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Kenya

Community-based intermittent mass testing and treatment for malaria in an area of high transmission intensity, western Kenya: development of study site infrastructure and lessons learned

July 30, 2019 - 08:25 -- Open Access
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Author(s): 
Norbert Awino Odero, Aaron M. Samuels, Meghna Desai, et al.
Reference: 
Malaria Journal 2019 18:255, 29 July 2019

Malaria transmission is high in western Kenya and the asymptomatic infected population plays a significant role in driving the transmission. Mathematical modelling and simulation programs suggest that interventions targeting asymptomatic infections through mass testing and treatment (MTaT) or mass drug administration (MDA) have the potential to reduce malaria transmission when combined with existing interventions.

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Diagnostic dose determination and efficacy of chlorfenapyr and clothianidin insecticides against Anopheles malaria vector populations of western Kenya

July 21, 2019 - 21:46 -- Open Access
Author(s): 
Silas Agumba, John E. Gimnig, Lilian Ogonda, Maurice Ombok, Jackline Kosgei, Stephen Munga, Benard Guyah, Seline Omondi and Eric Ochomo
Reference: 
Malaria Journal 2019 18:243, 17 July 2019

Malaria vector control is dependent on chemical insecticides applied to walls by indoor residual spraying or on long-lasting insecticidal nets. The emergence and spread of insecticide resistance in major malaria vectors may compromise malaria control and elimination efforts. The aim of this study was to estimate a diagnostic dose for chlorfenapyr (class: pyrrole) and clothianidin (class: neonicotinoid) and assess the baseline susceptibility of three major Anopheles malaria vectors of western Kenya to these two insecticides.

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Epidemiological risk factors for clinical malaria infection in the highlands of Western Kenya

July 1, 2019 - 15:31 -- Open Access
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Author(s): 
Walters M. Essendi, Anne M. Vardo-Zalik, Eugenia Lo, Maxwell G. Machani, Guofa Zhou, Andrew K. Githeko, Guiyun Yan and Yaw A. Afrane
Reference: 
Malaria Journal 2019 18:211, 24 June 2019

Understanding the complex heterogeneity of risk factors that can contribute to an increased risk of malaria at the individual and household level will enable more effective use of control measures. The objective of this study was to understand individual and household factors that influence clinical malaria infection among individuals in the highlands of Western Kenya.

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Influence of blood meal and age of mosquitoes on susceptibility to pyrethroids in Anopheles gambiae from Western Kenya

April 4, 2019 - 15:53 -- Open Access
Author(s): 
Maxwell G. Machani, Eric Ochomo, David Sang, Mariangela Bonizzoni, Guofa Zhou, Andrew K. Githeko, Guiyun Yan and Yaw A. Afrane
Reference: 
Malaria Journal 2019 18:112, 2 April 2019

The results showed that mosquito age and blood feeding status confers increased tolerance to insecticides as blood feeding may be playing an important role in the toxicity of deltamethrin, allowing mosquitoes to rest on insecticide-treated materials despite treatment.

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NOT Open Access | Antimalarial bednet protection of children disappears when shared by three or more people in a high transmission setting of western Kenya

March 6, 2019 - 13:28 -- NOT Open Access
Author(s): 
Brenda Solórzano García, Amanda D. Melin, Filippo Aureli, Gerardo Pérez Ponce de León
Reference: 
Parasitology, Volume 146 / Issue 3, March 2019, pp 356 - 362

A sizeable proportion of households is forced to share single long-lasting insecticide treated net (LLIN).

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NOT Open Access | Mapping potential Anopheles gambiae s.l. larval distribution using remotely sensed climatic and environmental variables in Baringo, Kenya

November 7, 2018 - 14:46 -- NOT Open Access
Author(s): 
J. A. Amadi, G. O. Ong'amo, D. O. Olago, S. O. Oriaso, I. K. Nyamongo, B. B. A. Estambale
Reference: 
Medical and Veterinary Entomology Volume32, Issue4 December 2018 Pages 417-426

Anopheles gambiae s.l. (Diptera: Culicidae) is responsible for the transmission of the devastating Plasmodium falciparum (Haemosporida: Plasmodiidae) strain of malaria in Africa.

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Selective sweeps and genetic lineages of Plasmodium falciparum multi-drug resistance (pfmdr1) gene in Kenya

October 31, 2018 - 15:36 -- Open Access
Author(s): 
Peninah Muiruri, Denis W. Juma, Edwin Kamau, et al.
Reference: 
Malaria Journal 2018 17:398, 30 October 2018

Selection pressures were observed to be different in different regions of Kenya, especially the western region compared to the coastal region.

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Spatio-temporal analysis of Plasmodium falciparum prevalence to understand the past and chart the future of malaria control in Kenya

October 2, 2018 - 15:27 -- Open Access
Author(s): 
Peter M. Macharia, Emanuele Giorgi, Abdisalan M. Noor, Ejersa Waqo, Rebecca Kiptui, Emelda A. Okiro and Robert W. Snow
Reference: 
Malaria Journal 2018 17:340, 26 September 2018

Kenya has made substantial progress in reducing the prevalence of malaria over the last 26 years.

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The quality of anti-malarial medicines in Embu County, Kenya

September 18, 2018 - 16:11 -- Open Access
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Author(s): 
Stanley Ndwigah, Andy Stergachis, Kennedy Abuga, Hannington Mugo and Isaac Kibwage
Reference: 
Malaria Journal 2018 17:330, 15 September 2018

All the anti-malarial drugs analysed in this study passed the quality control tests.

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Volatile biomarkers of symptomatic and asymptomatic malaria infection in humans

May 31, 2018 - 15:26 -- Open Access
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Author(s): 
Consuelo M. De Moraes, Caroline Wanjiku, Mark C. Mescher, et al.
Reference: 
PNAS May 29, 2018. 115 (22) 5780-5785

Malaria remains among the world’s deadliest diseases, and control efforts depend critically on the availability of effective diagnostic tools, particularly for the identification of asymptomatic infections, which play a key role in disease persistence and may account for most instances of transmission but often evade detection by current screening methods.

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