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The Democratic Republic of the Congo (DRC)

Plasmodium falciparum genetic variation of var2csa in the Democratic Republic of the Congo

January 24, 2018 - 13:28 -- Open Access
Robert Verity, Nicholas J. Hathaway, Steven R. Meshnick, et al.
Malaria Journal 2018 17:46, 24 January 2018

Results suggest that the DRC fits within the global pattern of high var2csa diversity and little genetic differentiation between regions.

Individual and household characteristics of persons with Plasmodium falciparum malaria in sites with varying endemicities in Kinshasa Province, Democratic Republic of the Congo

November 14, 2017 - 15:50 -- Open Access
Melchior Kashamuka Mwandagalirwa, Lauren Levitz, Margaret Carrel, et al.
Malaria Journal 2017 16:456, 9 November 2017

The study cohort will provide an understanding of how malaria persists in populations that have varying environmental exposures, varying community-level malaria, and varying access to malaria control efforts.

Malaria vectors in the Democratic Republic of the Congo: the mechanisms that confer insecticide resistance in Anopheles gambiae and Anopheles funestus

November 13, 2017 - 15:26 -- Open Access
Luisa Nardini, Richard H. Hunt, Yael L. Dahan-Moss, Nanette Christie, Riann N. Christian, Maureen Coetzee and Lizette L. Koekemoer
Malaria Journal 2017 16:448, 7 November 2017

These data show that high levels of deltamethrin resistance in the main malaria vector species, conferred by enzymatic detoxification, are present in the DRC.

Feasibility and acceptability of injectable artesunate for the treatment of severe malaria in the Democratic Republic of Congo

January 12, 2016 - 17:20 -- Open Access
Henry Ntuku, Gianfrancesco Ferrari, Christian Burri, Antoinette Tshefu, Didier Kalemwa, Christian Lengeler
Malaria Journal 2016, 15:18 (8 January 2016)

These findings show that the use of injectable artesunate for the treatment of severe malaria is feasible and acceptable in the context of DRC, with appropriate training of care providers.

An operational comparative study of quinine and artesunate for the treatment of severe malaria in hospitals and health centres in the Democratic Republic of Congo: the MATIAS study

June 2, 2015 - 08:42 -- Open Access
Giovanfrancesco Ferrari, Henry Ntuku, Christian Lengeler, et al.
Malaria Journal 2015, 14:226 (30 May 2015)

This study demonstrates that injectable artesunate in the DRC is easier to use and it costs less than injectable quinine.

Medical Treatment: 

Randomized Comparison of the Efficacies and Tolerabilities of Three Artemisinin-Based Combination Treatments for Children with Acute Plasmodium falciparum Malaria in the Democratic Republic of the Congo

August 19, 2014 - 14:12 -- Open Access
M. A. Onyamboko, C. I. Fanello, K. Wongsaen, J. Tarning, P. Y. Cheah, K. A. Tshefu, A. M. Dondorp, F. Nosten, N. J. White, and N. P. J. Day
Antimicrob. Agents Chemother. September 2014 vol. 58 no. 9 5528-5536

An open-label, randomized controlled trial was carried out in 2011–2012 in the Democratic Republic of the Congo to test the efficacy, safety, and tolerability of the artemisinin-based combination treatments dihydroartemisinin-piperaquine, amodiaquine-artesunate, and artemether-lumefantrine.

Performance of HRP2-based rapid test in children attending the health centre compared to asymptomatic children in the community

August 19, 2014 - 14:02 -- Open Access
Ilombe G, Maketa V, Mavoko HM, da Luz RI, Lutumba P, Van geertruyden J
Malaria Journal 2014, 13 :308 (9 August 2014)

HRP-based RDT gives a satisfactory proxy to estimate and monitor malaria endemicity, but the low specificity, far below the selection criteria of the NMCP, DRC is problematic for use in a clinical setting.

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