efforts. The aim of this study was to estimate a diagnostic dose for chlorfenapyr (class: pyrrole) and clothianidin (class: neonicotinoid) and assess the baseline susceptibility of three major Anopheles malaria vectors of western Kenya to these two insecticides.

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